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RENOIR SIGNED

RENal prOgenItoRs as tools to understand kidney pathophysiology and treat kidney disorders

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

RENOIR project word cloud

Explore the words cloud of the RENOIR project. It provides you a very rough idea of what is the project "RENOIR" about.

player replacement pathogenesis nephron perspective models aging regard carcinoma characterization niche treatment evaluation kidney adult toxicity innovative homeostasis mouse lineage limited modifying drug life isolation culturing progress therapeutic glomerular disorders personalized stages observation validate resolution progression abnormal disease patient injury performed rpc tissue tracing expand inaccessibility urine regression tools murine identification screening podocyte assays will global cell medicine compounds nephrology regeneration possibilities purposes culture strategies options renal opens mechanisms health function tubular issue modeling progenitors nephrotoxicity

Project "RENOIR" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA DEGLI STUDI DI FIRENZE Organization address address: Piazza San Marco 4 city: Florence postcode: 50121 website: http://www.unifi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.renalprogenitorsflorence.com
Total cost	1˙772˙718 €
EC max contribution	1˙772˙718 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2015
Duration (year-month-day)	from 2015-07-01 to 2020-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI FIRENZE UNIVERSITA DEGLI STUDI DI FIRENZE Organization address address: Piazza San Marco 4 city: Florence postcode: 50121 website: http://www.unifi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (Florence)	coordinator	1˙772˙718.00

Map

Project objective

Kidney disorders represent a major global health issue and new tools are needed to expand disease modeling and therapeutic options. The identification of renal progenitors (RPC) opens a wide range of possibilities to support progress in several fields of nephrology. Indeed, RPC have become a key player in the pathogenesis of kidney disorders, and their study is increasing knowledge about the mechanisms of kidney response to injury. In this project we propose new lineage tracing models to identify and characterize mouse RPC system. We then will use these models to establish RPC role in progression or resolution of glomerular and tubular injury, and the mechanisms involved in these processes. Furthermore, the role of abnormal RPC function in the pathogenesis of renal cell carcinoma will be established. We will proceed to validate RPC as therapeutic targets to improve podocyte regeneration and disease regression. Lineage tracing of the murine RPC system from development to adult life and characterization of the RPC niche will be performed through observation of RPC at various stages of nephron formation during development as well as during kidney growth, homeostasis and aging. RPC isolation and culture from kidney tissue being limited due to their inaccessibility, the recent development of a method for culturing them specifically from urine finally opens the perspective of personalized medicine of the kidney and the development of patient-specific treatment strategies. In addition, patient-specific RPC can be useful for screening of new drug compounds, developing disease-modifying assays, as well as for evaluation of drug toxicity, with particular regard to nephrotoxicity. Finally, RPC represent potential tools and/or targets for therapeutic purposes and to promote innovative renal replacement strategies for kidney disorders.

Publications

List of publications.
year	authors and title	journal	last update
2019	Maria Elena Melica, Gilda La Regina, Matteo Parri, Anna Julie Peired, Paola Romagnani, Laura Lasagni Substrate Stiffness Modulates Renal Progenitor Cell Properties via a ROCK-Mediated Mechanotransduction Mechanism published pages: 1561, ISSN: 2073-4409, DOI: 10.3390/cells8121561	Cells 8/12	2020-02-28
2019	Maria Lucia Angelotti, Giulia Antonelli, Carolina Conte, Paola Romagnani Imaging the kidney: from light to super-resolution microscopy published pages: , ISSN: 0931-0509, DOI: 10.1093/ndt/gfz136	Nephrology Dialysis Transplantation	2020-02-28
2019	Elena Lazzeri, Maria Lucia Angelotti, Carolina Conte, Hans-Joachim Anders, Paola Romagnani Surviving Acute Organ Failure: Cell Polyploidization and Progenitor Proliferation published pages: 366-381, ISSN: 1471-4914, DOI: 10.1016/j.molmed.2019.02.006	Trends in Molecular Medicine 25/5	2020-02-28
2019	Francesco Guzzi, Luigi Cirillo, Rosa Maria Roperto, Paola Romagnani, Elena Lazzeri Molecular Mechanisms of the Acute Kidney Injury to Chronic Kidney Disease Transition: An Updated View published pages: 4941, ISSN: 1422-0067, DOI: 10.3390/ijms20194941	International Journal of Molecular Sciences 20/19	2020-02-28
2018	Elena Lazzeri, Maria Lucia Angelotti, Anna Peired, Carolina Conte, Julian A. Marschner, Laura Maggi, Benedetta Mazzinghi, Duccio Lombardi, Maria Elena Melica, Sara Nardi, Elisa Ronconi, Alessandro Sisti, Giulia Antonelli, Francesca Becherucci, Letizia De Chiara, Ricardo Romero Guevara, Alexa Burger, Beat Schaefer, Francesco Annunziato, Hans-Joachim Anders, Laura Lasagni, Paola Romagnani Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03753-4	Nature Communications 9/1	2019-06-06
2015	Laura Lasagni, MariaÂ Lucia Angelotti, Elisa Ronconi, Duccio Lombardi, Sara Nardi, Anna Peired, Francesca Becherucci, Benedetta Mazzinghi, Alessandro Sisti, Simone Romoli, Alexa Burger, Beat Schaefer, Annamaria Buccoliero, Elena Lazzeri, Paola Romagnani Podocyte Regeneration Driven by Renal Progenitors Determines Glomerular Disease Remission and Can Be Pharmacologically Enhanced published pages: 248-263, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2015.07.003	Stem Cell Reports 5/2	2019-06-06
2017	Paola Romagnani, Giuseppe Remuzzi, Richard Glassock, Adeera Levin, Kitty J. Jager, Marcello Tonelli, Ziad Massy, Christoph Wanner, Hans-Joachim Anders Chronic kidney disease published pages: 17088, ISSN: 2056-676X, DOI: 10.1038/nrdp.2017.88	Nature Reviews Disease Primers 3	2019-06-06
2016	Paola Romagnani, Sabrina Giglio, Maria Lucia Angelotti, Aldesia Provenzano, Francesca Becherucci, Benedetta Mazzinghi, Susanna MÃ¼ller, Kerstin Amann, Marc Weidenbusch, Simone Romoli, Elena Lazzeri, Hans-Joachim Anders Next generation sequencing and functional analysis of patient urine renal progenitor-derived podocytes to unravel the diagnosis underlying refractory lupus nephritis published pages: 1541-1545, ISSN: 0931-0509, DOI: 10.1093/ndt/gfw234	Nephrology Dialysis Transplantation 31/9	2019-06-06
2016	Duccio Lombardi, Francesca Becherucci, Paola Romagnani How much can the tubule regenerate and who does it? An open question. published pages: 1243-1250, ISSN: 1460-2385, DOI: 10.1093/ndt/gfv262	Nephrol Dial Transplant 31/8	2019-06-06
2015	Elena Lazzeri, Paola Romagnani, Laura Lasagni Stem cell therapy for kidney disease published pages: 1455-1468, ISSN: 1471-2598, DOI: 10.1517/14712598.2015.1067300	Expert Opinion on Biological Therapy 15/10	2019-06-06
2018	Marco Allinovi, Letizia De Chiara, Maria Lucia Angelotti, Francesca Becherucci, Paola Romagnani Anti-fibrotic treatments: A review of clinical evidence published pages: 333-354, ISSN: 0945-053X, DOI: 10.1016/j.matbio.2018.02.017	Matrix Biology 68-69	2019-06-06
2018	Simone Romoli, Maria Lucia Angelotti, Maria Lucia Angelotti, Giulia Antonelli, Santhosh Kumar VR, Shrikant R. Mulay, Jyaysi Desai, Lidia Anguiano Gomez, Dana Thomasova, Dirk Eulberg, Sven Klussmann, Maria Elena Melica, Carolina Conte, Duccio Lombardi, Laura Lasagni, Hans-Joachim Anders, Paola Romagnani 3D and STED microscopy identify CXCL12 blockade to regenerate lost podocytes preferentially in cortical rather than juxtamedullary nephrons by targeting an intrinsic podocyte-progenitor feedback mechanism published pages: , ISSN: 0085-2538, DOI:	Kidney International	2019-06-06

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