NANOZ-ONIC SIGNED
Bio-inspired electrONIC NOSE interfacing olfactory electrical biosensors and carbon NANOtubes
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the NANOZ-ONIC project. It provides you a very rough idea of what is the project "NANOZ-ONIC" about.
Project "NANOZ-ONIC" data sheet
The following table provides information about the project.
| Coordinator |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Organization address contact info |
| Coordinator Country | France [FR] |
| Total cost | 1˙926˙870 € |
| EC max contribution | 1˙926˙870 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-10-01 to 2021-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS | FR (PARIS) | coordinator | 1˙434˙325.00 |
| 2 | SEOUL NATIONAL UNIVERSITY | KR (SEOUL) | participant | 492˙545.00 |
Map
Project objective
The goal of this project is to develop an innovative biosensor for the non-invasive, painless and real-time detection of volatile biomarkers in the exhaled breath of patients. Volatile biomarkers have been identified for several diseases including cancers, diabetes, cystic fibrosis and neurodegeneration. A miniaturized system for fast and simple breath-analysis would not only improve the early detection of these pathologies but also enable point-of-care monitoring of patients either in medical institutions or at home. Different electronic noses are in development (or even in use for diagnosing asthma), however their generalisation in reliable medical diagnosis devices is mainly hindered by their poor versatility. The main challenge is to quantitatively and simultaneously detect several volatile biomarkers with high specificity and selectivity. The ideal technology would be one which mimicked the natural olfactory systems that recognize odours by combinatorial analysis of receptor responses. Inspired by this biological example, this project aims at integrating natural olfactory receptors into two state-of-the-art technologies: Ion Channel-Coupled Receptors (ICCRs) and single-walled Carbon NanoTube-Field Effect Transistors (swCNT-FETs). ICCRs are original biosensors created by fusion of G Protein Coupled Receptors (GPCRs) with an ion channel. The recognition of a chemical compound by the GPCR is transduced into an electrical signal by the ion channel. Mammalian olfactory receptors are GPCRs, and the objective of this 5-year project is to engineer an original library of olfactory ICCRs for multiplex detection of volatile biomarkers. To detect the electrical signal with very high sensitivity and at the nanometric scale, ICCRs will be interfaced with swCNT-FET transistors by coating the carbon nanotubes with ICCR-containing nanovesicles. The recent detection of a biomarker with an ICCR-swCNT-FET device by project members demonstrates the feasibility of this approach.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Viet Anh Pham Ba, Yoo Min Han, Youngtak Cho, Taewan Kim, Byung Yang Lee, Joo Sung Kim, Seunghun Hong Modified Floating Electrode-Based Sensors for the Quantitative Monitoring of Drug Effects on Cytokine Levels Related with Inflammatory Bowel Diseases published pages: 17100-17106, ISSN: 1944-8244, DOI: 10.1021/acsami.8b04287 |
ACS Applied Materials & Interfaces 10/20 | 2019-11-25 |
| 2019 |
Shashank Shekhar, Hyungwoo Lee, Duckhyung Cho, Myungjae Yang, Minju Lee, Seunghun Hong Nanoscale mapping of noise-source-controlled hopping and tunneling conduction in domains of reduced graphene oxide published pages: 326-335, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2019.03.087 |
Carbon 148 | 2019-11-25 |
| 2016 |
Heehong Yang, Daesan Kim, Jeongsu Kim, Dongseok Moon, Hyun Seok Song, Minju Lee, Seunghun Hong, Tai Hyun Park Nanodisc-Based Bioelectronic Nose Using Olfactory Receptor Produced in Escherichia coli for the Assessment of the Death-Associated Odor Cadaverine published pages: 11847-11855, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b04992 |
ACS Nano 11/12 | 2019-06-18 |
| 2017 |
Viet Anh Pham Ba, Dong-guk Cho, Daesan Kim, Haneul Yoo, Van-Thao Ta, Seunghun Hong Quantitative electrophysiological monitoring of anti–histamine drug effects on live cells via reusable sensor platforms published pages: 707-713, ISSN: 0956-5663, DOI: 10.1016/j.bios.2017.03.063 |
Biosensors and Bioelectronics 94 | 2019-06-18 |
| 2018 |
Haneul Yoo, Dong Jun Lee, Daesan Kim, Juhun Park, Xing Chen, Seunghun Hong Magnetically-focusing biochip structures for high-speed active biosensing with improved selectivity published pages: 265501, ISSN: 0957-4484, DOI: 10.1088/1361-6528/aabc4d |
Nanotechnology 29/26 | 2019-06-18 |
| 2017 |
Youngtak Cho, Narae Shin, Daesan Kim, Jae Yeol Park, Seunghun Hong Nanoscale hybrid systems based on carbon nanotubes for biological sensing and control published pages: BSR20160330, ISSN: 0144-8463, DOI: 10.1042/BSR20160330 |
Bioscience Reports 37/2 | 2019-06-18 |
| 2018 |
Dong Guk Cho, Haneul Yoo, Haein Lee, Yeol Kyo Choi, Minju Lee, Dong June Ahn, Seunghun Hong High-Speed Lateral Flow Strategy for a Fast Biosensing with an Improved Selectivity and Binding Affinity published pages: 1507, ISSN: 1424-8220, DOI: 10.3390/s18051507 |
Sensors 18/5 | 2019-06-06 |
| 2018 |
Minju Lee, Heehong Yang, Daesan Kim, Myungjae Yang, Tai Hyun Park, Seunghun Hong Human-like smelling of a rose scent using an olfactory receptor nanodisc-based bioelectronic nose published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-32155-1 |
Scientific Reports 8/1 | 2019-06-07 |
| 2019 |
Viet Anh Pham Ba, Dong-guk Cho, Seunghun Hong Nafion-Radical Hybrid Films on Carbon Nanotube Transistors for Monitoring Antipsychotic Drug Effects on Stimulated Dopamine Release published pages: 9716-9723, ISSN: 1944-8244, DOI: 10.1021/acsami.8b18752 |
ACS Applied Materials & Interfaces 11/10 | 2019-06-06 |
| 2018 |
Jeongsu Kim, Haneul Yoo, Viet Anh Pham Ba, Narae Shin, Seunghun Hong Dye-functionalized Sol-gel Matrix on Carbon Nanotubes for Refreshable and Flexible Gas Sensors published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-30481-y |
Scientific Reports 8/1 | 2019-06-06 |
| 2018 |
Byeongho Park, Heehong Yang, Tai Hwan Ha, Hyun Seo Park, Seung Ja Oh, Yong-Sang Ryu, Youngho Cho, Hyo-Suk Kim, Juyeong Oh, Dong Kyu Lee, Chulki Kim, Taikjin Lee, Minah Seo, Jaebin Choi, Young Min Jhon, Deok Ha Woo, Seok Lee, Seok Hwan Kim, Hyuk-Jae Lee, Seong Chan Jun, Hyun Seok Song, Tai Hyun Park, Jae Hun Kim Artificial Rod and Cone Photoreceptors with Human-Like Spectral Sensitivities published pages: 1706764, ISSN: 0935-9648, DOI: 10.1002/adma.201706764 |
Advanced Materials 30/27 | 2019-06-07 |
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