EU H2020 Project "ADHDLIGHTUP (Circuit-based deconstruction of Attention deficit and Hyperactive disorder..)": description, partecipants, costs and EC-fundings

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ADHDLightUp project word cloud

Explore the words cloud of the ADHDLightUp project. It provides you a very rough idea of what is the project "ADHDLightUp" about.

reflecting corrected models manipulation differential attenuate developmental believe limited alternatives subpopulations spatial deficits hypoactivity genetic medication transgenesis impulse urge mouse functions criteria circuits children involvement imaging excitability therapeutic tiology aelig bg neuronal chosen indicate genetics resolution proven highlighting efficiency mechanisms vivo methodology executive impairments amongst opto discriminate monoamines illnesses treatment pointing symptoms brain probably certain hyperactivity innovative abnormalities neurons adult consistent variations ganglia cell psychotimulants human mental deficit besides adhd unknown pfc disorder detected shown translational multidisciplinary subregions fulfills dysfunctions behavioral patients impulsivity basal cortex combination attention ma correlates dissect reverse prefrontal signaling assessing health triggered pharmaco insights frontal network untangle detect showing model regions

Project "ADHDLightUp" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE LIBRE DE BRUXELLES Organization address address: AVENUE FRANKLIN ROOSEVELT 50 city: BRUXELLES postcode: 1050 website: www.ulb.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Total cost	172˙800 €
EC max contribution	172˙800 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-RI
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2018-09-30

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE LIBRE DE BRUXELLES	BE (BRUXELLES)	coordinator	172˙800.00

UNIVERSITE LIBRE DE BRUXELLES

BE (BRUXELLES)

coordinator

172˙800.00

Project objective

Attention-deficit/hyperactivity disorder (ADHD) like many other mental illnesses probably results from a combination of genetic and developmental factors pointing at abnormalities in brain monoamines (MA). Imaging studies in ADHD patients also indicate deficits in activity of various brain regions including the prefrontal cortex (PFC) and basal ganglia (BG). The mechanisms by which PFC and BG dysfunctions are triggered, and can be corrected with MA-based treatment are unknown. Although there is a consistent frontal hypoactivity detected in ADHD, some variations are seen amongst executive processes including attention or impulse control, in which MA have specific functions. Besides, the limited spatial resolution of brain imaging does not allow to detect certain subregions or discriminate neuronal subpopulations. In order to identify brain network impairments in ADHD, we need models to further dissect frontal dysfunctions looking at MA signaling, cell excitability and behavioral correlates of activity in identified neurons. The goal of this project is to untangle brain circuits involved in a novel mouse model of ADHD, which fulfills the major criteria reflecting human condition, showing specific BG dysfunctions and differential MA involvement. Innovative approaches have been chosen to accomplish this challenge that include transgenesis, opto- and pharmaco-genetics, and in vivo measurement of neuronal activity in translational behavioral tasks assessing attention and impulsivity. Importantly, while the most common medication using psychotimulants has proven the best efficiency, it has also been shown to affect children growth and their adult mental health highlighting the urge for alternatives. We believe that our model and multidisciplinary methodology provide new insights in ADHD ætiology and allow to develop new concepts and/or targets for therapeutic alternatives further based on the manipulation of neurons activity to reverse or attenuate ADHD symptoms.

Publications

List of publications.
year	authors and title	journal	last update
2018	Marine Chazalon, Sylvie Dumas, Jean-FranÃ§ois Bernard, Iman Sahly, FranÃ§ois Tronche, Alban de Kerchove dâ€™Exaerde, Michel Hamon, JoÃ«lle Adrien, VÃ©ronique Fabre, Patricia Bonnavion The GABAergic Gudden\'s dorsal tegmental nucleus: A new relay for serotonergic regulation of sleep-wake behavior in the mouse published pages: 315-330, ISSN: 0028-3908, DOI: 10.1016/j.neuropharm.2018.06.014	Neuropharmacology 138	2019-10-08
2017	Akie Fujita, Patricia Bonnavion, Miryam H. Wilson, Laura E. Mickelsen, Julien Bloit, Luis de Lecea, Alexander C. Jackson Hypothalamic Tuberomammillary Nucleus Neurons: Electrophysiological Diversity and Essential Role in Arousal Stability published pages: 9574-9592, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.0580-17.2017	The Journal of Neuroscience 37/39	2019-10-08

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