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CF_struct

High-Resolution X-ray Structures of Full-Length Cystic Fibrosis Transmembrane Conductance Regulator

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CF_struct project word cloud

Explore the words cloud of the CF_struct project. It provides you a very rough idea of what is the project "CF_struct" about.

chloride    interdisciplinary    fibrosis    ray    plan    anion    sites    free    biochemistry    kalydeco    agent    cftr    small    lung    action    surface    actualize    biophysics    crystallography    serial    electron    biology    transporter    abc    prestigious    chemistry    fellowship    pharmaceuticals    lethal    crystal    length    programs    outlined    reduces    symptoms    atp    binding    mix    situ    hydrolysis    domain    mode    allosteric    structural    disease    drug    pharmacokinetics    treatment    atpase    trinity    membrane    pharmacological    molecule    sources    revealed    personalized    college    regulatory    career    regulates    distinguished    conductance    functional    ireland    caffrey    sk    optimization    gating    lasers    foundation    resolution    cf    vertex    initial    death    ion    candidate    computational    epithelial    alone    bowel    family    cystic    full    independent    obstruction    regulator    meso    structure    odowska    ligand    crystallized    place    femtosecond    marie    dr    lab    researcher    synchrotron    premature    lumen    proteins    residues    transmembrane    specificity    concentration    cells    martin    channel    transporters    gene    begin    exposed    iterative    cassette    found    latest    curie    mutations    actions    dublin   

Project "CF_struct" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website https://fetics411899018.wordpress.com/probe-european-researchers-night-2018/
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-16   to  2018-11-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 175˙866.00

Map

 Project objective

This proposal seeks to solve the high-resolution X-ray crystal structure of full-length Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), an anion channel which regulates chloride ion concentration at the lumen-exposed surface of epithelial cells. Mutations of the CFTR gene cause cystic fibrosis (CF), a lethal disease which results in bowel obstruction, lung disease and premature death. CFTR is an ATPase and a member of the ATP-Binding Cassette (ABC) transporter family of proteins which has an allosteric Regulatory (R) domain not found in other ABC transporters. From the structure of CFTR, its mode of action will be revealed, focusing on the two sites of ATP hydrolysis and key residues for channel gating. CFTR will be crystallized alone and in the presence of the pharmacological agent Kalydeco, a small molecule from Vertex Pharmaceuticals that is used for the treatment of CF and reduces CF symptoms. The initial high-resolution X-ray crystal structure is a foundation from which personalized drug design work can begin. Therefore, the Kalydeco-CFTR complex structure will be used for ligand optimization of Kalydeco, an iterative process which will improve Kalydeco’s specificity and pharmacokinetics. The latest technology, including in meso in situ serial crystallography and X-ray free electron lasers for serial femtosecond crystallography will be used as well as traditional synchrotron X-ray sources. These Actions use an interdisciplinary mix of crystallography, chemistry, biochemistry, biophysics and computational structural determination programs. The work will take place in Ireland in the lab of Dr. Martin Caffrey at Trinity College Dublin, a distinguished researcher in the field of membrane structural and functional biology. The prestigious Marie SkÅ‚odowska-Curie fellowship will enable the candidate to actualize many objectives outlined in her career development plan in order to become an independent researcher.

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The information about "CF_STRUCT" are provided by the European Opendata Portal: CORDIS opendata.

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