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FORGENET

A novel approach for detecting polygenic adaptation applied to FORest tree candidate GEne NETworks

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

FORGENET project word cloud

Explore the words cloud of the FORGENET project. It provides you a very rough idea of what is the project "FORGENET" about.

interaction regarding ample perpetual genomic members evolution species disequilibrium conifers events polygenic null endangered mediterranean drought networks adaptations data flowering independently small adaptive forgenet populations trees act tissue forest unravelling offers neutrality nevertheless evolutionary hypothesis estimating detecting spruces netadapt paradigm mechanisms radically coniferous climate statistics tolerance genotyped straightforward view traits linkage associations latitudinal adapt genotype construct potentially proposes epistatic gradients network published play genetics reached pine experimental interactions detect lacking time adaptability topology environments changing haploid shift functional acts multiple natural seems gene inherent exploits agreed first candidate genes indicates genotyping

Project "FORGENET" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAT ZURICH Organization address address: RAMISTRASSE 71 city: ZURICH postcode: 8006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Project website	https://sites.google.com/site/katalincsillery/research/forgenet
Total cost	175˙419 €
EC max contribution	175˙419 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2019-10-01

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAT ZURICH UNIVERSITAT ZURICH Organization address address: RAMISTRASSE 71 city: ZURICH postcode: 8006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZURICH)	coordinator	175˙419.00

Map

Project objective

Unravelling the mechanisms of selection that allow species to adapt to changing environments has been a perpetual goal of evolutionary genetics. A current paradigm shift seems to radically change our view regarding the major mechanisms of evolutionary change. Ample experimental data indicates that most traits that potentially play a role in adaptations are controlled by many genes that may not act independently, but as members of complex gene interaction networks. Thus, it is widely agreed that most adaptation events in natural populations are reached via so-called polygenic adaptation, involving small changes at multiple genes at a time. Nevertheless, methods are still lacking to detect such adaptive gene associations. The main objective of FORGENET is to propose NetAdapt, a network-based test of polygenic selection for candidate-gene data. NetAdapt exploits candidate-gene data both as genotype and functional genomic data. First, based on the functional genomic information inherent to candidate gene data, it proposes to construct a gene interaction network, whose topology can be used to define a null hypothesis of neutrality. Second, based on the genotype data, it proposes a test for detecting selection on gene interactions, i.e. epistatic selection, based on linkage disequilibrium statistics. NetAdapt is expected to enhance our understanding how selection acts on gene networks and to propose new candidate genes for future genotyping. NetAdapt will be applied to published data on coniferous forest trees that have been genotyped from haploid tissue, which offers a straightforward application. Many conifers are endangered by climate change and estimating their adaptability is an important European research priority. FORGENET will study the evolution of flowering time genes at spruces along latitudinal gradients, and drought tolerance in Mediterranean pine species.

Publications

List of publications.
year	authors and title	journal	last update
2018	Katalin CsillÃ©ry, Alejandra RodrÃguez-Verdugo, Christian Rellstab, FrÃ©dÃ©ric Guillaume Detecting the genomic signal of polygenic adaptation and the role of epistasis in evolution published pages: 606-612, ISSN: 0962-1083, DOI: 10.1111/mec.14499	Molecular Ecology 27/3	2020-03-11
2019	Katalin CsillÃ©ry, Otso Ovaskainen, Christoph Sperisen, Nina Buchmann, Alex Widmer, Felix Gugerli Adaptation to local climate in multi-trait space: evidence from silver fir (Abies alba Mill.) populations across a heterogeneous environment published pages: , ISSN: 0018-067X, DOI: 10.1038/s41437-019-0240-0	Heredity	2020-03-11

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