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PrecTherLSCC

Precision Therapies in Lung Squamous Cell Carcinoma

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PrecTherLSCC project word cloud

Explore the words cloud of the PrecTherLSCC project. It provides you a very rough idea of what is the project "PrecTherLSCC" about.

small    patient    traf    transferable    tumours    20    40    supervisor    cancer    signalling    xenograft    overexpressed    options    substrates    constitutes    critical    expertise    interacting    he    ayuso    annually    genetic    functional    pro    mechanisms    drivers    tnik    preclinical    uk    diagnosed    disease    benefit    assays    patients    expression    cell    manchester    worldwide    proteomics    levels    aid    intervention    lung    models    therapies    phenotypes    serve    data    communication    amplified    contribution    scientist    brognard    treatment    identification    young    progression    calibre    mentoring    preliminary    550    multidisciplinary    squamous    biology    samples    leadership    obtaining    skills    therapeutic    broaden    inhibitors    organoids    validate    carcinoma    stepwise    molecule    gene    unmet    precise    torres    confirm    modulates    position    cells    vivo    nck    select    xenografts    oncogenic    fellow    lscc    dr    biomarker    competitive    scarce    molecular    almost    kinase   

Project "PrecTherLSCC" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2018-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 183˙454.00

Map

 Project objective

Lung squamous cell carcinoma (LSCC) represents one third of lung tumours; 550,000 cases are diagnosed annually worldwide (20% occur in Europe). Treatment options for this cancer type are still scarce. Identification of LSCC genetic drivers is thus an essential unmet need for developing novel therapies for this disease.

In a stepwise multidisciplinary approach, we will determine if TNIK (Traf-2 and Nck-interacting kinase), a gene amplified in almost 40% of LSCC cases, constitutes a therapeutic target for the treatment of LSCC patients. Our preliminary data show that TNIK is overexpressed in LSCC cells, in which it has a pro-oncogenic role. Using proteomics approaches and functional assays, we will define the molecular mechanisms and critical signalling pathways that TNIK modulates to promote LSCC progression. In xenograft models we will confirm the contribution of TNIK to the studied phenotypes in vivo. We will analyse TNIK levels and activity (after identification of substrates) in patient samples, and will aim to validate TNIK as a target for therapeutic intervention using small molecule TNIK inhibitors in novel preclinical models: LSCC organoids and patient-derived xenografts. Finally, we will assess if increased TNIK expression can serve as a biomarker to select patients that would benefit from treatment with TNIK inhibitors. Our studies will increase our knowledge on LSCC biology and aim to find a precise treatment for this disease.

This project will enable Dr P Torres-Ayuso to develop a wide range of new and transferable skills, and will allow him to broaden his technical, mentoring, management and communication skills. He will benefit from the high calibre of the Cancer Research UK Manchester Institute, and the expertise of his supervisor (Dr J Brognard) who will aid in his development as a young scientist. This project will thus enable the Fellow to achieve his long-term objective of obtaining a leadership position in a competitive European Institute.

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The information about "PRECTHERLSCC" are provided by the European Opendata Portal: CORDIS opendata.

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