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DIET-SEX-GENOMICS SIGNED

Linking genotype to phenotype - Role of diet on sex-specific reproduction

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "DIET-SEX-GENOMICS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: London
postcode: WC1E 6BT
website: http://www.ucl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.florenciacamus.com
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2018-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (London) coordinator 183˙454.00

Map

 Project objective

Males and females perform different reproductive roles and have adapted to these by evolving sometimes strikingly different phenotypes. A key means to observe and understand differences is to examine metabolism, with studies being able to link differences in diet composition to varying levels of phenotypes. In spite of the clear dimorphism observed across the animal kingdom, both sexes are locked into a struggle over adaptation, rooted in the fact that both sexes share an almost identical genome. Here, I propose to combine high-throughput phenotypic approaches (including quantitative genetic tools), with cutting-edge genome expression data to identify genes and genetic pathways that are involved in metabolic conflict. My first aim is to explore whether males and females differ in dietary preference using Drosophila melanogaster as a model organism. I will establish the extent to which genetic correlations between male and female food preferences constrain the evolution of optimal diet choice. Consequently, my second aim is to identify genes and/or genetic pathways that are responsible for differences in diet preference, and limit the dietary adaptation. Finally, I will use state-of-the-art genetic manipulations to enhance/suppress parts of the genetic pathways involved in metabolism, and will examine if these genetic modifications bring sex-specific consequences to the physiology of the organism. Understanding the genetic basis for sex differences in metabolism will aid to build complete understanding of the differences between males and females at the cellular level and provide insight into dietary and metabolic influences as well as aid human health research.

 Publications

year authors and title journal last update
List of publications.
2017 Max Reuter, M. Florencia Camus, Mark S. Hill, Filip Ruzicka, Kevin Fowler
Evolving Plastic Responses to External and Genetic Environments
published pages: 169-170, ISSN: 0168-9525, DOI: 10.1016/j.tig.2017.01.004
Trends in Genetics 33/3 2019-06-13
2018 M. Florencia Camus, Damian K. Dowling
Mitochondrial genetic effects on reproductive success: signatures of positive intrasexual, but negative intersexual pleiotropy
published pages: 20180187, ISSN: 0962-8452, DOI: 10.1098/rspb.2018.0187
Proceedings of the Royal Society B: Biological Sciences 285/1879 2019-06-13
2018 M. Florencia Camus, Chun-Cheng Huang, Max Reuter, Kevin Fowler
Dietary choices are influenced by genotype, mating status, and sex in Drosophila melanogaster
published pages: 5385-5393, ISSN: 2045-7758, DOI: 10.1002/ece3.4055
Ecology and Evolution 8/11 2019-06-13
2017 M. Florencia Camus, Jonci N. Wolff, Carla M. Sgrò, Damian K. Dowling
Experimental Support That Natural Selection Has Shaped the Latitudinal Distribution of Mitochondrial Haplotypes in Australian Drosophila melanogaster
published pages: 2600-2612, ISSN: 0737-4038, DOI: 10.1093/molbev/msx184
Molecular Biology and Evolution 34/10 2019-06-13
2017 Edward H. Morrow, M. Florencia Camus
Mitonuclear epistasis and mitochondrial disease
published pages: 119-122, ISSN: 1567-7249, DOI: 10.1016/j.mito.2017.06.001
Mitochondrion 35 2019-06-13

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