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ADHDLightUp

Circuit-based deconstruction of Attention deficit and Hyperactive disorder with optogenetic Light control

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ADHDLightUp project word cloud

Explore the words cloud of the ADHDLightUp project. It provides you a very rough idea of what is the project "ADHDLightUp" about.

limited    executive    functions    involvement    multidisciplinary    human    believe    imaging    urge    impulsivity    developmental    pfc    attenuate    frontal    behavioral    opto    attention    cell    indicate    pointing    reflecting    signaling    triggered    criteria    monoamines    patients    efficiency    brain    besides    resolution    highlighting    subregions    assessing    alternatives    cortex    unknown    children    certain    basal    shown    showing    reverse    symptoms    bg    variations    mental    hypoactivity    circuits    proven    deficits    detected    translational    ganglia    models    tiology    mechanisms    transgenesis    discriminate    combination    untangle    mouse    adhd    hyperactivity    illnesses    aelig    excitability    adult    dysfunctions    corrected    pharmaco    model    insights    impairments    innovative    fulfills    chosen    vivo    network    neurons    probably    regions    genetics    consistent    dissect    treatment    genetic    spatial    correlates    therapeutic    ma    medication    deficit    impulse    abnormalities    differential    prefrontal    manipulation    detect    methodology    disorder    neuronal    subpopulations    amongst    health    psychotimulants   

Project "ADHDLightUp" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LIBRE DE BRUXELLES 

Organization address
address: AVENUE FRANKLIN ROOSEVELT 50
city: BRUXELLES
postcode: 1050
website: www.ulb.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 172˙800 €
 EC max contribution 172˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2018-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) coordinator 172˙800.00

Map

 Project objective

Attention-deficit/hyperactivity disorder (ADHD) like many other mental illnesses probably results from a combination of genetic and developmental factors pointing at abnormalities in brain monoamines (MA). Imaging studies in ADHD patients also indicate deficits in activity of various brain regions including the prefrontal cortex (PFC) and basal ganglia (BG). The mechanisms by which PFC and BG dysfunctions are triggered, and can be corrected with MA-based treatment are unknown. Although there is a consistent frontal hypoactivity detected in ADHD, some variations are seen amongst executive processes including attention or impulse control, in which MA have specific functions. Besides, the limited spatial resolution of brain imaging does not allow to detect certain subregions or discriminate neuronal subpopulations. In order to identify brain network impairments in ADHD, we need models to further dissect frontal dysfunctions looking at MA signaling, cell excitability and behavioral correlates of activity in identified neurons. The goal of this project is to untangle brain circuits involved in a novel mouse model of ADHD, which fulfills the major criteria reflecting human condition, showing specific BG dysfunctions and differential MA involvement. Innovative approaches have been chosen to accomplish this challenge that include transgenesis, opto- and pharmaco-genetics, and in vivo measurement of neuronal activity in translational behavioral tasks assessing attention and impulsivity. Importantly, while the most common medication using psychotimulants has proven the best efficiency, it has also been shown to affect children growth and their adult mental health highlighting the urge for alternatives. We believe that our model and multidisciplinary methodology provide new insights in ADHD ætiology and allow to develop new concepts and/or targets for therapeutic alternatives further based on the manipulation of neurons activity to reverse or attenuate ADHD symptoms.

 Publications

year authors and title journal last update
List of publications.
2018 Marine Chazalon, Sylvie Dumas, Jean-François Bernard, Iman Sahly, François Tronche, Alban de Kerchove d’Exaerde, Michel Hamon, Joëlle Adrien, Véronique Fabre, Patricia Bonnavion
The GABAergic Gudden\'s dorsal tegmental nucleus: A new relay for serotonergic regulation of sleep-wake behavior in the mouse
published pages: 315-330, ISSN: 0028-3908, DOI: 10.1016/j.neuropharm.2018.06.014
Neuropharmacology 138 2019-10-08
2017 Akie Fujita, Patricia Bonnavion, Miryam H. Wilson, Laura E. Mickelsen, Julien Bloit, Luis de Lecea, Alexander C. Jackson
Hypothalamic Tuberomammillary Nucleus Neurons: Electrophysiological Diversity and Essential Role in Arousal Stability
published pages: 9574-9592, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.0580-17.2017
The Journal of Neuroscience 37/39 2019-10-08

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