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MDR Tuberculosis SIGNED

Evolution and success of the multi-drug resistant M. tuberculosis SIT41 (LAM7-TUR) lineage

Total Cost €

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EC-Contrib. €

0

Partnership

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 MDR Tuberculosis project word cloud

Explore the words cloud of the MDR Tuberculosis project. It provides you a very rough idea of what is the project "MDR Tuberculosis" about.

international    american    molecular    rapid    generation    2013    screening    area    efficacy    snp    type    limit    sensitive    lam7    resistant    surveillance    programs    marker    horizon    exploring    strategy    treatment    burden    technologies    spoligo    tracking    97    sequencing    tb    confirmed    relevance    lineage    multidrug    first    play    patients    expansion    resistance    origins    time    latin    radically    personalising    infected    data    mtb    mutation    lunched    diseases    typing    identification    lam    association    shown    strains    drug    bulgaria    urgent    emergence    mediterranean    pathogen    line    ecdc    mycobacterium    center    genotype    strain    sit41    hyper    improvement    humans    reducing    2020    ideas    personalised    methodology    mdr    prevention    health    vaccine    care    beijing    statistically    genotyping    tuberculostatics    evolution    tur    lineages    outcome    scheme    sit    disease    tuberculosis    variation    transmissibility   

Project "MDR Tuberculosis" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE PARIS-SUD 

Organization address
address: RUE GEORGES CLEMENCEAU 15
city: ORSAY CEDEX
postcode: 91405
website: www.u-psud.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://www.universite-paris-saclay.fr/fr/stefan-panaiotov
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE PARIS-SUD FR (ORSAY CEDEX) coordinator 185˙076.00

Map

 Project objective

Mycobacterium tuberculosis (MTB) is the cause of tuberculosis (TB) in humans. Identification of the MTB lineage is of importance to tuberculosis control as it has shown that strain type may play a role in disease outcome, variation in vaccine efficacy and emergence of drug resistance. MTB strains of Beijing and Latin-American-Mediterranean (LAM) lineages were associated with hyper-transmissibility and drug resistance. In 2013 the European Center for Diseases Prevention and Control (ECDC) effectively lunched molecular surveillance of MDR TB at EU level. The typing of M. tuberculosis strains in Bulgaria confirmed strong association between MDR and SIT41 (LAM7-TUR) [SIT – Spoligo International Type] MTB lineage. Statistically 97% of the TB patients infected with drug sensitive SIT41 MTB strain develop MDR tuberculosis. SIT41 is marker genotype for MDR TB. Urgent measures are needed to control and limit the expansion of the SIT41 lineage. We aim to promote personalised treatment of tuberculosis based on the genotype lineage of the TB pathogen and reducing the TB multidrug-resistant burden. The project has two objectives. First: Application of the next-generation sequencing data for genotyping of M. tuberculosis strains based on SNP data for tracking the origins, evolution and success of the SIT41 (LAM7-TUR) lineage, and second: Development of rapid screening methodology to identify the SIT41 (LAM7-TUR) genotype including mutation analysis to first and second line tuberculostatics drug resistance. Objectives will be achieved by fostering radically new technologies, by exploring novel ideas for MTB genotyping and improvement of the classical TB treatment scheme. The project is timely because it has relevance to the Work Program Horizon 2020 focus area: Personalising health and care. For the first time we will promote personalised treatment associated with specific MTB genotype. The proposal is in line with the EU Health Strategy, ECDC, WHO and other TB control programs.

 Publications

year authors and title journal last update
List of publications.
2016 Jody E. Phelan, Francesc Coll, Indra Bergval, Richard M. Anthony, Rob Warren, Samantha L. Sampson, Nicolaas C. Gey van Pittius, Judith R. Glynn, Amelia C. Crampin, Adriana Alves, Theolis Barbosa Bessa, Susana Campino, Keertan Dheda, Louis Grandjean, Rumina Hasan, Zahra Hasan, Anabela Miranda, David Moore, Stefan Panaiotov, Joao Perdigao, Isabel Portugal, Patricia Sheen, Erivelton de Oliveira Sousa, Elizabeth M. Streicher, Paul D. van Helden, Miguel Viveiros, Martin L. Hibberd, Arnab Pain, Ruth McNerney, Taane G. Clark
Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-016-2467-y
BMC Genomics 17/1 2019-06-18
2017 S. Panaiotov, E. Bachiyska, S. Yordanova, Y. Atanasova, Y. Todorova, V. Levterova, I. Simeonovski, A. Karcheva, T. Kantardjiev
Drivers of Mycobacterium tuberculosis Biodiversity in Bulgaria
published pages: , ISSN: , DOI:
ASM Microbe 2017 Conference Abstr 3664 2019-06-18
2017 S Panaiotov, A Karcheva, E Bachiyska, V. Levterova, N Brankova, I Simeonovski, T Kantardjiev
Biodiversity of M. tuberculosis strains from Central North Bulgaria
published pages: , ISSN: , DOI:
15th Congress of the Bulgarian Association of Microbiologists 2017 2019-06-18
2016 S. Panaiotov, E. Bachiyska, S. Yordanova,Y. Atanasova, Y. .Todorova, V. Levterova, N. Brankova, I. Simeonovski, K. Tankova, Ts. Stefanova, A. Karcheva, T. Kantardjiev
Genetic biodiversity of drug sensitive and multidrug resistant strains of Mycobacterium tuberculosis in Bulgaria.
published pages: , ISSN: 1312-2193, DOI:
Medical Review 2016, 52(3):47-54 2019-06-18
2017 Reni Kalfin, Georgi Filevski, Michele Equestre, Elena Nikolova, Stefan Panaiotov
Dormant fungi in the blood microbiome of healthy individuals
published pages: , ISSN: 2046-1402, DOI: 10.7490/f1000research.1114446.1
F1000 Research 2017 6:1168 2019-06-18
2017 S. Panaiotov, G. Filevski, M. Equestre, E. Nikolova, R. Kalfin
Characteristics of the dormant blood microbiota of healthy individuals
published pages: , ISSN: , DOI:
BioSpektrum 828/PWP 2019-06-18
2017 S Panaiotov, A Kurchatova, I Filipova, V Levterova, N Brankova, I Simeonovski, T Kantardjiev.
Bacterial meningitis in Bulgaria: 2013-2016
published pages: , ISSN: , DOI:
27th ECCMID Congress 2017 P2107 2019-06-18
2017 Panaiotov S, Filevski G, Equestre M et al.
Transmission analysis of a multidrug-resistant Mycobacterium tuberculosis outbreak in Bulgaria
published pages: , ISSN: 2046-1402, DOI: 10.7490/f1000research.1114445.1
F 1000 Research 2017 6:1165 2019-06-18
2017 S Panaiotov, D Madjarov, E Bachiyska, S Yordanova, Y Atanasova, Y Todorova, V Levterova, N Brankova, I Simeonovski, K Tankova, Ts Stefanova, T Kantardjiev
Factors associated with biodiversity of M. tuberculosis in Bulgaria
published pages: , ISSN: , DOI:
15th Congress of Bulgarian Association of Microbiologists 2017 2019-06-18
2017 Stefan Panaiotov
MDR-TB SIT41_MIRU-VNTR genotyping dataset
published pages: , ISSN: , DOI: 10.5281/zenodo.1065289
2019-06-18
2017 Panaiotov S, Bachiyska E, Yordanova S et al.
Resuscitation of latent M. tuberculosis?
published pages: , ISSN: 2046-1402, DOI: 10.7490/f1000research.1114443.1
F1000 Research 2017 6:1165 2019-06-18
2016 Guislaine Refrégier, Edgar Abadia, Tomoshige Matsumoto, Hiromi Ano, Tetsuya Takashima, Izuo Tsuyuguchi, Elif Aktas, Füsun Cömert, Michel Kireopori Gomgnimbou, Stefan Panaiotov, Jody Phelan, Francesc Coll, Ruth McNerney, Arnab Pain, Taane G. Clark, Christophe Sola
Turkish and Japanese Mycobacterium tuberculosis sublineages share a remote common ancestor
published pages: 461-473, ISSN: 1567-1348, DOI: 10.1016/j.meegid.2016.10.009
Infection, Genetics and Evolution 45 2019-06-18
2017 S Panaiotov, E Bachiyska, S Yordanova, Y Atanasova, Y Todorova, V Levterova, N Brankova, I Simeonovski, A Karcheva, R Guislaine, C Sola, T Kantardjiev
Molecular biodiversity of Mycobacterium tuberculosis in Bulgaria: 2007-2016
published pages: , ISSN: , DOI:
27th ECCMID Congress 2017 P1633 2019-06-18
2015 Yordanova, S., Bachiyska, E., Atanasova, Y., Todorova, Y., Baikova, A.. Panaiotov, S., Kantardjiev, T.
MDR-TB with additional fluoroquinolone resistance in Bulgaria
published pages: , ISSN: 0204-9155, DOI:
Probl Infect Parasit Dis 43(2):8-11 2019-06-18
2017 S. Panaiotov, E. Bachiyska, S. Yordanova, Y. Atanasova, Y. Todorova, V. Levterova, N. Brankova, I. Simeonovski, A. Karcheva, G. Refregier, C. Sola
Abstractbook of the Joint Conference 2017 of the DGHM & VAAM: Microbiology and Infection
published pages: 1-377, ISSN: 0947-0867, DOI: 10.1007/s12268-017-0772-x
BIOspektrum 23/S1 2019-06-18

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