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Finch Evo-Devo SIGNED

Developmental Basis of Beak Shape Variation in Darwin’s Finches

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Finch Evo-Devo project word cloud

Explore the words cloud of the Finch Evo-Devo project. It provides you a very rough idea of what is the project "Finch Evo-Devo" about.

shapes    principles    transcripts    morphogenesis    transcriptome    generate    textbook    insights    functional    beak    expression    extensive    colleagues    combination    arkhat    intrinsic    reveal    screen    shape    opportunity    sequencing    extremely    employ    gain    community    ecological    adaptive    molecules    actual    genome    scaling    phenotype    interdisciplinary    variation    display    embryos    zebrafinch    vectors    natural    roles    revealed    previously    darwin    regulators    radiation    morphological    function    gwas    morphometrics    retroviral    genetic    rnaseq    basic    groups    chicken    finches    complemented    saltational    niches    molecular    enormous    transformation    group    tests    dr    valuable    diversification    validate    diversity    underlying    search    upstream    association    gene    causing    entire    interactions    effector    supervisor    leaps    classic    developmental    mechanisms    abzhanov    biological    candidates    showed    occupation    programs    curvatures    shear   

Project "Finch Evo-Devo" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 183˙454.00

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 Project objective

Darwin’s finches display an extremely high beak shape diversity associated with occupation of various ecological niches. They are the classic textbook example of adaptive radiation under natural selection. The supervisor of this proposal – Dr. Arkhat Abzhanov and colleagues previously used a combination of morphometrics, comparative developmental genetic and functional tests to reveal basic principles underlying beak shape morphogenesis. They showed that the enormous beak diversity in Darwin’s finches could be reduced to three “group shapes” (A, B, and C) and revealed molecular mechanisms causing the scaling–based variation within group “A”, but not yet the processes underlying the more complex shear-based saltational transformation that produced variation between groups. The main objective of this project is to identify the developmental programs underlying the leaps of beak shape diversification during Darwin’s finches’ adaptive radiation – the variation between “group shapes”. I will employ an extensive whole-transcriptome sequencing (RNAseq) screen to search for novel transcripts whose gene expression is associated with the group shape-specific beak curvatures. This will be complemented with genome-wide association study (GWAS) to identify upstream regulators of the actual effector molecules that cause the phenotype. I will validate the best candidates by gain- and loss-of-function tests using retroviral vectors on developing chicken and zebrafinch embryos to reveal their roles in beak morphogenesis. This project will provide novel insights on intrinsic mechanisms that facilitate adaptive morphological diversity, will offer an opportunity for interdisciplinary research interactions and will generate resources valuable to the entire biological community.

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