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BodyDMI SIGNED

Development of deuterium metabolic imaging to map body biochemistry with MRI

Total Cost €

EC-Contrib. €

Partnership

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BodyDMI project word cloud

Explore the words cloud of the BodyDMI project. It provides you a very rough idea of what is the project "BodyDMI" about.

designs lack global mcube map opens feasibility treatment 2016 successful patients 45 coils oral organ mhz cancer 3d compounds optimal complement drug linked 2017 designed earlier diabetes spectroscopic innovation humans sensitivity techniques scan dramatic fet setup 300 clinical labeled metabolism image arguably operation combined besides proof diseases mri deuterium array dual body session hepatic loop efficacy lagged resonance commercial disturbances dynamically completion dmi administration uncompromised attributed carbohydrate dynamic idea window epidemic outperformed relies ultra obesity therapies dipole hydrogen transparent scanner mode magnetic detect ed chemical frequency operates outperforms coil toxicity 01 lipid invasive biochemistry tesla valorized morphological metabolic imaging stage

Project "BodyDMI" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	100˙000 €
EC max contribution	100˙000 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-2018-2019-2020-03
Funding Scheme	CSA
Starting year	2019
Duration (year-month-day)	from 2019-06-01 to 2020-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	coordinator	81˙250.00
2	WAVETRONICA BV WAVETRONICA BV Organization address address: PADUALAAN 8 ROOM Z109 city: UTRECHT postcode: 3584 CH website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	18˙750.00
3	MR COILS BV MR COILS BV Organization address address: SHIMMINCK 18 city: ZALTBOMMEL postcode: 5301 KR website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ZALTBOMMEL)	participant	0.00

Map

Project objective

The global obesity epidemic has resulted in a dramatic rise in metabolic diseases and the development of effective therapies has greatly lagged behind. This could arguably be attributed to a lack of non-invasive (imaging) techniques to characterize disturbances in metabolic pathways. We will investigate the use of dynamic deuterium metabolic imaging (DMI) to dynamically map body biochemistry in humans in 3D imaging mode. DMI relies on deuterium magnetic resonance spectroscopic imaging combined with oral administration of deuterium-labeled compounds.

The innovation idea is linked to the MCUBE project of FET-OPEN-01-2016-2017. Here a dual-dipole coil was designed for hydrogen MRI at 7 tesla (300 MHz), which outperformed the state-of-the-art setup of the loop-dipole coil for MRI. The new design is transparent to loop designs, meaning that the setup can be combined with loop coils, which are known to be the optimal setup for low frequency operation. So for DMI, which operates at 45.7 MHz (low frequency) at 7 tesla, an MRI coil array can be designed that not only outperforms MRI, but also enables DMI at uncompromised sensitivity within the same scan session, which will complement the utilization of the MCUBE project.

The objectives of the project are: (1) Build and test a body DMI setup for a clinical ultra-high field 7 tesla MRI scanner; (2) demonstrate proof of concept to measure hepatic carbohydrate and lipid metabolism with DMI; and (3) apply DMI in a clinical feasibility study in type 2 diabetes patients. Upon successful completion of the project, DMI will be valorized by the commercial partners and embedded in clinical practice, which opens up a new window for drug studies to directly image their chemical efficacy. Besides its application in metabolic diseases, DMI has potential to detect organ failure, drug toxicity and effects of cancer treatment in a much earlier stage than morphological imaging.

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