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RAMSES SIGNED

Aryl amide metallofoldamersas selective saccharide sensors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 RAMSES project word cloud

Explore the words cloud of the RAMSES project. It provides you a very rough idea of what is the project "RAMSES" about.

strategy    drug    replacement    oligoamide    imaging    devised    sequence    larger    ab    iteratively    refinements    created    give    metal    size    principles    host    slightly    carbohydrate    cellular    structural    functional    selective    aromatic    complementarity    bacteria    oligomer    characterization    consequently    helically    analogues    introducing    consists    monosaccharides    possessing    starting    cavity    viruses    hydrogen    converted    receptors    recognition    frameworks    rationally    innovative    takes    initio    sensors    fundamental    molecules    sequences    exploits    disorders    sensor    synthesize    diagnostic    defence    tumour    blocks    affinity    single    evolutionary    immune    ions    binding    place    substrate    first    synthetic    polar    media    biological    foldamer    inflammatory    adhesion    shape    converge    iterative    interactions    containing    roles    varied    discovery    metastasis    conjunction    competitive    exceptional    fluorescent    folded    inform    elusive    differentiation    cells    structure    class    receptor    subsequent    cell    bonding    capsules    building    selectivity    modular    plays   

Project "RAMSES" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.cnrs.fr/aquitaine/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 185˙076.00

Map

 Project objective

Carbohydrate recognition is fundamental in varied biological processes such as cellular differentiation, cell–cell interactions, immune defence and inflammatory response; consequently it plays key roles in tumour growth and metastasis, adhesion of viruses and bacteria to host cells and in immune and inflammatory disorders. It is well established that carbohydrate-binding molecules will have a strong impact on the development of new diagnostic and imaging methods and give rise to new opportunities for drug discovery. However the ab initio design of synthetic receptors for monosaccharides still remains an elusive objective, in particular if recognition is to take place in highly competitive polar media. This project aims to rationally design and synthesize single helically folded aromatic oligoamide capsules containing metal ions in order to achieve high affinity and selectivity for monosaccharides in polar media and to further develop them into functional fluorescent sensors. By introducing metal ions into foldamer frameworks a highly innovative class of receptors will be created which are expected to have exceptional binding abilities in polar media. The devised strategy consists in an iterative design process that exploits the modular structure of folded synthetic oligomer sequences in conjunction with structural characterization to inform subsequent refinements. Starting with a slightly larger than needed cavity possessing first-principles design that takes into account features such as size, shape and hydrogen bonding ability, the cavity size can iteratively be reduced while increasing shape complementarity with the substrate. With this evolutionary process the sequence will quickly converge towards a highly selective receptor for the target, which after replacement of key building blocks by fluorescent analogues, will be converted into a highly selective sensor.

 Publications

year authors and title journal last update
List of publications.
2017 Pedro Mateus, Barbara Wicher, Yann Ferrand, Ivan Huc
Alkali and alkaline earth metal ion binding by a foldamer capsule: selective recognition of magnesium hydrate
published pages: 9300-9303, ISSN: 1359-7345, DOI: 10.1039/C7CC05422J
Chemical Communications 53/67 2019-06-13
2018 Pedro Mateus, Barbara Wicher, Yann Ferrand, Ivan Huc
Carbohydrate binding through first- and second-sphere coordination within aromatic oligoamide metallofoldamers
published pages: 5078-5081, ISSN: 1359-7345, DOI: 10.1039/C8CC02360C
Chemical Communications 54/40 2019-06-13

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