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NANOZ-ONIC SIGNED

Bio-inspired electrONIC NOSE interfacing olfactory electrical biosensors and carbon NANOtubes

Total Cost €

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EC-Contrib. €

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Partnership

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 NANOZ-ONIC project word cloud

Explore the words cloud of the NANOZ-ONIC project. It provides you a very rough idea of what is the project "NANOZ-ONIC" about.

diagnosis    sensitivity    electronic    neurodegeneration    single    device    painless    invasive    breath    quantitatively    care    channel    fusion    technologies    chemical    nanotubes    biosensors    library    interfaced    demonstrates    diabetes    asthma    walled    fibrosis    effect    iccrs    transduced    feasibility    multiplex    ideal    versatility    coupled    mainly    biological    detect    cancers    engineer    biomarker    poor    compound    coating    signal    receptors    specificity    fets    home    electrical    fet    recognize    point    recognition    diseases    mammalian    noses    gpcr    either    miniaturized    nanovesicles    nanometric    members    gpcrs    mimicked    simultaneously    iccr    monitoring    combinatorial    hindered    nanotube    patients    natural    swcnt    olfactory    protein    selectivity    volatile    carbon    innovative    receptor    medical    inspired    odours    transistors    detection    original    time    fast    created    integrating    biomarkers    diagnosing    generalisation    biosensor    containing    exhaled    cystic    ion    pathologies   

Project "NANOZ-ONIC" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙926˙870 €
 EC max contribution 1˙926˙870 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙434˙325.00
2    SEOUL NATIONAL UNIVERSITY KR (SEOUL) participant 492˙545.00

Map

 Project objective

The goal of this project is to develop an innovative biosensor for the non-invasive, painless and real-time detection of volatile biomarkers in the exhaled breath of patients. Volatile biomarkers have been identified for several diseases including cancers, diabetes, cystic fibrosis and neurodegeneration. A miniaturized system for fast and simple breath-analysis would not only improve the early detection of these pathologies but also enable point-of-care monitoring of patients either in medical institutions or at home. Different electronic noses are in development (or even in use for diagnosing asthma), however their generalisation in reliable medical diagnosis devices is mainly hindered by their poor versatility. The main challenge is to quantitatively and simultaneously detect several volatile biomarkers with high specificity and selectivity. The ideal technology would be one which mimicked the natural olfactory systems that recognize odours by combinatorial analysis of receptor responses. Inspired by this biological example, this project aims at integrating natural olfactory receptors into two state-of-the-art technologies: Ion Channel-Coupled Receptors (ICCRs) and single-walled Carbon NanoTube-Field Effect Transistors (swCNT-FETs). ICCRs are original biosensors created by fusion of G Protein Coupled Receptors (GPCRs) with an ion channel. The recognition of a chemical compound by the GPCR is transduced into an electrical signal by the ion channel. Mammalian olfactory receptors are GPCRs, and the objective of this 5-year project is to engineer an original library of olfactory ICCRs for multiplex detection of volatile biomarkers. To detect the electrical signal with very high sensitivity and at the nanometric scale, ICCRs will be interfaced with swCNT-FET transistors by coating the carbon nanotubes with ICCR-containing nanovesicles. The recent detection of a biomarker with an ICCR-swCNT-FET device by project members demonstrates the feasibility of this approach.

 Publications

year authors and title journal last update
List of publications.
2018 Viet Anh Pham Ba, Yoo Min Han, Youngtak Cho, Taewan Kim, Byung Yang Lee, Joo Sung Kim, Seunghun Hong
Modified Floating Electrode-Based Sensors for the Quantitative Monitoring of Drug Effects on Cytokine Levels Related with Inflammatory Bowel Diseases
published pages: 17100-17106, ISSN: 1944-8244, DOI: 10.1021/acsami.8b04287
ACS Applied Materials & Interfaces 10/20 2019-11-25
2019 Shashank Shekhar, Hyungwoo Lee, Duckhyung Cho, Myungjae Yang, Minju Lee, Seunghun Hong
Nanoscale mapping of noise-source-controlled hopping and tunneling conduction in domains of reduced graphene oxide
published pages: 326-335, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2019.03.087
Carbon 148 2019-11-25
2016 Heehong Yang, Daesan Kim, Jeongsu Kim, Dongseok Moon, Hyun Seok Song, Minju Lee, Seunghun Hong, Tai Hyun Park
Nanodisc-Based Bioelectronic Nose Using Olfactory Receptor Produced in Escherichia coli for the Assessment of the Death-Associated Odor Cadaverine
published pages: 11847-11855, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b04992
ACS Nano 11/12 2019-06-18
2017 Viet Anh Pham Ba, Dong-guk Cho, Daesan Kim, Haneul Yoo, Van-Thao Ta, Seunghun Hong
Quantitative electrophysiological monitoring of anti–histamine drug effects on live cells via reusable sensor platforms
published pages: 707-713, ISSN: 0956-5663, DOI: 10.1016/j.bios.2017.03.063
Biosensors and Bioelectronics 94 2019-06-18
2018 Haneul Yoo, Dong Jun Lee, Daesan Kim, Juhun Park, Xing Chen, Seunghun Hong
Magnetically-focusing biochip structures for high-speed active biosensing with improved selectivity
published pages: 265501, ISSN: 0957-4484, DOI: 10.1088/1361-6528/aabc4d
Nanotechnology 29/26 2019-06-18
2017 Youngtak Cho, Narae Shin, Daesan Kim, Jae Yeol Park, Seunghun Hong
Nanoscale hybrid systems based on carbon nanotubes for biological sensing and control
published pages: BSR20160330, ISSN: 0144-8463, DOI: 10.1042/BSR20160330
Bioscience Reports 37/2 2019-06-18
2018 Dong Guk Cho, Haneul Yoo, Haein Lee, Yeol Kyo Choi, Minju Lee, Dong June Ahn, Seunghun Hong
High-Speed Lateral Flow Strategy for a Fast Biosensing with an Improved Selectivity and Binding Affinity
published pages: 1507, ISSN: 1424-8220, DOI: 10.3390/s18051507
Sensors 18/5 2019-06-06
2018 Minju Lee, Heehong Yang, Daesan Kim, Myungjae Yang, Tai Hyun Park, Seunghun Hong
Human-like smelling of a rose scent using an olfactory receptor nanodisc-based bioelectronic nose
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-32155-1
Scientific Reports 8/1 2019-06-07
2019 Viet Anh Pham Ba, Dong-guk Cho, Seunghun Hong
Nafion-Radical Hybrid Films on Carbon Nanotube Transistors for Monitoring Antipsychotic Drug Effects on Stimulated Dopamine Release
published pages: 9716-9723, ISSN: 1944-8244, DOI: 10.1021/acsami.8b18752
ACS Applied Materials & Interfaces 11/10 2019-06-06
2018 Jeongsu Kim, Haneul Yoo, Viet Anh Pham Ba, Narae Shin, Seunghun Hong
Dye-functionalized Sol-gel Matrix on Carbon Nanotubes for Refreshable and Flexible Gas Sensors
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-30481-y
Scientific Reports 8/1 2019-06-06
2018 Byeongho Park, Heehong Yang, Tai Hwan Ha, Hyun Seo Park, Seung Ja Oh, Yong-Sang Ryu, Youngho Cho, Hyo-Suk Kim, Juyeong Oh, Dong Kyu Lee, Chulki Kim, Taikjin Lee, Minah Seo, Jaebin Choi, Young Min Jhon, Deok Ha Woo, Seok Lee, Seok Hwan Kim, Hyuk-Jae Lee, Seong Chan Jun, Hyun Seok Song, Tai Hyun Park, Jae Hun Kim
Artificial Rod and Cone Photoreceptors with Human-Like Spectral Sensitivities
published pages: 1706764, ISSN: 0935-9648, DOI: 10.1002/adma.201706764
Advanced Materials 30/27 2019-06-07

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