Opendata, web and dolomites

PrinTendon

Development of a tendon/ligament substitute through bioprinting

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PrinTendon project word cloud

Explore the words cloud of the PrinTendon project. It provides you a very rough idea of what is the project "PrinTendon" about.

silk    living    cell    stem    harvested    mechano    viability    acceptable    strategies    assay    injury    unexplored    replicate    adipose    expanded    repair    option    clinics    biological    advantage    life    regenerated    bioprinting    induce    3d    mechanical    magnetic    prior    alignment    easily    fibroin    clinical    autologous    patient    satisfy    tendon    combines    limitations    translation    tissue    bright    adverse    create    vivo    human    artificial    fibre    limited    live    source    replacement    structure    bioprinted    tested    substitutes    capacity    allografts    tenogenic    hybrid    technologies    printers    nanoparticles    reproducibility    quality    mimicking    native    designed    differentiation    shown    automation    function    substitute    immune    ligament    autografts    constructs    restricted    natural    inclusion    date    scaffolds    hascs    forces    innovative    collagen    stimulation    cells    people    engineering    self    prostheses    dramatically    assure    accelerated    fast   

Project "PrinTendon" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE DO MINHO 

Organization address
address: LARGO DO PACO
city: BRAGA
postcode: 4704 553
website: www.uminho.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website https://3bs.uminho.pt/projects
 Total cost 160˙635 €
 EC max contribution 160˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-15   to  2018-09-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DO MINHO PT (BRAGA) coordinator 160˙635.00

Map

 Project objective

Tendon/ligament (T/L) injury is a common clinical problem that can dramatically affect a patient’s quality of life. The native structure of T/L makes them have limited ability to self-repair. Current approaches for T/L substitutes include autografts, allografts and artificial prostheses although their mechanical limitations and/or the induced adverse immune responses have restricted their use, which have accelerated the development of tissue engineering strategies. However, to the date, no clinical long-standing acceptable T/L substitute is available. For this reason, the project’s overall objective is developing an innovative T/L replacement that results in a fully regenerated living tissue, mimicking the natural structure and function and with long-term viability. The unexplored approach that we want take advantage of is through 3D bioprinting and mechano-magnetic stimulation. The use of bioprinting technologies will allow to replicate the tissue structure and together with mechano-magnetic stimulation will induce cell and fibre alignment, that have been shown to induce tenogenic differentiation. Hybrid collagen-silk fibroin scaffolds will be designed and bioprinted to satisfy the mechanical and biological properties needed for T/L substitutes. Mechanical stimulation will be achieved by the inclusion of magnetic nanoparticles in the scaffolds and the use of magnetic forces. Tissue-like constructs will be tested for its mechanical properties and its capacity to induce tenogenic differentiation of human adipose derived stem cells (hASCs), prior to an in vivo assay. This proposal combines the use of bioprinting and magnetic nanoparticles in a bright and new option to create T/L substitutes. Taking into account that hASCs can be easily harvested and expanded from autologous source and that 3D printers have high reproducibility and automation, this approach will assure an easy and fast translation to clinics to improve people’s live.

 Publications

year authors and title journal last update
List of publications.
2018 Bárbara B. Mendes, Manuel Gómez-Florit, Pedro S. Babo, Rui M. Domingues, Rui L. Reis, Manuela E. Gomes
Blood derivatives awaken in regenerative medicine strategies to modulate wound healing
published pages: 376-393, ISSN: 0169-409X, DOI: 10.1016/j.addr.2017.12.018
Advanced Drug Delivery Reviews 129 2019-05-09
2018 Bárbara B. Mendes, Manuel Gómez-Florit, Ricardo A. Pires, Rui M. A. Domingues, Rui L. Reis, Manuela E. Gomes
Human-based fibrillar nanocomposite hydrogels as bioinstructive matrices to tune stem cell behavior
published pages: 17388-17401, ISSN: 2040-3364, DOI: 10.1039/c8nr04273j
Nanoscale 10/36 2019-05-29

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PRINTENDON" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PRINTENDON" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More  

AsymmFlow (2020)

Go with the continuous flow: Asymmetric Synthesis of Bioactive Alkaloids by Multistep Continuous-Flow Processes

Read More