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PrinTendon

Development of a tendon/ligament substitute through bioprinting

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PrinTendon project word cloud

Explore the words cloud of the PrinTendon project. It provides you a very rough idea of what is the project "PrinTendon" about.

bright    induce    differentiation    reproducibility    constructs    mimicking    advantage    designed    vivo    shown    strategies    innovative    unexplored    translation    harvested    restricted    bioprinting    substitute    hascs    collagen    allografts    replacement    assay    fibre    inclusion    combines    option    human    capacity    live    substitutes    living    tissue    magnetic    mechanical    forces    3d    accelerated    source    prostheses    engineering    satisfy    immune    stimulation    autografts    limitations    biological    replicate    automation    assure    create    nanoparticles    cells    self    artificial    technologies    structure    injury    printers    function    people    adipose    clinical    viability    expanded    native    life    repair    tendon    alignment    natural    cell    date    bioprinted    ligament    autologous    tenogenic    regenerated    dramatically    hybrid    limited    silk    acceptable    fast    clinics    fibroin    easily    patient    quality    scaffolds    mechano    adverse    prior    tested    stem   

Project "PrinTendon" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE DO MINHO 

Organization address
address: LARGO DO PACO
city: BRAGA
postcode: 4704 553
website: www.uminho.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website https://3bs.uminho.pt/projects
 Total cost 160˙635 €
 EC max contribution 160˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-15   to  2018-09-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DO MINHO PT (BRAGA) coordinator 160˙635.00

Map

 Project objective

Tendon/ligament (T/L) injury is a common clinical problem that can dramatically affect a patient’s quality of life. The native structure of T/L makes them have limited ability to self-repair. Current approaches for T/L substitutes include autografts, allografts and artificial prostheses although their mechanical limitations and/or the induced adverse immune responses have restricted their use, which have accelerated the development of tissue engineering strategies. However, to the date, no clinical long-standing acceptable T/L substitute is available. For this reason, the project’s overall objective is developing an innovative T/L replacement that results in a fully regenerated living tissue, mimicking the natural structure and function and with long-term viability. The unexplored approach that we want take advantage of is through 3D bioprinting and mechano-magnetic stimulation. The use of bioprinting technologies will allow to replicate the tissue structure and together with mechano-magnetic stimulation will induce cell and fibre alignment, that have been shown to induce tenogenic differentiation. Hybrid collagen-silk fibroin scaffolds will be designed and bioprinted to satisfy the mechanical and biological properties needed for T/L substitutes. Mechanical stimulation will be achieved by the inclusion of magnetic nanoparticles in the scaffolds and the use of magnetic forces. Tissue-like constructs will be tested for its mechanical properties and its capacity to induce tenogenic differentiation of human adipose derived stem cells (hASCs), prior to an in vivo assay. This proposal combines the use of bioprinting and magnetic nanoparticles in a bright and new option to create T/L substitutes. Taking into account that hASCs can be easily harvested and expanded from autologous source and that 3D printers have high reproducibility and automation, this approach will assure an easy and fast translation to clinics to improve people’s live.

 Publications

year authors and title journal last update
List of publications.
2018 Bárbara B. Mendes, Manuel Gómez-Florit, Pedro S. Babo, Rui M. Domingues, Rui L. Reis, Manuela E. Gomes
Blood derivatives awaken in regenerative medicine strategies to modulate wound healing
published pages: 376-393, ISSN: 0169-409X, DOI: 10.1016/j.addr.2017.12.018
Advanced Drug Delivery Reviews 129 2019-05-09
2018 Bárbara B. Mendes, Manuel Gómez-Florit, Ricardo A. Pires, Rui M. A. Domingues, Rui L. Reis, Manuela E. Gomes
Human-based fibrillar nanocomposite hydrogels as bioinstructive matrices to tune stem cell behavior
published pages: 17388-17401, ISSN: 2040-3364, DOI: 10.1039/c8nr04273j
Nanoscale 10/36 2019-05-29

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The information about "PRINTENDON" are provided by the European Opendata Portal: CORDIS opendata.

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