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CF_struct

High-Resolution X-ray Structures of Full-Length Cystic Fibrosis Transmembrane Conductance Regulator

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CF_struct project word cloud

Explore the words cloud of the CF_struct project. It provides you a very rough idea of what is the project "CF_struct" about.

anion    prestigious    cf    agent    pharmaceuticals    lethal    ligand    chemistry    cftr    transporter    symptoms    foundation    proteins    caffrey    lasers    lung    pharmacological    electron    disease    martin    structural    drug    gating    researcher    odowska    synchrotron    specificity    obstruction    conductance    family    marie    kalydeco    crystallized    trinity    college    revealed    computational    residues    initial    lab    independent    meso    transmembrane    cystic    dr    allosteric    regulatory    length    serial    free    personalized    optimization    plan    ion    regulator    interdisciplinary    regulates    programs    surface    treatment    death    molecule    transporters    concentration    full    atp    ireland    channel    actualize    career    hydrolysis    domain    latest    vertex    fibrosis    abc    distinguished    chloride    biochemistry    ray    sites    fellowship    biophysics    mix    femtosecond    mode    actions    epithelial    structure    sources    biology    binding    membrane    lumen    premature    place    reduces    action    crystal    functional    gene    alone    curie    sk    outlined    dublin    candidate    exposed    situ    cells    found    resolution    pharmacokinetics    small    crystallography    bowel    begin    mutations    cassette    atpase    iterative   

Project "CF_struct" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website https://fetics411899018.wordpress.com/probe-european-researchers-night-2018/
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-16   to  2018-11-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 175˙866.00

Map

 Project objective

This proposal seeks to solve the high-resolution X-ray crystal structure of full-length Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), an anion channel which regulates chloride ion concentration at the lumen-exposed surface of epithelial cells. Mutations of the CFTR gene cause cystic fibrosis (CF), a lethal disease which results in bowel obstruction, lung disease and premature death. CFTR is an ATPase and a member of the ATP-Binding Cassette (ABC) transporter family of proteins which has an allosteric Regulatory (R) domain not found in other ABC transporters. From the structure of CFTR, its mode of action will be revealed, focusing on the two sites of ATP hydrolysis and key residues for channel gating. CFTR will be crystallized alone and in the presence of the pharmacological agent Kalydeco, a small molecule from Vertex Pharmaceuticals that is used for the treatment of CF and reduces CF symptoms. The initial high-resolution X-ray crystal structure is a foundation from which personalized drug design work can begin. Therefore, the Kalydeco-CFTR complex structure will be used for ligand optimization of Kalydeco, an iterative process which will improve Kalydeco’s specificity and pharmacokinetics. The latest technology, including in meso in situ serial crystallography and X-ray free electron lasers for serial femtosecond crystallography will be used as well as traditional synchrotron X-ray sources. These Actions use an interdisciplinary mix of crystallography, chemistry, biochemistry, biophysics and computational structural determination programs. The work will take place in Ireland in the lab of Dr. Martin Caffrey at Trinity College Dublin, a distinguished researcher in the field of membrane structural and functional biology. The prestigious Marie SkÅ‚odowska-Curie fellowship will enable the candidate to actualize many objectives outlined in her career development plan in order to become an independent researcher.

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The information about "CF_STRUCT" are provided by the European Opendata Portal: CORDIS opendata.

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