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PACEMech TERMINATED

The structure and molecular mechanism of transport proteins within the PACE family of multidrug efflux pumps

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PACEMech project word cloud

Explore the words cloud of the PACEMech project. It provides you a very rough idea of what is the project "PACEMech" about.

supervisor    baumannii    laboratory    antibiotics    drug    identification    transport    resistance    powerful    molecular    data    structural    details    actively    lasting    mediate    links    pace    acinetobacter    draw    combination    families    worldwide    collaborative    founding    peter    broad    export    colleagues    family    pump    representative    expert    extend    strategies    prof    collective    threats    establishing    recognised    regulation    compound    light    fundamental    describing    paucity    expertise    first    experts    collections    biophysics    extensively    superfamilies    pathogen    15    hospital    fellowship    antimicrobial    protein    human    vitro    genomics    proteins    diverse    training    classically    cell    proteobacterial    remarkably    mechanisms    play    efflux    specialised    function    conducting    career    greatest    henderson    reveal    overcome    biocides    class    vision    structure    functional    receive    sixth    bacterial    mechanism    biochemical    pathogens    acei    multidrug    interfere    biophysical    pumps    conferred    health    membrane   

Project "PACEMech" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.astbury.leeds.ac.uk/people/staff/staffpage.php
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-09   to  2019-01-08

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 195˙454.00

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 Project objective

Antimicrobial resistance is recognised as one of the greatest threats to human health worldwide. Multidrug efflux pumps play a major role in the development of drug resistance in bacterial pathogens. These pumps are able to actively export remarkably broad collections antibiotics and biocides out of the cell. Multidrug efflux pumps have classically been organised into five distinct families or superfamilies. Due to their importance, representative proteins from each of these families have been extensively studied.

Using a combination of functional genomics and biochemical methods to study antimicrobial resistance in the hospital pathogen Acinetobacter baumannii, I recently identified AceI, the founding member of a sixth family of multidrug efflux pumps called the Proteobacterial Antimicrobial Compound Efflux (PACE) family. The PACE family is the first new family of efflux pumps to be described in 15 years. In light of its recent identification, there is a paucity of fundamental data describing how PACE family pumps mediate drug efflux. This proposal will apply in vitro biochemical, biophysical and structural analyses to reveal molecular details of the structure and functional transport mechanism operating in PACE family pumps.

This proposal will draw on the diverse collective expertise of my Fellowship Supervisor Prof Peter Henderson and his expert colleagues in membrane protein structural analyses and biophysics. In conducting this research I will build lasting collaborative links with these experts that will extend beyond the duration of this fellowship. I will receive specialised training in powerful membrane protein analysis methods that are essential to my career goal of establishing a leading research laboratory examining membrane transport proteins, from regulation to molecular mechanisms. My laboratory vision is to develop novel strategies to interfere with drug efflux pump function and so overcome resistance conferred by this important class of proteins.

 Publications

year authors and title journal last update
List of publications.
2018 Karl A. Hassan, Qi Liu, Liam D.H. Elbourne, Irshad Ahmad, David Sharples, Varsha Naidu, Chak Lam Chan, Liping Li, Steven P.D. Harborne, Alaska Pokhrel, Vincent L.G. Postis, Adrian Goldman, Peter J.F. Henderson, Ian T. Paulsen
Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens
published pages: , ISSN: 0923-2508, DOI: 10.1016/j.resmic.2018.01.001
Research in Microbiology 2019-06-13

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