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RAMSES SIGNED

Aryl amide metallofoldamersas selective saccharide sensors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 RAMSES project word cloud

Explore the words cloud of the RAMSES project. It provides you a very rough idea of what is the project "RAMSES" about.

building    exceptional    receptor    cells    sensors    refinements    converted    folded    receptors    sequences    substrate    synthetic    helically    disorders    inflammatory    differentiation    converge    size    interactions    principles    bonding    strategy    subsequent    slightly    innovative    sequence    cellular    metal    fundamental    binding    capsules    host    exploits    iteratively    consequently    modular    affinity    aromatic    drug    inform    plays    synthesize    consists    biological    molecules    structure    discovery    possessing    devised    selectivity    ab    conjunction    fluorescent    replacement    shape    introducing    place    structural    evolutionary    created    adhesion    imaging    ions    give    varied    blocks    viruses    diagnostic    larger    polar    oligoamide    cell    selective    tumour    competitive    carbohydrate    containing    starting    analogues    metastasis    characterization    frameworks    sensor    immune    complementarity    foldamer    rationally    roles    iterative    media    single    initio    elusive    hydrogen    functional    cavity    takes    first    class    recognition    monosaccharides    oligomer    bacteria    defence   

Project "RAMSES" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.cnrs.fr/aquitaine/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 185˙076.00

Map

 Project objective

Carbohydrate recognition is fundamental in varied biological processes such as cellular differentiation, cell–cell interactions, immune defence and inflammatory response; consequently it plays key roles in tumour growth and metastasis, adhesion of viruses and bacteria to host cells and in immune and inflammatory disorders. It is well established that carbohydrate-binding molecules will have a strong impact on the development of new diagnostic and imaging methods and give rise to new opportunities for drug discovery. However the ab initio design of synthetic receptors for monosaccharides still remains an elusive objective, in particular if recognition is to take place in highly competitive polar media. This project aims to rationally design and synthesize single helically folded aromatic oligoamide capsules containing metal ions in order to achieve high affinity and selectivity for monosaccharides in polar media and to further develop them into functional fluorescent sensors. By introducing metal ions into foldamer frameworks a highly innovative class of receptors will be created which are expected to have exceptional binding abilities in polar media. The devised strategy consists in an iterative design process that exploits the modular structure of folded synthetic oligomer sequences in conjunction with structural characterization to inform subsequent refinements. Starting with a slightly larger than needed cavity possessing first-principles design that takes into account features such as size, shape and hydrogen bonding ability, the cavity size can iteratively be reduced while increasing shape complementarity with the substrate. With this evolutionary process the sequence will quickly converge towards a highly selective receptor for the target, which after replacement of key building blocks by fluorescent analogues, will be converted into a highly selective sensor.

 Publications

year authors and title journal last update
List of publications.
2017 Pedro Mateus, Barbara Wicher, Yann Ferrand, Ivan Huc
Alkali and alkaline earth metal ion binding by a foldamer capsule: selective recognition of magnesium hydrate
published pages: 9300-9303, ISSN: 1359-7345, DOI: 10.1039/C7CC05422J
Chemical Communications 53/67 2019-06-13
2018 Pedro Mateus, Barbara Wicher, Yann Ferrand, Ivan Huc
Carbohydrate binding through first- and second-sphere coordination within aromatic oligoamide metallofoldamers
published pages: 5078-5081, ISSN: 1359-7345, DOI: 10.1039/C8CC02360C
Chemical Communications 54/40 2019-06-13

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