Opendata, web and dolomites

ADHDLightUp

Circuit-based deconstruction of Attention deficit and Hyperactive disorder with optogenetic Light control

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ADHDLightUp project word cloud

Explore the words cloud of the ADHDLightUp project. It provides you a very rough idea of what is the project "ADHDLightUp" about.

bg    indicate    mental    symptoms    neuronal    pointing    spatial    adhd    adult    deficits    network    cell    urge    subregions    hyperactivity    opto    patients    variations    subpopulations    differential    shown    imaging    reverse    unknown    probably    correlates    ma    psychotimulants    showing    tiology    impulse    vivo    amongst    circuits    neurons    detect    disorder    reflecting    corrected    developmental    therapeutic    regions    impairments    methodology    illnesses    believe    multidisciplinary    criteria    assessing    alternatives    abnormalities    highlighting    besides    executive    fulfills    aelig    signaling    translational    resolution    consistent    transgenesis    children    limited    excitability    untangle    frontal    functions    pharmaco    health    monoamines    pfc    hypoactivity    genetics    proven    model    brain    involvement    models    insights    attenuate    dissect    mechanisms    chosen    cortex    manipulation    deficit    innovative    genetic    discriminate    triggered    impulsivity    efficiency    detected    basal    attention    dysfunctions    prefrontal    mouse    ganglia    human    treatment    medication    combination    behavioral    certain   

Project "ADHDLightUp" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LIBRE DE BRUXELLES 

Organization address
address: AVENUE FRANKLIN ROOSEVELT 50
city: BRUXELLES
postcode: 1050
website: www.ulb.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 172˙800 €
 EC max contribution 172˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2018-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) coordinator 172˙800.00

Map

 Project objective

Attention-deficit/hyperactivity disorder (ADHD) like many other mental illnesses probably results from a combination of genetic and developmental factors pointing at abnormalities in brain monoamines (MA). Imaging studies in ADHD patients also indicate deficits in activity of various brain regions including the prefrontal cortex (PFC) and basal ganglia (BG). The mechanisms by which PFC and BG dysfunctions are triggered, and can be corrected with MA-based treatment are unknown. Although there is a consistent frontal hypoactivity detected in ADHD, some variations are seen amongst executive processes including attention or impulse control, in which MA have specific functions. Besides, the limited spatial resolution of brain imaging does not allow to detect certain subregions or discriminate neuronal subpopulations. In order to identify brain network impairments in ADHD, we need models to further dissect frontal dysfunctions looking at MA signaling, cell excitability and behavioral correlates of activity in identified neurons. The goal of this project is to untangle brain circuits involved in a novel mouse model of ADHD, which fulfills the major criteria reflecting human condition, showing specific BG dysfunctions and differential MA involvement. Innovative approaches have been chosen to accomplish this challenge that include transgenesis, opto- and pharmaco-genetics, and in vivo measurement of neuronal activity in translational behavioral tasks assessing attention and impulsivity. Importantly, while the most common medication using psychotimulants has proven the best efficiency, it has also been shown to affect children growth and their adult mental health highlighting the urge for alternatives. We believe that our model and multidisciplinary methodology provide new insights in ADHD ætiology and allow to develop new concepts and/or targets for therapeutic alternatives further based on the manipulation of neurons activity to reverse or attenuate ADHD symptoms.

 Publications

year authors and title journal last update
List of publications.
2018 Marine Chazalon, Sylvie Dumas, Jean-François Bernard, Iman Sahly, François Tronche, Alban de Kerchove d’Exaerde, Michel Hamon, Joëlle Adrien, Véronique Fabre, Patricia Bonnavion
The GABAergic Gudden\'s dorsal tegmental nucleus: A new relay for serotonergic regulation of sleep-wake behavior in the mouse
published pages: 315-330, ISSN: 0028-3908, DOI: 10.1016/j.neuropharm.2018.06.014
Neuropharmacology 138 2019-10-08
2017 Akie Fujita, Patricia Bonnavion, Miryam H. Wilson, Laura E. Mickelsen, Julien Bloit, Luis de Lecea, Alexander C. Jackson
Hypothalamic Tuberomammillary Nucleus Neurons: Electrophysiological Diversity and Essential Role in Arousal Stability
published pages: 9574-9592, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.0580-17.2017
The Journal of Neuroscience 37/39 2019-10-08

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ADHDLIGHTUP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ADHDLIGHTUP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MultiSeaSpace (2019)

Developing a unified spatial modelling strategy that accounts for interactions between species at different marine trophic levels, and different types of survey data.

Read More  

LIGHTMATT-EXPLORER (2019)

Experimental determination of the paraxial-vectorial limit of light-matter interactions

Read More  

POSPORI (2019)

Polymer Optical Sensors for Prolonged Overseeing the Robustness of civil Infrastructures

Read More