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Autocat SIGNED

Autocatalysis: A bottom-up approach to understanding the origins of life

Total Cost €

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EC-Contrib. €

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Partnership

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Project "Autocat" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙278˙073 €
 EC max contribution 2˙278˙073 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙278˙073.00

Map

 Project objective

'The origin of life is not well understood, and is one of the great remaining questions in science. Autocatalytic chemical reactions have been extensively studied with the aim of providing insight into the principles underlying living systems. In biology, organisms can be thought of as imperfect self-replicators, which produce closely related species, allowing for selection and evolution. Autocatalysis is also an important part of many other biological processes. This project aims to develop new autocatalytic reactions where two simple chemical building blocks come together to give a more complex product, and then the product aggregates to give primitive cell-like structures or 'protocells' such as micelles or vesicles. The protocells allow the starting materials to mix more efficiently, speeding up the reaction in time and giving rise to complex behaviour of the protocells. These reactions will serve as models that I hope will contribute to understanding how cell-like systems can emerge from simpler chemicals and be relevant to how life started on earth. This project will give the opportunity to study chemical systems that may be able to evolve in time, allow development of useful chemical models of important biological processes, and provide ‘bottom-up’ approaches to synthetic biology. This research will potential allow the study evolution in a new ways, develop technology useful to a number of scientific fields, and potentially shed light on the processes that allowed chemistry to become biology on the primitive Earth.'

 Publications

year authors and title journal last update
List of publications.
2018 Ignacio Colomer, Sarah M. Morrow, Stephen P. Fletcher
A transient self-assembling self-replicator
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04670-2
Nature Communications 9/1 2019-04-18
2016 Jaime Ortega-Arroyo, Andrew J. Bissette, Philipp Kukura, Stephen P. Fletcher
Visualization of the spontaneous emergence of a complex, dynamic, and autocatalytic system
published pages: 11122-11126, ISSN: 0027-8424, DOI: 10.1073/pnas.1602363113
Proceedings of the National Academy of Sciences 113/40 2019-04-18
2017 Sarah M. Morrow, Andrew J. Bissette, Stephen P. Fletcher
Potential for minimal self-replicating systems in a dynamic combinatorial library of equilibrating imines
published pages: 5005-5010, ISSN: 0040-4020, DOI: 10.1016/j.tet.2017.06.045
Tetrahedron 73/33 2019-04-18
2018 Elias A. J. Post, Andrew J. Bissette, Stephen P. Fletcher
Self-reproducing micelles coupled to a secondary catalyst
published pages: 8777-8780, ISSN: 1359-7345, DOI: 10.1039/c8cc02136h
Chemical Communications 54/63 2019-04-18
2019 Sarah M. Morrow, Ignacio Colomer, Stephen P. Fletcher
A chemically fuelled self-replicator
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-08885-9
Nature Communications 10/1 2019-04-18
2019 Elias A. J. Post, Stephen P. Fletcher
Controlling the Kinetics of Self-Reproducing Micelles by Catalyst Compartmentalization in a Biphasic System
published pages: 2741-2755, ISSN: 0022-3263, DOI: 10.1021/acs.joc.8b03149
The Journal of Organic Chemistry 84/5 2019-04-18

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