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Stereocontrolled Polymerisation: New Frontiers in Synthesis and Supramolecular Self Assembly

Total Cost €


EC-Contrib. €






Project "STEREOPOL" data sheet

The following table provides information about the project.


Organization address
address: Edgbaston
postcode: B15 2TT

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 2˙074˙731 €
 EC max contribution 2˙074˙731 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 1˙621˙878.00
2    THE UNIVERSITY OF WARWICK UK (COVENTRY) participant 452˙852.00


 Project objective

Nature has evolved the ability to create large and complex molecules in which the 3-dimensional orientation of the atoms is critical to their performance. The essential nature of stereochemistry to the structure, and hence performance, of biopolymers makes it reasonable to expect such aspects of synthetic materials to be equally important. This area has however received little study, which is partially a consequence of the significant challenges of creating large macromolecules with well-defined stereochemistry at each repeat unit. This proposal is inspired by nature, to design polymers with exquisite structural control in which the behaviour and properties of the resultant materials will be dependent on their stereochemistry. Specifically, it will address the limitations in synthetic methodology for creating complex, functional stereocontrolled polymers and demonstrate the true potential of harnessing polymer materials with controlled stereochemistry. We will achieve this by focussing on the development of new methodologies for stereocontrolled ring-opening polymerisation of cyclic esters such that we will be able to readily access stereoregular, functional polymers, including achieving unique sequence controlled materials. While one focus will be on utilising renewable resources and green polymer synthesis methodologies, we will also take the first steps to demonstrating the utility of these novel materials by investigating the effects of stereochemistry on the bulk properties of materials as well as its ability to drive crystallisation-driven self-assembly and stereo-responsive nanoparticle behaviour for delivery applications. Achieving these goals promises to take polymers into the 3rd dimension and lead to significant technological breakthroughs in nanotechnology, medicine and sustainable materials among other areas of key future technological importance.


year authors and title journal last update
List of publications.
2018 Laura J. Macdougall, Katherine L. Wiley, April M. Kloxin, Andrew P. Dove
Design of synthetic extracellular matrices for probing breast cancer cell growth using robust cyctocompatible nucleophilic thiol-yne addition chemistry
published pages: 435-447, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.04.046
Biomaterials 178 2020-04-15
2019 Connor J. Stubbs, Joshua C. Worch, Hannah Prydderch, Matthew L. Becker, Andrew P. Dove
Unsaturated Poly(ester-urethanes) with Stereochemically Dependent Thermomechanical Properties
published pages: 174-181, ISSN: 0024-9297, DOI: 10.1021/acs.macromol.9b01700
Macromolecules 53/1 2020-04-15
2017 Guillaume Hedir, Christopher Stubbs, Phillip Aston, Andrew P. Dove, Matthew I. Gibson
Synthesis of Degradable Poly(vinyl alcohol) by Radical Ring-Opening Copolymerization and Ice Recrystallization Inhibition Activity
published pages: 1404-1408, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.7b00905
ACS Macro Letters 6/12 2020-04-15
2019 Yunxiang He, Jean-Charles Eloi, Robert L. Harniman, Robert M. Richardson, George R. Whittell, Robert T. Mathers, Andrew P. Dove, Rachel K. O’Reilly, Ian Manners
Uniform Biodegradable Fiber-Like Micelles and Block Comicelles via “Living” Crystallization-Driven Self-Assembly of Poly( l -lactide) Block Copolymers: The Importance of Reducing Unimer Self-Nucleation via Hydrogen Bond Disruption
published pages: 19088-19098, ISSN: 0002-7863, DOI: 10.1021/jacs.9b09885
Journal of the American Chemical Society 141/48 2020-04-15
2018 Maria C. Arno, Ruairí P. Brannigan, Gina M. Policastro, Matthew L. Becker, Andrew P. Dove
pH-Responsive, Functionalizable Spyrocyclic Polycarbonate: A Versatile Platform for Biocompatible Nanoparticles
published pages: 3427-3434, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b00744
Biomacromolecules 19/8 2020-04-15
2017 Laura J. Macdougall, Maria M. Pérez-Madrigal, Maria C. Arno, Andrew P. Dove
Nonswelling Thiol–Yne Cross-Linked Hydrogel Materials as Cytocompatible Soft Tissue Scaffolds
published pages: 1378-1388, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b01204
Biomacromolecules 19/5 2020-04-15
2018 Laura J. Macdougall, Maria M. Pérez-Madrigal, Joshua E. Shaw, Maria Inam, Judith A. Hoyland, Rachel O\'Reilly, Stephen M. Richardson, Andrew P. Dove
Self-healing, stretchable and robust interpenetrating network hydrogels
published pages: 2932-2937, ISSN: 2047-4830, DOI: 10.1039/c8bm00872h
Biomaterials Science 6/11 2020-04-15
2020 Maria C. Arno, Maria Inam, Andrew C. Weems, Zehua Li, Abbie L. A. Binch, Christopher I. Platt, Stephen M. Richardson, Judith A. Hoyland, Andrew P. Dove, Rachel K. O’Reilly
Exploiting the role of nanoparticle shape in enhancing hydrogel adhesive and mechanical properties
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-020-15206-y
Nature Communications 11/1 2020-04-15
2018 Beste Orhan, Mathieu J.-L. Tschan, Anne-Laure Wirotius, Andrew P. Dove, Olivier Coulembier, Daniel Taton
Isoselective Ring-Opening Polymerization of rac -Lactide from Chiral Takemoto’s Organocatalysts: Elucidation of Stereocontrol
published pages: 1413-1419, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.8b00852
ACS Macro Letters 7/12 2020-04-15
2019 Joshua C. Worch, Hannah Prydderch, Sètuhn Jimaja, Panagiotis Bexis, Matthew L. Becker, Andrew P. Dove
Stereochemical enhancement of polymer properties
published pages: 514-535, ISSN: 2397-3358, DOI: 10.1038/s41570-019-0117-z
Nature Reviews Chemistry 3/9 2020-04-15
2017 Maria Inam, Joseph R. Jones, Maria M. Pérez-Madrigal, Maria C. Arno, Andrew P. Dove, Rachel K. O’Reilly
Controlling the Size of Two-Dimensional Polymer Platelets for Water-in-Water Emulsifiers
published pages: 63-70, ISSN: 2374-7943, DOI: 10.1021/acscentsci.7b00436
ACS Central Science 4/1 2020-04-15
2017 Wei Yu, Maria Inam, Joseph R. Jones, Andrew P. Dove, Rachel K. O\'Reilly
Understanding the CDSA of poly(lactide) containing triblock copolymers
published pages: 5504-5512, ISSN: 1759-9954, DOI: 10.1039/C7PY01056G
Polymer Chemistry 8/36 2019-06-18
2017 Guillaume G. Hedir, Maria C. Arno, Marvin Langlais, Jonathan T. Husband, Rachel K. O\'Reilly, Andrew P. Dove
Poly(oligo(ethylene glycol) vinyl acetate)s: A Versatile Class of Thermoresponsive and Biocompatible Polymers
published pages: 9178-9182, ISSN: 1433-7851, DOI: 10.1002/anie.201703763
Angewandte Chemie International Edition 56/31 2019-06-18
2017 Maria Inam, Graeme Cambridge, Anaïs Pitto-Barry, Zachary P. L. Laker, Neil R. Wilson, Robert T. Mathers, Andrew P. Dove, Rachel K. O\'Reilly
1D vs. 2D shape selectivity in the crystallization-driven self-assembly of polylactide block copolymers
published pages: 4223-4230, ISSN: 2041-6520, DOI: 10.1039/C7SC00641A
Chemical Science 8/6 2019-06-18
2017 Maria C. Arno, Maria Inam, Zachary Coe, Graeme Cambridge, Laura J. Macdougall, Robert Keogh, Andrew P. Dove, Rachel K. O’Reilly
Precision Epitaxy for Aqueous 1D and 2D Poly(ε-caprolactone) Assemblies
published pages: 16980-16985, ISSN: 0002-7863, DOI: 10.1021/jacs.7b10199
Journal of the American Chemical Society 139/46 2019-06-18
2017 Mathieu J.-L. Tschan, Nga Sze Ieong, Richard Todd, Jack Everson, Andrew P. Dove
Unlocking the Potential of Poly( Ortho Ester)s: A General Catalytic Approach to the Synthesis of Surface-Erodible Materials
published pages: 16664-16668, ISSN: 1433-7851, DOI: 10.1002/anie.201709934
Angewandte Chemie International Edition 56/52 2019-06-18

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