Opendata, web and dolomites

RAMSES SIGNED

Aryl amide metallofoldamersas selective saccharide sensors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 RAMSES project word cloud

Explore the words cloud of the RAMSES project. It provides you a very rough idea of what is the project "RAMSES" about.

blocks    tumour    monosaccharides    affinity    substrate    media    polar    capsules    oligoamide    shape    cellular    introducing    sequence    replacement    class    containing    binding    cavity    plays    metastasis    iterative    slightly    defence    characterization    building    inform    functional    oligomer    fluorescent    size    host    selective    larger    structural    ab    receptors    rationally    bacteria    hydrogen    exploits    principles    ions    evolutionary    interactions    converted    disorders    competitive    helically    cell    refinements    sequences    aromatic    differentiation    analogues    takes    possessing    inflammatory    strategy    viruses    created    frameworks    elusive    molecules    iteratively    first    starting    biological    complementarity    give    diagnostic    drug    devised    carbohydrate    discovery    fundamental    converge    selectivity    foldamer    structure    roles    synthetic    sensor    innovative    initio    sensors    cells    metal    varied    subsequent    modular    single    recognition    consequently    conjunction    place    imaging    folded    adhesion    receptor    immune    bonding    exceptional    synthesize    consists   

Project "RAMSES" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.cnrs.fr/aquitaine/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 185˙076.00

Map

 Project objective

Carbohydrate recognition is fundamental in varied biological processes such as cellular differentiation, cell–cell interactions, immune defence and inflammatory response; consequently it plays key roles in tumour growth and metastasis, adhesion of viruses and bacteria to host cells and in immune and inflammatory disorders. It is well established that carbohydrate-binding molecules will have a strong impact on the development of new diagnostic and imaging methods and give rise to new opportunities for drug discovery. However the ab initio design of synthetic receptors for monosaccharides still remains an elusive objective, in particular if recognition is to take place in highly competitive polar media. This project aims to rationally design and synthesize single helically folded aromatic oligoamide capsules containing metal ions in order to achieve high affinity and selectivity for monosaccharides in polar media and to further develop them into functional fluorescent sensors. By introducing metal ions into foldamer frameworks a highly innovative class of receptors will be created which are expected to have exceptional binding abilities in polar media. The devised strategy consists in an iterative design process that exploits the modular structure of folded synthetic oligomer sequences in conjunction with structural characterization to inform subsequent refinements. Starting with a slightly larger than needed cavity possessing first-principles design that takes into account features such as size, shape and hydrogen bonding ability, the cavity size can iteratively be reduced while increasing shape complementarity with the substrate. With this evolutionary process the sequence will quickly converge towards a highly selective receptor for the target, which after replacement of key building blocks by fluorescent analogues, will be converted into a highly selective sensor.

 Publications

year authors and title journal last update
List of publications.
2017 Pedro Mateus, Barbara Wicher, Yann Ferrand, Ivan Huc
Alkali and alkaline earth metal ion binding by a foldamer capsule: selective recognition of magnesium hydrate
published pages: 9300-9303, ISSN: 1359-7345, DOI: 10.1039/C7CC05422J
Chemical Communications 53/67 2019-06-13
2018 Pedro Mateus, Barbara Wicher, Yann Ferrand, Ivan Huc
Carbohydrate binding through first- and second-sphere coordination within aromatic oligoamide metallofoldamers
published pages: 5078-5081, ISSN: 1359-7345, DOI: 10.1039/C8CC02360C
Chemical Communications 54/40 2019-06-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "RAMSES" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "RAMSES" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MBL-Fermions (2020)

Probing many-body localization dynamics using ultracold fermions in an optical lattice

Read More  

MathematicsAnalogies (2019)

Mathematics Analogies

Read More  

Self-EsteemProcesses (2020)

A self-esteem process framework of the transition to work

Read More