Explore the words cloud of the Virocellsphere project. It provides you a very rough idea of what is the project "Virocellsphere" about.
The following table provides information about the project.
WEIZMANN INSTITUTE OF SCIENCE
|Coordinator Country||Israel [IL]|
|Total cost||2˙749˙901 €|
|EC max contribution||2˙749˙901 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-11-01 to 2021-10-31|
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|1||WEIZMANN INSTITUTE OF SCIENCE||IL (REHOVOT)||coordinator||2˙749˙901.00|
Phytoplankton blooms are ephemeral events of exceptionally high primary productivity that regulate the flux of carbon across marine food webs. The cosmopolitan coccolithophore Emiliania huxleyi (Haptophyta) is a unicellular eukaryotic alga responsible for the largest oceanic algal blooms covering thousands of square kilometers. These annual blooms are frequently terminated by a specific large dsDNA E. huxleyi virus (EhV). Despite the huge ecological importance of host-virus interactions, the ability to assess their ecological impact is limited to current approaches, which focus mainly on quantification of viral abundance and diversity. On the molecular basis, a major challenge in the current understanding of host-virus interactions in the marine environment is the ability to decode the wealth of “omics” data and translate it into cellular mechanisms that mediate host susceptibility and resistance to viral infection. In the current proposal we intend to provide novel functional insights into molecular mechanisms that regulate host-virus interactions at the single-cell level by unravelling phenotypic heterogeneity within infected populations. By using physiological markers and single-cell transcriptomics, we propose to discern between host subpopulations and define their different “metabolic states”, in order to map them into different modes of susceptibility and resistance. By using advanced metabolomic approaches, we also aim to define the infochemical microenvironment generated during viral infection and examine how it can shape host phenotypic plasticity. Mapping the transcriptomic and metabolic footprints of viral infection will provide a meaningful tool to assess the dynamics of active viral infection during natural E. huxleyi blooms. Our novel approaches will pave the way for unprecedented quantification of the “viral shunt” that drives nutrient fluxes in marine food webs, from a single-cell level to a population and eventually ecosystem levels.
|year||authors and title||journal||last update|
Shilo Rosenwasser, Uri Sheyn, Miguel J. Frada, David Pilzer, Ron Rotkopf, Assaf Vardi
Unmasking cellular response of a bloom-forming alga to viral infection by resolving expression profiles at a single-cell level
published pages: e1007708, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007708
|PLOS Pathogens 15/4||2019-08-05|
Guy Schleyer, Nir Shahaf, Carmit Ziv, Yonghui Dong, Roy A. Meoded, Eric J. N. Helfrich, Daniella Schatz, Shilo Rosenwasser, Ilana Rogachev, Asaph Aharoni, JÃ¶rn Piel, Assaf Vardi
In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids
published pages: 527-538, ISSN: 2058-5276, DOI: 10.1038/s41564-018-0336-y
|Nature Microbiology 4/3||2019-08-05|
Noa Barak-Gavish, Miguel JosÃ© Frada, Chuan Ku, Peter A. Lee, Giacomo R. DiTullio, Sergey Malitsky, Asaph Aharoni, Stefan J. Green, Ron Rotkopf, Elena Kartvelishvily, Uri Sheyn, Daniella Schatz, Assaf Vardi
Bacterial virulence against an oceanic bloom-forming phytoplankter is mediated by algal DMSP
published pages: eaau5716, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau5716
|Science Advances 4/10||2019-08-05|
Uri Sheyn, Shilo Rosenwasser, Yoav Lehahn, Noa Barak-Gavish, Ron Rotkopf, Kay D. Bidle, Ilan Koren, Daniella Schatz, Assaf Vardi
Expression profiling of host and virus during a coccolithophore bloom provides insights into the role of viral infection in promoting carbon export
published pages: 704-713, ISSN: 1751-7362, DOI: 10.1038/s41396-017-0004-x
|The ISME Journal 12/3||2019-06-18|
Daniella Schatz, Assaf Vardi
Extracellular vesicles â€” new players in cellâ€“cell communication in aquatic environments
published pages: 148-154, ISSN: 1369-5274, DOI: 10.1016/j.mib.2018.01.014
|Current Opinion in Microbiology 43||2019-06-18|
Daniella Schatz, Shilo Rosenwasser, Sergey Malitsky, Sharon G. Wolf, Ester Feldmesser, Assaf Vardi
Communication via extracellular vesicles enhances viral infection of a cosmopolitan alga
published pages: 1485-1492, ISSN: 2058-5276, DOI: 10.1038/s41564-017-0024-3
|Nature Microbiology 2/11||2019-06-18|
Miguel JosÃ© Frada, Shilo Rosenwasser, Shifra Ben-Dor, Adva Shemi, Helena Sabanay, Assaf Vardi
Morphological switch to a resistant subpopulation in response to viral infection in the bloom-forming coccolithophore Emiliania huxleyi
published pages: e1006775, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1006775
|PLOS Pathogens 13/12||2019-06-18|
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