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CF_struct

High-Resolution X-ray Structures of Full-Length Cystic Fibrosis Transmembrane Conductance Regulator

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CF_struct project word cloud

Explore the words cloud of the CF_struct project. It provides you a very rough idea of what is the project "CF_struct" about.

crystal    obstruction    functional    exposed    revealed    computational    regulator    chemistry    regulatory    serial    lumen    mutations    bowel    treatment    personalized    cassette    length    family    allosteric    career    fellowship    odowska    epithelial    proteins    dublin    distinguished    meso    found    disease    lab    synchrotron    fibrosis    chloride    college    death    crystallography    biochemistry    domain    conductance    vertex    abc    caffrey    symptoms    plan    regulates    mode    surface    cftr    independent    iterative    lung    gating    pharmacokinetics    optimization    structure    ireland    sites    pharmaceuticals    electron    actions    structural    crystallized    ray    prestigious    foundation    action    transporters    residues    hydrolysis    resolution    programs    alone    sk    specificity    situ    gene    curie    sources    martin    latest    drug    full    lasers    agent    researcher    ion    transmembrane    transporter    anion    pharmacological    binding    begin    atpase    mix    place    marie    premature    trinity    free    cells    dr    membrane    ligand    candidate    kalydeco    initial    femtosecond    small    channel    outlined    biology    lethal    biophysics    cystic    atp    actualize    interdisciplinary    reduces    concentration    molecule    cf   

Project "CF_struct" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website https://fetics411899018.wordpress.com/probe-european-researchers-night-2018/
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-16   to  2018-11-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 175˙866.00

Map

 Project objective

This proposal seeks to solve the high-resolution X-ray crystal structure of full-length Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), an anion channel which regulates chloride ion concentration at the lumen-exposed surface of epithelial cells. Mutations of the CFTR gene cause cystic fibrosis (CF), a lethal disease which results in bowel obstruction, lung disease and premature death. CFTR is an ATPase and a member of the ATP-Binding Cassette (ABC) transporter family of proteins which has an allosteric Regulatory (R) domain not found in other ABC transporters. From the structure of CFTR, its mode of action will be revealed, focusing on the two sites of ATP hydrolysis and key residues for channel gating. CFTR will be crystallized alone and in the presence of the pharmacological agent Kalydeco, a small molecule from Vertex Pharmaceuticals that is used for the treatment of CF and reduces CF symptoms. The initial high-resolution X-ray crystal structure is a foundation from which personalized drug design work can begin. Therefore, the Kalydeco-CFTR complex structure will be used for ligand optimization of Kalydeco, an iterative process which will improve Kalydeco’s specificity and pharmacokinetics. The latest technology, including in meso in situ serial crystallography and X-ray free electron lasers for serial femtosecond crystallography will be used as well as traditional synchrotron X-ray sources. These Actions use an interdisciplinary mix of crystallography, chemistry, biochemistry, biophysics and computational structural determination programs. The work will take place in Ireland in the lab of Dr. Martin Caffrey at Trinity College Dublin, a distinguished researcher in the field of membrane structural and functional biology. The prestigious Marie SkÅ‚odowska-Curie fellowship will enable the candidate to actualize many objectives outlined in her career development plan in order to become an independent researcher.

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The information about "CF_STRUCT" are provided by the European Opendata Portal: CORDIS opendata.

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