Opendata, web and dolomites

PACEMech TERMINATED

The structure and molecular mechanism of transport proteins within the PACE family of multidrug efflux pumps

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PACEMech project word cloud

Explore the words cloud of the PACEMech project. It provides you a very rough idea of what is the project "PACEMech" about.

worldwide    henderson    functional    genomics    colleagues    pathogen    data    experts    collective    interfere    acei    identification    extend    15    biocides    baumannii    paucity    family    vitro    conferred    collections    supervisor    bacterial    expert    greatest    biophysics    human    receive    reveal    regulation    proteins    collaborative    cell    proteobacterial    structural    health    draw    extensively    career    classically    play    drug    light    protein    multidrug    superfamilies    prof    function    broad    founding    details    describing    recognised    lasting    specialised    first    class    fundamental    antibiotics    actively    vision    transport    pathogens    remarkably    expertise    overcome    compound    powerful    strategies    antimicrobial    links    establishing    structure    conducting    training    acinetobacter    pumps    sixth    biochemical    export    biophysical    mechanism    mediate    pump    membrane    resistance    combination    peter    diverse    molecular    efflux    threats    hospital    mechanisms    families    representative    fellowship    laboratory    pace   

Project "PACEMech" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.astbury.leeds.ac.uk/people/staff/staffpage.php
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-09   to  2019-01-08

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 195˙454.00

Map

 Project objective

Antimicrobial resistance is recognised as one of the greatest threats to human health worldwide. Multidrug efflux pumps play a major role in the development of drug resistance in bacterial pathogens. These pumps are able to actively export remarkably broad collections antibiotics and biocides out of the cell. Multidrug efflux pumps have classically been organised into five distinct families or superfamilies. Due to their importance, representative proteins from each of these families have been extensively studied.

Using a combination of functional genomics and biochemical methods to study antimicrobial resistance in the hospital pathogen Acinetobacter baumannii, I recently identified AceI, the founding member of a sixth family of multidrug efflux pumps called the Proteobacterial Antimicrobial Compound Efflux (PACE) family. The PACE family is the first new family of efflux pumps to be described in 15 years. In light of its recent identification, there is a paucity of fundamental data describing how PACE family pumps mediate drug efflux. This proposal will apply in vitro biochemical, biophysical and structural analyses to reveal molecular details of the structure and functional transport mechanism operating in PACE family pumps.

This proposal will draw on the diverse collective expertise of my Fellowship Supervisor Prof Peter Henderson and his expert colleagues in membrane protein structural analyses and biophysics. In conducting this research I will build lasting collaborative links with these experts that will extend beyond the duration of this fellowship. I will receive specialised training in powerful membrane protein analysis methods that are essential to my career goal of establishing a leading research laboratory examining membrane transport proteins, from regulation to molecular mechanisms. My laboratory vision is to develop novel strategies to interfere with drug efflux pump function and so overcome resistance conferred by this important class of proteins.

 Publications

year authors and title journal last update
List of publications.
2018 Karl A. Hassan, Qi Liu, Liam D.H. Elbourne, Irshad Ahmad, David Sharples, Varsha Naidu, Chak Lam Chan, Liping Li, Steven P.D. Harborne, Alaska Pokhrel, Vincent L.G. Postis, Adrian Goldman, Peter J.F. Henderson, Ian T. Paulsen
Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens
published pages: , ISSN: 0923-2508, DOI: 10.1016/j.resmic.2018.01.001
Research in Microbiology 2019-06-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PACEMECH" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PACEMECH" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

SIMIS (2020)

Strongly Interacting Mass Imbalanced Superfluid with ultracold fermions

Read More  

IPG_CORE (2019)

Looking for the Impersonal Core -- Impersonal Pronouns across Germanic languages

Read More  

NPsVLCD (2019)

Natural Product-Inspired Therapies for Leishmaniasis and Chagas Disease

Read More