ADHDLightUp
Circuit-based deconstruction of Attention deficit and Hyperactive disorder with optogenetic Light control
Total Cost €
0EC-Contrib. €
0Partnership
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Project "ADHDLightUp" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITE LIBRE DE BRUXELLES
Organization address contact info |
| Coordinator Country | Belgium [BE] |
| Total cost | 172˙800 € |
| EC max contribution | 172˙800 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2015 |
| Funding Scheme | MSCA-IF-EF-RI |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-10-01 to 2018-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITE LIBRE DE BRUXELLES | BE (BRUXELLES) | coordinator | 172˙800.00 |
Map
Project objective
Attention-deficit/hyperactivity disorder (ADHD) like many other mental illnesses probably results from a combination of genetic and developmental factors pointing at abnormalities in brain monoamines (MA). Imaging studies in ADHD patients also indicate deficits in activity of various brain regions including the prefrontal cortex (PFC) and basal ganglia (BG). The mechanisms by which PFC and BG dysfunctions are triggered, and can be corrected with MA-based treatment are unknown. Although there is a consistent frontal hypoactivity detected in ADHD, some variations are seen amongst executive processes including attention or impulse control, in which MA have specific functions. Besides, the limited spatial resolution of brain imaging does not allow to detect certain subregions or discriminate neuronal subpopulations. In order to identify brain network impairments in ADHD, we need models to further dissect frontal dysfunctions looking at MA signaling, cell excitability and behavioral correlates of activity in identified neurons. The goal of this project is to untangle brain circuits involved in a novel mouse model of ADHD, which fulfills the major criteria reflecting human condition, showing specific BG dysfunctions and differential MA involvement. Innovative approaches have been chosen to accomplish this challenge that include transgenesis, opto- and pharmaco-genetics, and in vivo measurement of neuronal activity in translational behavioral tasks assessing attention and impulsivity. Importantly, while the most common medication using psychotimulants has proven the best efficiency, it has also been shown to affect children growth and their adult mental health highlighting the urge for alternatives. We believe that our model and multidisciplinary methodology provide new insights in ADHD ætiology and allow to develop new concepts and/or targets for therapeutic alternatives further based on the manipulation of neurons activity to reverse or attenuate ADHD symptoms.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Marine Chazalon, Sylvie Dumas, Jean-François Bernard, Iman Sahly, François Tronche, Alban de Kerchove d’Exaerde, Michel Hamon, Joëlle Adrien, Véronique Fabre, Patricia Bonnavion The GABAergic Gudden\'s dorsal tegmental nucleus: A new relay for serotonergic regulation of sleep-wake behavior in the mouse published pages: 315-330, ISSN: 0028-3908, DOI: 10.1016/j.neuropharm.2018.06.014 |
Neuropharmacology 138 | 2019-10-08 |
| 2017 |
Akie Fujita, Patricia Bonnavion, Miryam H. Wilson, Laura E. Mickelsen, Julien Bloit, Luis de Lecea, Alexander C. Jackson Hypothalamic Tuberomammillary Nucleus Neurons: Electrophysiological Diversity and Essential Role in Arousal Stability published pages: 9574-9592, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.0580-17.2017 |
The Journal of Neuroscience 37/39 | 2019-10-08 |
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