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RENOIR SIGNED

RENal prOgenItoRs as tools to understand kidney pathophysiology and treat kidney disorders

Total Cost €

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EC-Contrib. €

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Partnership

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Project "RENOIR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI FIRENZE 

Organization address
address: Piazza San Marco 4
city: Florence
postcode: 50121
website: http://www.unifi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.renalprogenitorsflorence.com
 Total cost 1˙772˙718 €
 EC max contribution 1˙772˙718 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) coordinator 1˙772˙718.00

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 Project objective

Kidney disorders represent a major global health issue and new tools are needed to expand disease modeling and therapeutic options. The identification of renal progenitors (RPC) opens a wide range of possibilities to support progress in several fields of nephrology. Indeed, RPC have become a key player in the pathogenesis of kidney disorders, and their study is increasing knowledge about the mechanisms of kidney response to injury. In this project we propose new lineage tracing models to identify and characterize mouse RPC system. We then will use these models to establish RPC role in progression or resolution of glomerular and tubular injury, and the mechanisms involved in these processes. Furthermore, the role of abnormal RPC function in the pathogenesis of renal cell carcinoma will be established. We will proceed to validate RPC as therapeutic targets to improve podocyte regeneration and disease regression. Lineage tracing of the murine RPC system from development to adult life and characterization of the RPC niche will be performed through observation of RPC at various stages of nephron formation during development as well as during kidney growth, homeostasis and aging. RPC isolation and culture from kidney tissue being limited due to their inaccessibility, the recent development of a method for culturing them specifically from urine finally opens the perspective of personalized medicine of the kidney and the development of patient-specific treatment strategies. In addition, patient-specific RPC can be useful for screening of new drug compounds, developing disease-modifying assays, as well as for evaluation of drug toxicity, with particular regard to nephrotoxicity. Finally, RPC represent potential tools and/or targets for therapeutic purposes and to promote innovative renal replacement strategies for kidney disorders.

 Publications

year authors and title journal last update
List of publications.
2019 Maria Elena Melica, Gilda La Regina, Matteo Parri, Anna Julie Peired, Paola Romagnani, Laura Lasagni
Substrate Stiffness Modulates Renal Progenitor Cell Properties via a ROCK-Mediated Mechanotransduction Mechanism
published pages: 1561, ISSN: 2073-4409, DOI: 10.3390/cells8121561
Cells 8/12 2020-02-28
2019 Maria Lucia Angelotti, Giulia Antonelli, Carolina Conte, Paola Romagnani
Imaging the kidney: from light to super-resolution microscopy
published pages: , ISSN: 0931-0509, DOI: 10.1093/ndt/gfz136
Nephrology Dialysis Transplantation 2020-02-28
2019 Elena Lazzeri, Maria Lucia Angelotti, Carolina Conte, Hans-Joachim Anders, Paola Romagnani
Surviving Acute Organ Failure: Cell Polyploidization and Progenitor Proliferation
published pages: 366-381, ISSN: 1471-4914, DOI: 10.1016/j.molmed.2019.02.006
Trends in Molecular Medicine 25/5 2020-02-28
2019 Francesco Guzzi, Luigi Cirillo, Rosa Maria Roperto, Paola Romagnani, Elena Lazzeri
Molecular Mechanisms of the Acute Kidney Injury to Chronic Kidney Disease Transition: An Updated View
published pages: 4941, ISSN: 1422-0067, DOI: 10.3390/ijms20194941
International Journal of Molecular Sciences 20/19 2020-02-28
2018 Elena Lazzeri, Maria Lucia Angelotti, Anna Peired, Carolina Conte, Julian A. Marschner, Laura Maggi, Benedetta Mazzinghi, Duccio Lombardi, Maria Elena Melica, Sara Nardi, Elisa Ronconi, Alessandro Sisti, Giulia Antonelli, Francesca Becherucci, Letizia De Chiara, Ricardo Romero Guevara, Alexa Burger, Beat Schaefer, Francesco Annunziato, Hans-Joachim Anders, Laura Lasagni, Paola Romagnani
Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03753-4
Nature Communications 9/1 2019-06-06
2015 Laura Lasagni, Maria Lucia Angelotti, Elisa Ronconi, Duccio Lombardi, Sara Nardi, Anna Peired, Francesca Becherucci, Benedetta Mazzinghi, Alessandro Sisti, Simone Romoli, Alexa Burger, Beat Schaefer, Annamaria Buccoliero, Elena Lazzeri, Paola Romagnani
Podocyte Regeneration Driven by Renal Progenitors Determines Glomerular Disease Remission and Can Be Pharmacologically Enhanced
published pages: 248-263, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2015.07.003
Stem Cell Reports 5/2 2019-06-06
2017 Paola Romagnani, Giuseppe Remuzzi, Richard Glassock, Adeera Levin, Kitty J. Jager, Marcello Tonelli, Ziad Massy, Christoph Wanner, Hans-Joachim Anders
Chronic kidney disease
published pages: 17088, ISSN: 2056-676X, DOI: 10.1038/nrdp.2017.88
Nature Reviews Disease Primers 3 2019-06-06
2016 Paola Romagnani, Sabrina Giglio, Maria Lucia Angelotti, Aldesia Provenzano, Francesca Becherucci, Benedetta Mazzinghi, Susanna Müller, Kerstin Amann, Marc Weidenbusch, Simone Romoli, Elena Lazzeri, Hans-Joachim Anders
Next generation sequencing and functional analysis of patient urine renal progenitor-derived podocytes to unravel the diagnosis underlying refractory lupus nephritis
published pages: 1541-1545, ISSN: 0931-0509, DOI: 10.1093/ndt/gfw234
Nephrology Dialysis Transplantation 31/9 2019-06-06
2016 Duccio Lombardi, Francesca Becherucci, Paola Romagnani
How much can the tubule regenerate and who does it? An open question.
published pages: 1243-1250, ISSN: 1460-2385, DOI: 10.1093/ndt/gfv262
Nephrol Dial Transplant 31/8 2019-06-06
2015 Elena Lazzeri, Paola Romagnani, Laura Lasagni
Stem cell therapy for kidney disease
published pages: 1455-1468, ISSN: 1471-2598, DOI: 10.1517/14712598.2015.1067300
Expert Opinion on Biological Therapy 15/10 2019-06-06
2018 Marco Allinovi, Letizia De Chiara, Maria Lucia Angelotti, Francesca Becherucci, Paola Romagnani
Anti-fibrotic treatments: A review of clinical evidence
published pages: 333-354, ISSN: 0945-053X, DOI: 10.1016/j.matbio.2018.02.017
Matrix Biology 68-69 2019-06-06
2018 Simone Romoli, Maria Lucia Angelotti, Maria Lucia Angelotti, Giulia Antonelli, Santhosh Kumar VR, Shrikant R. Mulay, Jyaysi Desai, Lidia Anguiano Gomez, Dana Thomasova, Dirk Eulberg, Sven Klussmann, Maria Elena Melica, Carolina Conte, Duccio Lombardi, Laura Lasagni, Hans-Joachim Anders, Paola Romagnani
3D and STED microscopy identify CXCL12 blockade to regenerate lost podocytes preferentially in cortical rather than juxtamedullary nephrons by targeting an intrinsic podocyte-progenitor feedback mechanism
published pages: , ISSN: 0085-2538, DOI:
Kidney International 2019-06-06

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