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GolgiBiosSys SIGNED

Identification and characterisation of plant Golgi biosynthetic multiprotein systems

Total Cost €

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EC-Contrib. €

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Partnership

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 GolgiBiosSys project word cloud

Explore the words cloud of the GolgiBiosSys project. It provides you a very rough idea of what is the project "GolgiBiosSys" about.

fibre    glycosylation    complexes    secondly    food    gain    organisational    skills    independent    organisation    proteins    docking    relevance    enzymes    performed    composition    separation    proteomic    organelle    multiprotein    molecular    recalcitrant    interaction    measured    quantitative    biosphere    throughput    material    carbon    academic    renewable    conjunction    organic    golgi    experimental    abundant    pivotal    knockout    membrane    presented    industries    functions    structures    protein    immunoprecipitation    stoichiometries    data    governed    deepen    biomaterial    interactions    researcher    accomplishment    little    orchestrated    auxiliary    leadership    map    carbohydrate    lines    amount    apparatus    proteome    model    sub    validated    firstly    secretion    yield    action    assignment    thought    myself    arrangement    humanity    expertise    polysaccharides    biochemical    localisation    bioenergy    cell    thirdly    biosynthetic    biosynthesis    cooperative    functional    precise    insights    fuel    lipid    least    performs    earth    technique   

Project "GolgiBiosSys" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 187˙419.00

Map

 Project objective

The Golgi apparatus is a system of organised membrane structures that performs pivotal cell functions: biosynthesis and secretion of polysaccharides, protein and lipid glycosylation. The relevance of this organelle is measured by the amount of biomaterial produced by its activity. The highly abundant polysaccharides account for at least a third of all renewable organic carbon on Earth and are of great importance to the biosphere and to humanity, providing food, fibre and fuel. The functionality of the Golgi is thought to be governed by molecular organisational features, as the precise arrangement of its membrane proteins. Each of the numerous biosynthetic pathways performed in the Golgi requires the cooperative and orchestrated action and interaction of several different enzymes and auxiliary proteins. Currently very little is known about the composition and sub-Golgi localisation of such multiprotein systems. Firstly, a comprehensive insight into the interaction map of the Golgi proteome is needed. I propose to develop and apply a technique that will allow high-throughput assignment of membrane protein interactions, and identify stoichiometries. An experimental design is presented based on separation of membrane protein complexes in conjunction with state of the art quantitative proteomic approaches. Secondly, the results will be validated on selected multiprotein systems by immunoprecipitation and functional biochemical studies on knockout lines. Thirdly, the data will be used to model the interactions by protein-protein docking. The accomplishment of this project will provide new insights into the organisation and activity of the biosynthetic systems. Such insight is of great value to the production of specific polysaccharides, tailored to yield less recalcitrant material for the bioenergy and carbohydrate industries. Through this work I aim to deepen my academic expertise, gain technical and leadership skills and to establish myself as an independent researcher.

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The information about "GOLGIBIOSSYS" are provided by the European Opendata Portal: CORDIS opendata.

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