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a-Sign SIGNED

Cyclic nucleotide signalling in the human pathogen Listeria monocytogenes

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "a-Sign" data sheet

The following table provides information about the project.

Coordinator
INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC 

Organization address
address: RUA ALFREDO ALLEN 208
city: PORTO
postcode: 4200 135
website: www.ibmc.up.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website https://www.i3s.up.pt/molecular-microbiology
 Total cost 148˙635 €
 EC max contribution 148˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC PT (PORTO) coordinator 148˙635.00

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 Project objective

Nucleotides are the building blocks of nucleic acids and have emerged as significant determinants in energy transfer and signalling. Four nucleotides are known to function as signalling molecules in bacteria, namely the cyclic mono-nucleotides cAMP and cGMP, and the cyclic di-nucleotides c-di-AMP and c-di-GMP. These molecules play specific and distinct roles in many bacterial species, and can co-exist within a single bacterial cell. Whereas the diversity of cyclic nucleotide signalling is now starting to be uncovered, very little is known about their coordination in the control of their respective signalling pathways. Specifically, in the human pathogen Listeria monocytogenes, agent of a life-threatening and foodborne disease, it is known that both cyclic di-nucleotides c-di-AMP and c-di-GMP are produced but the production of cAMP and cGMP, as well as the contribution of the four nucleotides to the virulence mechanisms deployed by L. monocytogenes is yet to be uncovered. Using multidisciplinary approaches, the present proposal aims to 1) investigate the production of cAMP and cGMP, 2) identify new signalling pathways governed by the different cyclic nucleotides, and 3) uncover their role in physiology and pathogenesis. The overall impact of this proposal can open up the field to novel concepts and provide a basis for the study of cyclic nucleotide crosstalk.

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