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CF_struct

High-Resolution X-ray Structures of Full-Length Cystic Fibrosis Transmembrane Conductance Regulator

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CF_struct project word cloud

Explore the words cloud of the CF_struct project. It provides you a very rough idea of what is the project "CF_struct" about.

exposed    conductance    atp    cystic    femtosecond    gene    ireland    gating    crystallography    dr    proteins    meso    functional    interdisciplinary    membrane    alone    ion    synchrotron    resolution    regulatory    cf    transporter    independent    regulator    binding    treatment    epithelial    free    vertex    surface    actualize    curie    specificity    reduces    hydrolysis    structural    cassette    transmembrane    concentration    mode    career    drug    trinity    pharmacological    programs    full    obstruction    ray    begin    plan    optimization    personalized    molecule    cftr    latest    situ    crystallized    lumen    outlined    sources    abc    candidate    lung    serial    action    revealed    pharmaceuticals    symptoms    dublin    chemistry    researcher    initial    length    caffrey    agent    death    fibrosis    prestigious    transporters    crystal    domain    biology    bowel    cells    allosteric    distinguished    iterative    sk    odowska    foundation    premature    pharmacokinetics    residues    small    lethal    found    structure    martin    disease    mutations    channel    biophysics    fellowship    ligand    family    anion    lasers    lab    college    mix    biochemistry    kalydeco    sites    computational    chloride    electron    actions    regulates    place    atpase    marie   

Project "CF_struct" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website https://fetics411899018.wordpress.com/probe-european-researchers-night-2018/
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-16   to  2018-11-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 175˙866.00

Map

 Project objective

This proposal seeks to solve the high-resolution X-ray crystal structure of full-length Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), an anion channel which regulates chloride ion concentration at the lumen-exposed surface of epithelial cells. Mutations of the CFTR gene cause cystic fibrosis (CF), a lethal disease which results in bowel obstruction, lung disease and premature death. CFTR is an ATPase and a member of the ATP-Binding Cassette (ABC) transporter family of proteins which has an allosteric Regulatory (R) domain not found in other ABC transporters. From the structure of CFTR, its mode of action will be revealed, focusing on the two sites of ATP hydrolysis and key residues for channel gating. CFTR will be crystallized alone and in the presence of the pharmacological agent Kalydeco, a small molecule from Vertex Pharmaceuticals that is used for the treatment of CF and reduces CF symptoms. The initial high-resolution X-ray crystal structure is a foundation from which personalized drug design work can begin. Therefore, the Kalydeco-CFTR complex structure will be used for ligand optimization of Kalydeco, an iterative process which will improve Kalydeco’s specificity and pharmacokinetics. The latest technology, including in meso in situ serial crystallography and X-ray free electron lasers for serial femtosecond crystallography will be used as well as traditional synchrotron X-ray sources. These Actions use an interdisciplinary mix of crystallography, chemistry, biochemistry, biophysics and computational structural determination programs. The work will take place in Ireland in the lab of Dr. Martin Caffrey at Trinity College Dublin, a distinguished researcher in the field of membrane structural and functional biology. The prestigious Marie SkÅ‚odowska-Curie fellowship will enable the candidate to actualize many objectives outlined in her career development plan in order to become an independent researcher.

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The information about "CF_STRUCT" are provided by the European Opendata Portal: CORDIS opendata.

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