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PrecTherLSCC

Precision Therapies in Lung Squamous Cell Carcinoma

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PrecTherLSCC project word cloud

Explore the words cloud of the PrecTherLSCC project. It provides you a very rough idea of what is the project "PrecTherLSCC" about.

nck    molecular    40    amplified    serve    annually    cell    20    aid    biomarker    confirm    functional    calibre    lung    therapies    stepwise    overexpressed    cells    proteomics    disease    identification    interacting    transferable    patients    leadership    traf    gene    communication    samples    torres    data    progression    small    options    almost    oncogenic    preclinical    signalling    xenograft    treatment    molecule    ayuso    validate    550    position    scarce    benefit    critical    obtaining    supervisor    tnik    models    vivo    precise    modulates    contribution    unmet    cancer    biology    expression    multidisciplinary    squamous    young    carcinoma    select    diagnosed    phenotypes    inhibitors    assays    mechanisms    intervention    levels    fellow    brognard    competitive    substrates    broaden    manchester    scientist    kinase    xenografts    pro    genetic    dr    patient    mentoring    expertise    he    therapeutic    preliminary    worldwide    tumours    drivers    organoids    lscc    uk    skills    constitutes   

Project "PrecTherLSCC" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2018-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 183˙454.00

Map

 Project objective

Lung squamous cell carcinoma (LSCC) represents one third of lung tumours; 550,000 cases are diagnosed annually worldwide (20% occur in Europe). Treatment options for this cancer type are still scarce. Identification of LSCC genetic drivers is thus an essential unmet need for developing novel therapies for this disease.

In a stepwise multidisciplinary approach, we will determine if TNIK (Traf-2 and Nck-interacting kinase), a gene amplified in almost 40% of LSCC cases, constitutes a therapeutic target for the treatment of LSCC patients. Our preliminary data show that TNIK is overexpressed in LSCC cells, in which it has a pro-oncogenic role. Using proteomics approaches and functional assays, we will define the molecular mechanisms and critical signalling pathways that TNIK modulates to promote LSCC progression. In xenograft models we will confirm the contribution of TNIK to the studied phenotypes in vivo. We will analyse TNIK levels and activity (after identification of substrates) in patient samples, and will aim to validate TNIK as a target for therapeutic intervention using small molecule TNIK inhibitors in novel preclinical models: LSCC organoids and patient-derived xenografts. Finally, we will assess if increased TNIK expression can serve as a biomarker to select patients that would benefit from treatment with TNIK inhibitors. Our studies will increase our knowledge on LSCC biology and aim to find a precise treatment for this disease.

This project will enable Dr P Torres-Ayuso to develop a wide range of new and transferable skills, and will allow him to broaden his technical, mentoring, management and communication skills. He will benefit from the high calibre of the Cancer Research UK Manchester Institute, and the expertise of his supervisor (Dr J Brognard) who will aid in his development as a young scientist. This project will thus enable the Fellow to achieve his long-term objective of obtaining a leadership position in a competitive European Institute.

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The information about "PRECTHERLSCC" are provided by the European Opendata Portal: CORDIS opendata.

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