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CF_struct

High-Resolution X-ray Structures of Full-Length Cystic Fibrosis Transmembrane Conductance Regulator

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CF_struct project word cloud

Explore the words cloud of the CF_struct project. It provides you a very rough idea of what is the project "CF_struct" about.

drug    pharmacological    latest    gene    regulates    atp    sk    trinity    cells    small    reduces    regulator    iterative    disease    biochemistry    marie    ireland    meso    prestigious    electron    structural    free    membrane    cystic    chloride    actions    sites    regulatory    crystallized    conductance    biophysics    foundation    ray    family    ion    premature    candidate    place    domain    curie    programs    lumen    situ    dublin    interdisciplinary    distinguished    caffrey    lasers    mode    biology    ligand    sources    fibrosis    channel    mix    gating    lung    crystallography    allosteric    surface    cftr    residues    transporters    actualize    begin    pharmaceuticals    structure    vertex    plan    transporter    abc    molecule    atpase    optimization    death    concentration    proteins    independent    functional    agent    synchrotron    computational    specificity    obstruction    outlined    epithelial    cassette    symptoms    full    alone    career    pharmacokinetics    crystal    resolution    personalized    mutations    length    lab    exposed    serial    odowska    initial    transmembrane    revealed    cf    anion    researcher    bowel    hydrolysis    fellowship    lethal    dr    martin    kalydeco    chemistry    binding    action    treatment    college    found    femtosecond   

Project "CF_struct" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website https://fetics411899018.wordpress.com/probe-european-researchers-night-2018/
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-16   to  2018-11-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 175˙866.00

Map

 Project objective

This proposal seeks to solve the high-resolution X-ray crystal structure of full-length Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), an anion channel which regulates chloride ion concentration at the lumen-exposed surface of epithelial cells. Mutations of the CFTR gene cause cystic fibrosis (CF), a lethal disease which results in bowel obstruction, lung disease and premature death. CFTR is an ATPase and a member of the ATP-Binding Cassette (ABC) transporter family of proteins which has an allosteric Regulatory (R) domain not found in other ABC transporters. From the structure of CFTR, its mode of action will be revealed, focusing on the two sites of ATP hydrolysis and key residues for channel gating. CFTR will be crystallized alone and in the presence of the pharmacological agent Kalydeco, a small molecule from Vertex Pharmaceuticals that is used for the treatment of CF and reduces CF symptoms. The initial high-resolution X-ray crystal structure is a foundation from which personalized drug design work can begin. Therefore, the Kalydeco-CFTR complex structure will be used for ligand optimization of Kalydeco, an iterative process which will improve Kalydeco’s specificity and pharmacokinetics. The latest technology, including in meso in situ serial crystallography and X-ray free electron lasers for serial femtosecond crystallography will be used as well as traditional synchrotron X-ray sources. These Actions use an interdisciplinary mix of crystallography, chemistry, biochemistry, biophysics and computational structural determination programs. The work will take place in Ireland in the lab of Dr. Martin Caffrey at Trinity College Dublin, a distinguished researcher in the field of membrane structural and functional biology. The prestigious Marie SkÅ‚odowska-Curie fellowship will enable the candidate to actualize many objectives outlined in her career development plan in order to become an independent researcher.

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The information about "CF_STRUCT" are provided by the European Opendata Portal: CORDIS opendata.

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