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PrecTherLSCC

Precision Therapies in Lung Squamous Cell Carcinoma

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PrecTherLSCC project word cloud

Explore the words cloud of the PrecTherLSCC project. It provides you a very rough idea of what is the project "PrecTherLSCC" about.

disease    squamous    calibre    signalling    assays    functional    data    identification    vivo    pro    manchester    young    multidisciplinary    serve    proteomics    benefit    kinase    preclinical    fellow    traf    substrates    competitive    expression    molecular    lung    tumours    uk    550    treatment    genetic    preliminary    samples    drivers    interacting    20    confirm    position    molecule    diagnosed    ayuso    progression    40    communication    lscc    models    mechanisms    organoids    scarce    small    levels    patients    therapeutic    xenograft    transferable    mentoring    therapies    leadership    obtaining    intervention    scientist    annually    biomarker    skills    almost    amplified    dr    overexpressed    inhibitors    cancer    cell    stepwise    carcinoma    precise    supervisor    cells    unmet    gene    phenotypes    constitutes    validate    critical    worldwide    options    tnik    contribution    torres    he    modulates    broaden    expertise    brognard    biology    nck    aid    xenografts    select    oncogenic    patient   

Project "PrecTherLSCC" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2018-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 183˙454.00

Map

 Project objective

Lung squamous cell carcinoma (LSCC) represents one third of lung tumours; 550,000 cases are diagnosed annually worldwide (20% occur in Europe). Treatment options for this cancer type are still scarce. Identification of LSCC genetic drivers is thus an essential unmet need for developing novel therapies for this disease.

In a stepwise multidisciplinary approach, we will determine if TNIK (Traf-2 and Nck-interacting kinase), a gene amplified in almost 40% of LSCC cases, constitutes a therapeutic target for the treatment of LSCC patients. Our preliminary data show that TNIK is overexpressed in LSCC cells, in which it has a pro-oncogenic role. Using proteomics approaches and functional assays, we will define the molecular mechanisms and critical signalling pathways that TNIK modulates to promote LSCC progression. In xenograft models we will confirm the contribution of TNIK to the studied phenotypes in vivo. We will analyse TNIK levels and activity (after identification of substrates) in patient samples, and will aim to validate TNIK as a target for therapeutic intervention using small molecule TNIK inhibitors in novel preclinical models: LSCC organoids and patient-derived xenografts. Finally, we will assess if increased TNIK expression can serve as a biomarker to select patients that would benefit from treatment with TNIK inhibitors. Our studies will increase our knowledge on LSCC biology and aim to find a precise treatment for this disease.

This project will enable Dr P Torres-Ayuso to develop a wide range of new and transferable skills, and will allow him to broaden his technical, mentoring, management and communication skills. He will benefit from the high calibre of the Cancer Research UK Manchester Institute, and the expertise of his supervisor (Dr J Brognard) who will aid in his development as a young scientist. This project will thus enable the Fellow to achieve his long-term objective of obtaining a leadership position in a competitive European Institute.

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The information about "PRECTHERLSCC" are provided by the European Opendata Portal: CORDIS opendata.

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