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Connectivity in the neural control of muscles in stroke patients.

Total Cost €


EC-Contrib. €






Project "NeuralCon" data sheet

The following table provides information about the project.


Organization address
address: PIAZZA MERCATO 15
postcode: 25121

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2018-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The lack of objective and robust measurements of motor recovery is a general problem in stroke rehabilitation. After the ischemic event, the motor impairment is assessed using clinical scales that provide only a general overview of the patient’s conditions, without detailed information on the activation of the individual muscles and the pathological co-contractions. In recent years, the hypothesis that the coordination of multiple muscles is wired at the neural level in a synergistic way has received strong experimental evidence. Therefore, the possibility to better understand the recruitment of multiple muscles and use this information for the assessment of motor recovery is extremely relevant for stroke rehabilitation. The project NeuralCon aims to investigate the neural mechanisms behind the control of multiple muscles of the lower limb in healthy individuals and its degeneration in acute stroke patients. The project will address the characterization of the neural coupling between muscles using innovative signal processing approaches applied to the high-density surface electromiographic signals during voluntary contractions. From the electromiographic signals, we will extract information regarding the coupling between multiple motor neurons in different motor pools. The final aim will be the development of a new generation of biomarkers based on the concurrent neural activation of several muscles in the lower limb of acute stroke individuals. The project will combine expertise in several fields: neuroscience of human movement, clinical neurophysiology, stochastic signal processing and computational neuroscience. The NeuralCon project will produce substantial progress toward a better understanding of the neural pathways involved in the coordination of voluntary movements and its modifications in cerebrovascular diseases.


year authors and title journal last update
List of publications.
2017 Francesco Negro, Claudio Orizio
Robust estimation of average twitch contraction forces of populations of motor units in humans
published pages: , ISSN: 1050-6411, DOI: 10.1016/j.jelekin.2017.10.005
Journal of Electromyography and Kinesiology 2019-06-13
2017 E. Martinez-Valdes, F. Negro, C. M. Laine, D. Falla, F. Mayer, D. Farina
Tracking motor units longitudinally across experimental sessions with high-density surface electromyography
published pages: 1479-1496, ISSN: 0022-3751, DOI: 10.1113/JP273662
The Journal of Physiology 595/5 2019-06-13
2018 Lin Xu, Francesco Negro, Yu Xu, Chiara Rabotti, Goof Schep, Dario Farina, Massimo Mischi
Does vibration superimposed on low-level isometric contraction alter motor unit recruitment strategy?
published pages: 66001, ISSN: 1741-2560, DOI: 10.1088/1741-2552/aadc43
Journal of Neural Engineering 15/6 2019-05-09
2018 Francesco Negro, Marta Cogliati, Alessandro Cudicio, Luciano Bissolotti, Claudio Orizio
Neural Biomarkers of Functional Recovery in Patients with Injured Motor System
published pages: 907-910, ISSN: , DOI: 10.1007/978-3-030-01845-0_182
2018 Christopher K. Thompson, Francesco Negro, Michael D. Johnson, Matthew R. Holmes, Laura Miller McPherson, Randall K. Powers, Dario Farina, Charles J. Heckman
Robust and accurate decoding of motoneuron behaviour and prediction of the resulting force output
published pages: 2643-2659, ISSN: 0022-3751, DOI: 10.1113/jp276153
The Journal of Physiology 596/14 2019-05-09
2018 Utku Åž. Yavuz, Francesco Negro, Robin Diedrichs, Dario Farina
Reciprocal inhibition between motor neurons of the tibialis anterior and triceps surae in humans
published pages: 1699-1706, ISSN: 0022-3077, DOI: 10.1152/jn.00424.2017
Journal of Neurophysiology 119/5 2019-05-09
2018 Sohail Siadatnejad, Francesco Negro, Luca Citi
Hybrid Gaussian Point-Process Model for Finer Control of Myoelectric Robotic Hands
published pages: 137-140, ISSN: , DOI: 10.1007/978-3-030-01845-0_27
2018 Eduardo Martinez-Valdes, Francesco Negro, Deborah Falla, Alessandro Marco De Nunzio, Dario Farina
Surface electromyographic amplitude does not identify differences in neural drive to synergistic muscles
published pages: 1071-1079, ISSN: 8750-7587, DOI: 10.1152/japplphysiol.01115.2017
Journal of Applied Physiology 124/4 2019-05-09
2018 Spencer A. Murphy, Francesco Negro, Dario Farina, Tanya Onushko, Matthew J. Durand, Sandra K. Hunter, Brian D. Schmit, Allison S. Hyngstrom
Stroke Increases Ischemia-related Decreases in Motor Unit Discharge Rates
published pages: , ISSN: 0022-3077, DOI: 10.1152/jn.00923.2017
Journal of Neurophysiology 2019-05-09
2017 Alessandro Del Vecchio, Francesco Negro, Francesco Felici, Dario Farina
Associations between motor unit action potential parameters and surface EMG features
published pages: 835-843, ISSN: 8750-7587, DOI: 10.1152/japplphysiol.00482.2017
Journal of Applied Physiology 123/4 2019-05-09
2017 Dario Farina, Ivan Vujaklija, Massimo Sartori, Tamás Kapelner, Francesco Negro, Ning Jiang, Konstantin Bergmeister, Arash Andalib, Jose Principe, Oskar C. Aszmann
Man/machine interface based on the discharge timings of spinal motor neurons after targeted muscle reinnervation
published pages: 25, ISSN: 2157-846X, DOI: 10.1038/s41551-016-0025
Nature Biomedical Engineering 1/2 2019-05-09
2018 Jakob L. Dideriksen, Francesco Negro, Deborah Falla, Signe R. Kristensen, Natalie Mrachacz-Kersting, Dario Farina
Coherence of the Surface EMG and Common Synaptic Input to Motor Neurons
published pages: , ISSN: 1662-5161, DOI: 10.3389/fnhum.2018.00207
Frontiers in Human Neuroscience 12 2019-05-09
2018 Allison S. Hyngstrom, Spencer A. Murphy, Jennifer Nguyen, Brian D. Schmit, Francesco Negro, David D. Gutterman, Matthew J. Durand
Ischemic conditioning increases strength and volitional activation of paretic muscle in chronic stroke: a pilot study
published pages: 1140-1147, ISSN: 8750-7587, DOI: 10.1152/japplphysiol.01072.2017
Journal of Applied Physiology 124/5 2019-05-09
2018 Jakob L. Dideriksen, Francesco Negro
Spike-triggered averaging provides inaccurate estimates of motor unit twitch properties under optimal conditions
published pages: 104-110, ISSN: 1050-6411, DOI: 10.1016/j.jelekin.2018.09.008
Journal of Electromyography and Kinesiology 43 2019-05-09
Early Motor Unit Conduction Velocity Changes to High-Intensity Interval Training versus Continuous Training
published pages: 2339-2350, ISSN: 0195-9131, DOI: 10.1249/MSS.0000000000001705
Medicine & Science in Sports & Exercise 50/11 2019-05-09
2018 A. Del Vecchio, F. Negro, D. Falla, I. Bazzucchi, D. Farina, F. Felici
Higher muscle fiber conduction velocity and early rate of torque development in chronically strength-trained individuals
published pages: 1218-1226, ISSN: 8750-7587, DOI: 10.1152/japplphysiol.00025.2018
Journal of Applied Physiology 125/4 2019-05-09
2017 Javier Rodriguez-Falces, Francesco Negro, Dario Farina
Correlation between discharge timings of pairs of motor units reveals the presence but not the proportion of common synaptic input to motor neurons
published pages: 1749-1760, ISSN: 0022-3077, DOI: 10.1152/jn.00497.2016
Journal of Neurophysiology 117/4 2019-05-09
2018 A. Del Vecchio, F. Negro, F. Felici, D. Farina
Distribution of muscle fibre conduction velocity for representative samples of motor units in the full recruitment range of the tibialis anterior muscle
published pages: e12930, ISSN: 1748-1708, DOI: 10.1111/apha.12930
Acta Physiologica 222/2 2019-05-09

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The information about "NEURALCON" are provided by the European Opendata Portal: CORDIS opendata.

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