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Widefield Raman imaging probe for intraoperative margin assessment of cancers

Total Cost €


EC-Contrib. €






 IMAGINE project word cloud

Explore the words cloud of the IMAGINE project. It provides you a very rough idea of what is the project "IMAGINE" about.

receiver    international    clinical    spectroscopy    sensitivity    surgery    2800    tissues    compatible    survival    offers    camera    infrared    mobility    resection    avenues    modality    selectively    colorectal    clear    obtaining    risk    innovative    visualisation    imaging    standard    secondment    cm    cancer    prototype    constituents    ex    settings    raman    tissue    combination    excellence    widefield    bioimaging    band    fosters    pass    scientific    histopathology    endogenous    imagine    progression    laparoscopic    optical    industrial    margin    wavenumber    vivo    engineering    excised    bioengineering    mechanism    benefit    ultimately    tumour    inelastic    broadly    patients    serve    fpa    biomolecular    first    applicable    focal    contrast    scattering    margins    intraoperative    near    sensitive    multidisciplinary    molecular    translationally    nir    light    ultra    surgical    gold    specificy    constitutes    free    disease    probe    biopsy    strengthen    3600    array    lesions    plane    rocs    invasive    cancers    positive    filters    ingaas    label    technique    cancerous   

Project "IMAGINE" data sheet

The following table provides information about the project.


Organization address
city: LONDON
postcode: SW7 2AZ

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

'Positive cancerous margins after surgery lead to an increased risk of progression and reduced disease free survival. Obtaining clear margins of cancerous lesions can be very challenging during surgery. Raman spectroscopy is a unique label-free optical technique based on inelastic light scattering that offers tissue 'optical biopsy' at the molecular level. IMAGINE is a multidisciplinary approach that aims to develop the first widefield near-infrared (NIR) Raman imaging probe for intraoperative margin assessment. A new ultra-high sensitive InGaAs focal plane array (FPA) camera integrated with a novel combination of band-pass filters will be integrated to selectively probe the biomolecular constituents of tissues in the high-wavenumber range (i.e., 2800-3600 cm-1) providing a new endogenous biomolecular contrast mechanism for visualisation of resection margins during cancer surgery. A prototype will be developed and applied ex vivo on excised tissues from colorectal cancer patients. Histopathology will serve as gold standard and the sensitivity, specificy, receiver operating characteristics (ROCs), tumour contrast, and potential clinical/surgical impact will be evaluated. The new optical bioimaging modality proposed here constitutes a simple non-invasive cost-effective and broadly applicable technique for margin assessment of cancers compatible with in vivo laparoscopic settings. This translationally driven project fosters multidisciplinary research involving bioengineering, optical engineering and clinical research and has the support of a strong international industrial secondment. IMAGINE will enhance the mobility and innovative potential of the applicant and open new avenues in cancer surgery, which will strengthen the scientific excellence in Europe and ultimately benefit the patients.'


year authors and title journal last update
List of publications.
2017 Mads S. Bergholt, Michael B. Albro, Molly M. Stevens
Online quantitative monitoring of live cell engineered cartilage growth using diffuse fiber-optic Raman spectroscopy
published pages: 128-137, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2017.06.015
Biomaterials 140 2019-06-13
2017 Mads S. Bergholt, Andrea Serio, James S. McKenzie, Amanda Boyd, Renata F. Soares, Jocelyn Tillner, Ciro Chiappini, Vincen Wu, Andreas Dannhorn, Zoltan Takats, Anna Williams, Molly M. Stevens
Correlated Heterospectral Lipidomics for Biomolecular Profiling of Remyelination in Multiple Sclerosis
published pages: 39-51, ISSN: 2374-7943, DOI: 10.1021/acscentsci.7b00367
ACS Central Science 4/1 2019-06-13
2017 Charalambos Kallepitis, Mads S. Bergholt, Manuel M. Mazo, Vincent Leonardo, Stacey C. Skaalure, Stephanie A. Maynard, Molly M. Stevens
Quantitative volumetric Raman imaging of three dimensional cell cultures
published pages: 14843, ISSN: 2041-1723, DOI: 10.1038/ncomms14843
Nature Communications 8 2019-06-13
2017 Amanda Y. F. You, Mads S. Bergholt, Jean-Philippe St-Pierre, Worrapong Kit-Anan, Isaac J. Pence, Adrian H. Chester, Magdi H. Yacoub, Sergio Bertazzo, Molly M. Stevens
Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in the human aorta
published pages: e1701156, ISSN: 2375-2548, DOI: 10.1126/sciadv.1701156
Science Advances 3/12 2019-06-13

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The information about "IMAGINE" are provided by the European Opendata Portal: CORDIS opendata.

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