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EVO-MEIO SIGNED

Adaptive evolution of meiosis in response to genome and habitat change

Total Cost €

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EC-Contrib. €

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Partnership

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 EVO-MEIO project word cloud

Explore the words cloud of the EVO-MEIO project. It provides you a very rough idea of what is the project "EVO-MEIO" about.

copies    discover    melds    meiotic    multiprotein    proteins    evolutionary    happens    genome    rational    polyploid    time    arenosa    critical    instability    genomic    primary    fertile    previously    sweeps    functions    stability    rates    selective    orchestrate    polyploids    cellular    stable    reflects    eukaryotes    architecture    genetic    environmental    constrained    upset    crossover    duplication    model    core    evolution    fertility    adaptive    showing    structures    biochemically    structural    divergence    lineages    multidisciplinary    insights    organisms    multivalent    autopolyploid    keeping    evolve    eight    homolog    stabilization    pattern    retune    prevent    nevertheless    rely    environment    sequence    stresses    occurred    house    overcome    co    reducing    functionally    undergone    improvement    kingdoms    survival    eukaryotic    becomes    suited    wgd    taxa    doubles    rate    showed    sexual    exist    hypothesize    acted    potent    arabidopsis    cytological    repeatedly    chromosome    molecular    meiosis    transient    conserved    meiotically    module    associations    crop   

Project "EVO-MEIO" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website http://bomblies.jic.ac.uk
 Total cost 1˙972˙386 €
 EC max contribution 1˙972˙386 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 750˙793.00
2    JOHN INNES CENTRE UK (NORWICH) participant 1˙221˙592.00

Map

 Project objective

Organisms rely on conserved cellular “house-keeping” processes for survival and fertility, but many of these can be upset by common environmental or cellular stresses. What happens if such a challenge becomes more than transient? Meiosis is a well-suited model for understanding how a constrained multiprotein process can evolve; it is biochemically well characterized, critical for fertility in sexual eukaryotes, and its core structures and functions are conserved across kingdoms. Yet proteins that orchestrate meiosis often have high primary sequence divergence among taxa and in some cases have undergone selective sweeps. We hypothesize this pattern reflects a need to repeatedly retune meiotic structures to new conditions over evolutionary time. Environment and genome architecture can both affect meiosis, but a common and particularly potent challenge is whole genome duplication (WGD), which has occurred in most major eukaryotic lineages. But WGD doubles the number of copies of each homolog present, and this can lead to formation of multivalent chromosome associations in meiosis, which can cause meiotic instability and low fertility. Nevertheless, many fertile and meiotically stable polyploids exist, showing that evolution can overcome this challenge. Here we will study how meiotic stability evolved in autopolyploid Arabidopsis arenosa. We previously showed selection acted on eight structural meiosis proteins and hypothesize these co-evolved as an “adaptive module” to prevent multivalent formation by reducing genome-wide crossover rates. This multidisciplinary research programme melds cytological, molecular, genetic, and genomic approaches to discover how meiosis functionally evolved before and after WGD. This work will provide novel insights into how a functionally constrained multiprotein process can evolve in response to challenges, and by providing understanding of crossover rate evolution and polyploid stabilization, is also relevant to rational crop improvement.

 Publications

year authors and title journal last update
List of publications.
2017 Christopher H. Morgan, Huakun Zhang, Kirsten Bomblies
Are the effects of elevated temperature on meiotic recombination and thermotolerance linked via the axis and synaptonemal complex?
published pages: 20160470, ISSN: 0962-8436, DOI: 10.1098/rstb.2016.0470
Philosophical Transactions of the Royal Society B: Biological Sciences 372/1736 2019-06-18
2017 Levi Yant, Kirsten Bomblies
Genomic studies of adaptive evolution in outcrossing Arabidopsis species
published pages: 9-14, ISSN: 1369-5266, DOI: 10.1016/j.pbi.2016.11.018
Current Opinion in Plant Biology 36 2019-06-18
2018 Andrew Lloyd, Chris Morgan, F. Chris H. Franklin, Kirsten Bomblies
Plasticity of Meiotic Recombination Rates in Response to Temperature in Arabidopsis
published pages: 1409-1420, ISSN: 0016-6731, DOI: 10.1534/genetics.117.300588
Genetics 208/4 2019-05-20
2018 Monnahan, P., Kolář, F., Baduel, P., Sailer, C., Koch, J., Horvath, R., Laenen, B., Schmickl, R., Paajanen, P., Šrámková, G., Bohutínská, M., Arnold, B., Weisman, C. M., Marhold, K., Slotte, T., Bomblies, K., Yant, L.
Pervasive population genomic consequences of genome duplication in Arabidopsis arenosa
published pages: , ISSN: , DOI: 10.1101/411041
BioRXiv 2019-05-20

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