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STRATIFY SIGNED

Diagnostic autoantibody assay to stratify bone marrow failure diseases

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

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 STRATIFY project word cloud

Explore the words cloud of the STRATIFY project. It provides you a very rough idea of what is the project "STRATIFY" about.

producing    cog    potentially    stem    group    accuracy    companion    healthcare    serious    erc    options    believe    lack    validity    tests    savings    thousands    lies    threatening    carry    red    reveal    patients    inappropriate    screening    rare    constitute    genetic    pharma    bmfs    therapy    poc    bone    samples    therapies    syndromes    clinicians    difficulties    simultaneous    commercialisation    follows    innovation    haematological    companies    anaemia    background    subset    destroyed    clinical    takes    leukopenia    machines    suggesting    preliminary    aplastic    life    discovery    hundreds    diagnosis    introducing    inherently    pathology    proper    protein    reagent    actions    acquired    misdiagnosis    diseases    unexplained    autoantibody    vast    laboratory    cells    heterogenous    underlying    confirming    kit    pathogenesis    marrow    inexpensive    lives    personalised    defective    serology    positivity    exclusion    aa    white    time    elderly    diagnostic    made    manifest    blood   

Project "STRATIFY" data sheet

The following table provides information about the project.

Coordinator
HELSINGIN YLIOPISTO 

Organization address
address: YLIOPISTONKATU 3
city: HELSINGIN YLIOPISTO
postcode: 14
website: www.helsinki.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) coordinator 150˙000.00

Map

 Project objective

Bone marrow failure syndromes (BMFS) such as aplastic anaemia (AA) are a heterogenous group of rare diseases that manifest as loss of red and white blood cells. In these potentially life-threatening diseases, blood producing stem cells may be inherently defective or become destroyed due to acquired cause. Diagnostic difficulties of BMFS constitute a significant clinical problem as the diagnosis takes long, and misdiagnosis may lead to inappropriate management with serious side effects.

In our ERC-CoG project we made an exciting discovery and identified a novel autoantibody in AA patients’ blood samples. Autoantibody positivity defined a distinct group of patients with similar genetic background suggesting common pathogenesis. Our preliminary results show that the autoantibody analysis has great potential to reveal cases of AA and define a subset of other BMFS patients with similar underlying pathology that currently lack proper diagnosis. Furthermore, vast commercialisation potential lies in introducing it as an exclusion laboratory test in patients with unexplained anaemia or leukopenia (common problems in elderly). The improved diagnostic accuracy and the targeted personalised therapy that follows has the potential to impact the lives of hundreds of thousands of patients over time and bring simultaneous healthcare savings. Further, understanding of the role of target protein of the autoantibody in bone marrow failure may lead to targeted therapies in the future.

We believe that the test can be developed as an inexpensive reagent kit to be used in serology machines for autoantibody screening. In order to improve the commercialisation potential, we will carry out 1) Technology PoC for confirming the approach validity, and 2) Pre-commercialisation actions for evaluating the best commercialisation options for bringing the innovation to clinicians managing haematological patients and for pharma companies as companion diagnostic tests together with their therapies.

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The information about "STRATIFY" are provided by the European Opendata Portal: CORDIS opendata.

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