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CONNECT SIGNED

Connecting neuronal network activity with regional specificity for Alzheimer pathology: a multi-modal neuroimaging approach

Total Cost €

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EC-Contrib. €

0

Partnership

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Project "CONNECT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT MAASTRICHT 

Organization address
address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD
website: http://www.maastrichtuniversity.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://nmr.mgh.harvard.edu/lab/harvardagingbrain
 Total cost 174˙864 €
 EC max contribution 174˙864 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) coordinator 174˙864.00
2    THE GENERAL HOSPITAL CORPORATION US (BOSTON MA) partner 0.00

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 Project objective

As the world’s population is aging, the prevalence of Alzheimer’s disease (AD) is estimated to triple by 2050. Even though AD was identified more than 100 years ago, research has gained momentum only the last 30 years. To date, studies have mainly focused on the accumulation of two proteins, amyloid-beta and tau to understand the pathophysiology of this disease. In this project, I will take a new approach, by investigating the interaction between these two pathological hallmarks of AD and neuronal activity as a potential causal model for AD. The underlying hypothesis is that regional levels of neuronal activity determine the interaction between amyloid and tau pathology, and lead to AD symptomatology. To that end, I aim to combine novel molecular and state-of-the-art magnetic neuroimaging techniques with higher statistical modeling techniques. The group of Prof. Johnson at Massachusetts General Hospital (MGH) is currently the leading group pushing these techniques forward. The expertise within the lab of Prof. Johnson, his extensive network, the skills that I will acquire throughout this fellowship (scientifically and management-wise), combined with my existing level of expertise in MRI and my participation in diverse European networks will provide me with the competences to lead my own research group and establish a functional international multidisciplinary AD research network. Delaying or even treating this disease will require a multifactorial, multidisciplinary approach in which researchers combine resources, data and results in a coordinated manner worldwide. The implementation of these techniques in Europe and the subsequent close collaborations between European and American networks will have the highest chances to improve detection, prevention and treatment of AD.

 Publications

year authors and title journal last update
List of publications.
2019 Matthew J Betts, Evgeniya Kirilina, Maria C G Otaduy, Dimo Ivanov, Julio Acosta-Cabronero, Martina F Callaghan, Christian Lambert, Arturo Cardenas-Blanco, Kerrin Pine, Luca Passamonti, Clare Loane, Max C Keuken, Paula Trujillo, Falk Lüsebrink, Hendrik Mattern, Kathy Y Liu, Nikos Priovoulos, Klaus Fliessbach, Martin J Dahl, Anne Maaß, Christopher F Madelung, David Meder, Alexander J Ehrenberg, Ol
Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases
published pages: 2558-2571, ISSN: 0006-8950, DOI: 10.1093/brain/awz193
Brain 142/9 2020-04-24
2019 Fuller JT, Cronin-Golomb A, Gatchel JR, Norton DJ, Guzman-Velez E, Jacobs HIL, Hanseeuw B, Padilla-Delgado E, Artola A, Baena A, Bocanegra Y, Kosik KS, Chen K, Tariot PN, Johnson K, Sperling RA, Reiman EM, Lopera F, Quiroz YT
BIOLOGICAL AND COGNITIVE MARKERS OF PRESENILIN1 E280A AUTOSOMAL DOMINANT ALZHEIMER’S DISEASE: A COMPREHENSIVE REVIEW OF THE COLOMBIAN KINDRED
published pages: , ISSN: 2426-0266, DOI: 10.14283/jpad.2019.6
The Journal of Prevention of Alzheimer\'s disease 2020-03-05

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The information about "CONNECT" are provided by the European Opendata Portal: CORDIS opendata.

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