Explore the words cloud of the PIM PROTEOMICS project. It provides you a very rough idea of what is the project "PIM PROTEOMICS" about.
The following table provides information about the project.
UNIVERSITY OF DUNDEE
|Coordinator Country||United Kingdom [UK]|
|Total cost||183˙454 €|
|EC max contribution||183˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-07-01 to 2019-07-13|
Take a look of project's partnership.
|1||UNIVERSITY OF DUNDEE||UK (DUNDEE)||coordinator||183˙454.00|
Understanding how T cells integrate alternative signal combinations to determine immune response strength and functionality is of critical importance for rational design of immunomodulatory therapies. The PIM kinase family have been identified as important regulators of cell division, survival and protein synthesis independent of, but in parallel to the key signalling molecule mTOR. I propose to use cutting-edge quantitative proteomic technology to identify substrates and downstream protein networks regulated by PIM kinase in activated T cells. I will investigate where these downstream targets qualitatively diverge from, or quantitatively interact with, the mTOR signalling pathway (Objective 1 and 2). Using advanced cell culture and mathematical modelling I will quantify how this co-ordinated activity regulates T cell division, survival and differentiation outcomes (Objective 3). This comprehensive exploration of PIM kinase and mTOR signalling pathway integration will provide important fundamental insight into how these signals combine to regulate T cell fate and may be manipulated in the context of immunotherapy or cancer.
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The information about "PIM PROTEOMICS" are provided by the European Opendata Portal: CORDIS opendata.
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