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GolgiBiosSys SIGNED

Identification and characterisation of plant Golgi biosynthetic multiprotein systems

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 GolgiBiosSys project word cloud

Explore the words cloud of the GolgiBiosSys project. It provides you a very rough idea of what is the project "GolgiBiosSys" about.

apparatus    proteome    conjunction    measured    myself    biomaterial    validated    data    secondly    lipid    organisation    gain    experimental    assignment    deepen    renewable    relevance    industries    immunoprecipitation    bioenergy    amount    arrangement    expertise    skills    action    knockout    technique    interaction    accomplishment    recalcitrant    little    abundant    pivotal    secretion    enzymes    leadership    performs    stoichiometries    complexes    proteomic    docking    biochemical    auxiliary    thought    multiprotein    cooperative    performed    sub    food    composition    localisation    functional    precise    throughput    presented    cell    lines    fuel    least    biosphere    golgi    fibre    membrane    carbohydrate    independent    biosynthesis    molecular    carbon    material    biosynthetic    academic    insights    map    glycosylation    protein    firstly    polysaccharides    interactions    thirdly    organic    researcher    humanity    proteins    model    separation    yield    organelle    orchestrated    governed    quantitative    functions    earth    organisational    structures   

Project "GolgiBiosSys" data sheet

The following table provides information about the project.

Coordinator		 EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 187˙419.00

Map

 Project objective

The Golgi apparatus is a system of organised membrane structures that performs pivotal cell functions: biosynthesis and secretion of polysaccharides, protein and lipid glycosylation. The relevance of this organelle is measured by the amount of biomaterial produced by its activity. The highly abundant polysaccharides account for at least a third of all renewable organic carbon on Earth and are of great importance to the biosphere and to humanity, providing food, fibre and fuel. The functionality of the Golgi is thought to be governed by molecular organisational features, as the precise arrangement of its membrane proteins. Each of the numerous biosynthetic pathways performed in the Golgi requires the cooperative and orchestrated action and interaction of several different enzymes and auxiliary proteins. Currently very little is known about the composition and sub-Golgi localisation of such multiprotein systems. Firstly, a comprehensive insight into the interaction map of the Golgi proteome is needed. I propose to develop and apply a technique that will allow high-throughput assignment of membrane protein interactions, and identify stoichiometries. An experimental design is presented based on separation of membrane protein complexes in conjunction with state of the art quantitative proteomic approaches. Secondly, the results will be validated on selected multiprotein systems by immunoprecipitation and functional biochemical studies on knockout lines. Thirdly, the data will be used to model the interactions by protein-protein docking. The accomplishment of this project will provide new insights into the organisation and activity of the biosynthetic systems. Such insight is of great value to the production of specific polysaccharides, tailored to yield less recalcitrant material for the bioenergy and carbohydrate industries. Through this work I aim to deepen my academic expertise, gain technical and leadership skills and to establish myself as an independent researcher.

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The information about "GOLGIBIOSSYS" are provided by the European Opendata Portal: CORDIS opendata.

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