Opendata, web and dolomites


The escaping B chromosome: a tool for dissecting the mechanisms of Paternal Genome Elimination

Total Cost €


EC-Contrib. €






 BNPGE project word cloud

Explore the words cloud of the BNPGE project. It provides you a very rough idea of what is the project "BNPGE" about.

males    exclusion    inactivation    selfish    appreciated    conduct    researcher    imprinting    mealybug    disorders    implicated    host    primarily    acquire    exploring    extreme    redress    plants    molecularly    conserved    communications    underlying    escape    gene    outreach    genetic    evolutionarily    escapes    strengthen    found    groups    reproduction    viburni    phenomenon    fellow    largely    skills    add    elimination    mammals    publications    epigenetic    transcriptomic    itself    rare    origin    chromosomes    diseases    proposes    conference    form    equip    sperm    genome    dissect    paternal    train    chromosome    public    recognise    unknown    internet    inherited    mother    insect    discard    media    parent    thousands    chance    expand    species    father    network    provides    transmitted    mechanisms    generation    conflict    insights    acquired    regardless    molecular    collaborators    silence    genomic    parental    recognition    return    responsible    evolution    human    independent    capability    bnpge    pseudococcus   

Project "BNPGE" data sheet

The following table provides information about the project.


Organization address
postcode: EH8 9YL

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-01-09   to  2019-01-08


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 183˙454.00


 Project objective

Parent-of-origin effects are considered an important factor in the evolution and development of mammals and plants. Work on genomic imprinting has primarily focused on these two groups, yet reproduction in thousands of insect species involves an extreme form of imprinting known as “Paternal Genome Elimination”. In this case, males recognise, silence and, during sperm formation, discard the chromosomes they inherited from their father. Only the mother’s chromosomes are inherited from the males. The molecular mechanisms responsible for parental origin recognition and process of elimination during sperm formation remain largely unknown. To redress this, BNPGE aims at exploring a unique genomic system found in the mealybug Pseudococcus viburni: a “selfish” B chromosome that has acquired a way to escape from this genomic exclusion, therefore given itself the capability to be transmitted to the next generation regardless of parental origin. Using comparative transcriptomic and genomic analyses, as well as epigenetic approaches, BNPGE proposes to dissect molecularly how this B chromosome escapes from genomic exclusion. This system provides a rare chance to acquire novel insights into the epigenetic mechanisms underlying the recognition and exploitation of a chromosome’s parental origin, a widespread and evolutionarily conserved yet under-appreciated phenomenon. BNPGE will also add new knowledge of applied value as gene inactivation under genetic conflict has been implicated in a wide range of human diseases and disorders. Finally, BNPGE will equip the Fellow to become an independent researcher by enabling her to return and conduct long-term research in the EU, contribute to train and strengthen her research skills, expand her network of collaborators, produce high-impact publications, and enable research dissemination via conference communications and public outreach through the host institution and Internet media.

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