DENDRITIC PROCESSING

Local Processing of Dendritically Synthesized Membrane Proteins

 Coordinatore MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. 

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Dr.
Nome: Antje Maria
Cognome: Berken
Email: send email
Telefono: +48 69 5068202001
Fax: +48 69 5068202002

 Nazionalità Coordinatore Germany [DE]
 Totale costo 75˙000 €
 EC contributo 75˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-04-01   -   2015-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Dr.
Nome: Antje Maria
Cognome: Berken
Email: send email
Telefono: +48 69 5068202001
Fax: +48 69 5068202002

DE (MUENCHEN) coordinator 75˙000.00

Mappa


 Word cloud

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status    glycosylation    excitability    mrna    membrane    turnover    proteins    processed    channels    distal    largely    neurotransmitter    secretory    synthesized    protein    encoding    dendritic    organelles    dendritically    receptors    dendrites    synthesis    local    voltage    gated   

 Obiettivo del progetto (Objective)

'The local synthesis and degradation of proteins represent a particularly efficient means to adaptively modify the composition of targeted dendritic branches and associated synapses. Recent data from our laboratory show that numerous mRNA encoding neurotransmitter receptors and voltage-gated channels are enriched in distal dendrites, indicating that local translation sustains local membrane protein turnover and may thus regulate dendritic excitability. In contrast to cytoplasmic proteins, local production of cell-surface proteins requires their processing by the secretory apparatus. Although the list of dendritic mRNAs encoding membrane and secreted proteins keeps growing, whether and how dendritically synthesized membrane proteins are locally processed by secretory organelles is still largely elusive.

Here we propose to assess the dendritic synthesis and turnover of key neurotransmitter receptors and voltage-gated channels controlling dendritic excitability by combining genetic engineering and biochemical approaches to selectively label and purify nascent proteins in specified dendritic compartments. Furthermore, by analyzing their glycosylation status and controlling the targeting of their mRNA to distal dendrites, we aim to understand how dendritically synthesized membrane proteins are processed by dendritic secretory organelles.

The turnover and glycosylation status of neuronal ion channels in vivo is largely unknown. By assessing a large cast of synaptic receptors and voltage-gated channels, this project will hopefully allow important inferences to be made about local protein synthesis, glycosylation and protein stability in brain. In the longer run, the proposed research will enable us to focus later functional studies on molecules displaying rapid turnover, and thus more likely to be acutely affected by adaptive regulations of secretory functions.'

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