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IMAGINE SIGNED

Widefield Raman imaging probe for intraoperative margin assessment of cancers

Total Cost €

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EC-Contrib. €

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Partnership

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 IMAGINE project word cloud

Explore the words cloud of the IMAGINE project. It provides you a very rough idea of what is the project "IMAGINE" about.

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Project "IMAGINE" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website http://www.imperial.ac.uk/m.bergholt
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 183˙454.00

Map

 Project objective

'Positive cancerous margins after surgery lead to an increased risk of progression and reduced disease free survival. Obtaining clear margins of cancerous lesions can be very challenging during surgery. Raman spectroscopy is a unique label-free optical technique based on inelastic light scattering that offers tissue 'optical biopsy' at the molecular level. IMAGINE is a multidisciplinary approach that aims to develop the first widefield near-infrared (NIR) Raman imaging probe for intraoperative margin assessment. A new ultra-high sensitive InGaAs focal plane array (FPA) camera integrated with a novel combination of band-pass filters will be integrated to selectively probe the biomolecular constituents of tissues in the high-wavenumber range (i.e., 2800-3600 cm-1) providing a new endogenous biomolecular contrast mechanism for visualisation of resection margins during cancer surgery. A prototype will be developed and applied ex vivo on excised tissues from colorectal cancer patients. Histopathology will serve as gold standard and the sensitivity, specificy, receiver operating characteristics (ROCs), tumour contrast, and potential clinical/surgical impact will be evaluated. The new optical bioimaging modality proposed here constitutes a simple non-invasive cost-effective and broadly applicable technique for margin assessment of cancers compatible with in vivo laparoscopic settings. This translationally driven project fosters multidisciplinary research involving bioengineering, optical engineering and clinical research and has the support of a strong international industrial secondment. IMAGINE will enhance the mobility and innovative potential of the applicant and open new avenues in cancer surgery, which will strengthen the scientific excellence in Europe and ultimately benefit the patients.'

 Publications

year authors and title journal last update
List of publications.
2017 Mads S. Bergholt, Michael B. Albro, Molly M. Stevens
Online quantitative monitoring of live cell engineered cartilage growth using diffuse fiber-optic Raman spectroscopy
published pages: 128-137, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2017.06.015
Biomaterials 140 2019-06-13
2017 Mads S. Bergholt, Andrea Serio, James S. McKenzie, Amanda Boyd, Renata F. Soares, Jocelyn Tillner, Ciro Chiappini, Vincen Wu, Andreas Dannhorn, Zoltan Takats, Anna Williams, Molly M. Stevens
Correlated Heterospectral Lipidomics for Biomolecular Profiling of Remyelination in Multiple Sclerosis
published pages: 39-51, ISSN: 2374-7943, DOI: 10.1021/acscentsci.7b00367
ACS Central Science 4/1 2019-06-13
2017 Charalambos Kallepitis, Mads S. Bergholt, Manuel M. Mazo, Vincent Leonardo, Stacey C. Skaalure, Stephanie A. Maynard, Molly M. Stevens
Quantitative volumetric Raman imaging of three dimensional cell cultures
published pages: 14843, ISSN: 2041-1723, DOI: 10.1038/ncomms14843
Nature Communications 8 2019-06-13
2017 Amanda Y. F. You, Mads S. Bergholt, Jean-Philippe St-Pierre, Worrapong Kit-Anan, Isaac J. Pence, Adrian H. Chester, Magdi H. Yacoub, Sergio Bertazzo, Molly M. Stevens
Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in the human aorta
published pages: e1701156, ISSN: 2375-2548, DOI: 10.1126/sciadv.1701156
Science Advances 3/12 2019-06-13

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The information about "IMAGINE" are provided by the European Opendata Portal: CORDIS opendata.

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