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Finch Evo-Devo SIGNED

Developmental Basis of Beak Shape Variation in Darwin’s Finches

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Finch Evo-Devo project word cloud

Explore the words cloud of the Finch Evo-Devo project. It provides you a very rough idea of what is the project "Finch Evo-Devo" about.

transformation    upstream    reveal    morphometrics    transcripts    genetic    chicken    vectors    combination    opportunity    molecules    regulators    curvatures    textbook    diversification    adaptive    screen    roles    leaps    search    biological    candidates    zebrafinch    extensive    shape    shear    scaling    interactions    valuable    developmental    abzhanov    enormous    embryos    intrinsic    display    entire    finches    diversity    sequencing    underlying    principles    gwas    retroviral    mechanisms    generate    effector    association    programs    classic    natural    colleagues    variation    groups    niches    revealed    complemented    basic    arkhat    validate    actual    employ    previously    saltational    molecular    supervisor    extremely    showed    interdisciplinary    gene    radiation    gain    morphological    genome    transcriptome    insights    phenotype    dr    function    rnaseq    ecological    community    morphogenesis    beak    group    occupation    tests    expression    causing    shapes    functional    darwin   

Project "Finch Evo-Devo" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 183˙454.00

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 Project objective

Darwin’s finches display an extremely high beak shape diversity associated with occupation of various ecological niches. They are the classic textbook example of adaptive radiation under natural selection. The supervisor of this proposal – Dr. Arkhat Abzhanov and colleagues previously used a combination of morphometrics, comparative developmental genetic and functional tests to reveal basic principles underlying beak shape morphogenesis. They showed that the enormous beak diversity in Darwin’s finches could be reduced to three “group shapes” (A, B, and C) and revealed molecular mechanisms causing the scaling–based variation within group “A”, but not yet the processes underlying the more complex shear-based saltational transformation that produced variation between groups. The main objective of this project is to identify the developmental programs underlying the leaps of beak shape diversification during Darwin’s finches’ adaptive radiation – the variation between “group shapes”. I will employ an extensive whole-transcriptome sequencing (RNAseq) screen to search for novel transcripts whose gene expression is associated with the group shape-specific beak curvatures. This will be complemented with genome-wide association study (GWAS) to identify upstream regulators of the actual effector molecules that cause the phenotype. I will validate the best candidates by gain- and loss-of-function tests using retroviral vectors on developing chicken and zebrafinch embryos to reveal their roles in beak morphogenesis. This project will provide novel insights on intrinsic mechanisms that facilitate adaptive morphological diversity, will offer an opportunity for interdisciplinary research interactions and will generate resources valuable to the entire biological community.

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