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RAMSES SIGNED

Aryl amide metallofoldamersas selective saccharide sensors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 RAMSES project word cloud

Explore the words cloud of the RAMSES project. It provides you a very rough idea of what is the project "RAMSES" about.

analogues    hydrogen    replacement    bonding    larger    modular    receptor    functional    first    oligoamide    building    molecules    recognition    evolutionary    consequently    converted    interactions    adhesion    exceptional    possessing    fluorescent    binding    immune    varied    starting    structural    iteratively    sequence    class    biological    ab    converge    size    bacteria    tumour    folded    substrate    exploits    synthesize    give    polar    selectivity    subsequent    metastasis    cell    cells    blocks    inform    frameworks    structure    slightly    roles    cavity    host    takes    iterative    single    defence    selective    devised    containing    drug    monosaccharides    plays    imaging    media    sequences    foldamer    metal    carbohydrate    capsules    elusive    place    differentiation    competitive    inflammatory    diagnostic    innovative    principles    rationally    characterization    initio    strategy    cellular    synthetic    discovery    refinements    sensors    fundamental    affinity    receptors    shape    oligomer    introducing    ions    viruses    complementarity    consists    aromatic    created    disorders    sensor    conjunction    helically   

Project "RAMSES" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.cnrs.fr/aquitaine/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 185˙076.00

Map

 Project objective

Carbohydrate recognition is fundamental in varied biological processes such as cellular differentiation, cell–cell interactions, immune defence and inflammatory response; consequently it plays key roles in tumour growth and metastasis, adhesion of viruses and bacteria to host cells and in immune and inflammatory disorders. It is well established that carbohydrate-binding molecules will have a strong impact on the development of new diagnostic and imaging methods and give rise to new opportunities for drug discovery. However the ab initio design of synthetic receptors for monosaccharides still remains an elusive objective, in particular if recognition is to take place in highly competitive polar media. This project aims to rationally design and synthesize single helically folded aromatic oligoamide capsules containing metal ions in order to achieve high affinity and selectivity for monosaccharides in polar media and to further develop them into functional fluorescent sensors. By introducing metal ions into foldamer frameworks a highly innovative class of receptors will be created which are expected to have exceptional binding abilities in polar media. The devised strategy consists in an iterative design process that exploits the modular structure of folded synthetic oligomer sequences in conjunction with structural characterization to inform subsequent refinements. Starting with a slightly larger than needed cavity possessing first-principles design that takes into account features such as size, shape and hydrogen bonding ability, the cavity size can iteratively be reduced while increasing shape complementarity with the substrate. With this evolutionary process the sequence will quickly converge towards a highly selective receptor for the target, which after replacement of key building blocks by fluorescent analogues, will be converted into a highly selective sensor.

 Publications

year authors and title journal last update
List of publications.
2017 Pedro Mateus, Barbara Wicher, Yann Ferrand, Ivan Huc
Alkali and alkaline earth metal ion binding by a foldamer capsule: selective recognition of magnesium hydrate
published pages: 9300-9303, ISSN: 1359-7345, DOI: 10.1039/C7CC05422J
Chemical Communications 53/67 2019-06-13
2018 Pedro Mateus, Barbara Wicher, Yann Ferrand, Ivan Huc
Carbohydrate binding through first- and second-sphere coordination within aromatic oligoamide metallofoldamers
published pages: 5078-5081, ISSN: 1359-7345, DOI: 10.1039/C8CC02360C
Chemical Communications 54/40 2019-06-13

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