Opendata, web and dolomites

Virocellsphere SIGNED

Host-virus chemical arms race during algal bloom in the ocean at a single cell resolution

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Virocellsphere project word cloud

Explore the words cloud of the Virocellsphere project. It provides you a very rough idea of what is the project "Virocellsphere" about.

ehv    webs    metabolomic    algal    alga    populations    natural    plasticity    drives    shunt    oceanic    translate    omics    abundance    resistance    examine    shape    microenvironment    limited    cellular    virus    markers    intend    molecular    map    active    huxleyi    unravelling    footprints    square    exceptionally    mainly    transcriptomics    huge    mechanisms    decode    food    infected    fluxes    viral    environment    quantification    terminated    flux    wealth    phenotypic    tool    phytoplankton    mediate    population    frequently    responsible    infection    basis    nutrient    kilometers    functional    ecological    eukaryotic    annual    coccolithophore    infochemical    modes    insights    blooms    carbon    mapping    data    single    unprecedented    ecosystem    discern    unicellular    levels    metabolic    marine    diversity    pave    haptophyta    host    regulate    transcriptomic    ephemeral    despite    dynamics    thousands    subpopulations    primary    cell    productivity    events    susceptibility    cosmopolitan    physiological    emiliania    heterogeneity    interactions    dsdna   

Project "Virocellsphere" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website http://www.weizmann.ac.il/plants/vardi/
 Total cost 2˙749˙901 €
 EC max contribution 2˙749˙901 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙749˙901.00

Map

 Project objective

Phytoplankton blooms are ephemeral events of exceptionally high primary productivity that regulate the flux of carbon across marine food webs. The cosmopolitan coccolithophore Emiliania huxleyi (Haptophyta) is a unicellular eukaryotic alga responsible for the largest oceanic algal blooms covering thousands of square kilometers. These annual blooms are frequently terminated by a specific large dsDNA E. huxleyi virus (EhV). Despite the huge ecological importance of host-virus interactions, the ability to assess their ecological impact is limited to current approaches, which focus mainly on quantification of viral abundance and diversity. On the molecular basis, a major challenge in the current understanding of host-virus interactions in the marine environment is the ability to decode the wealth of “omics” data and translate it into cellular mechanisms that mediate host susceptibility and resistance to viral infection. In the current proposal we intend to provide novel functional insights into molecular mechanisms that regulate host-virus interactions at the single-cell level by unravelling phenotypic heterogeneity within infected populations. By using physiological markers and single-cell transcriptomics, we propose to discern between host subpopulations and define their different “metabolic states”, in order to map them into different modes of susceptibility and resistance. By using advanced metabolomic approaches, we also aim to define the infochemical microenvironment generated during viral infection and examine how it can shape host phenotypic plasticity. Mapping the transcriptomic and metabolic footprints of viral infection will provide a meaningful tool to assess the dynamics of active viral infection during natural E. huxleyi blooms. Our novel approaches will pave the way for unprecedented quantification of the “viral shunt” that drives nutrient fluxes in marine food webs, from a single-cell level to a population and eventually ecosystem levels.

 Publications

year authors and title journal last update
List of publications.
2019 Shilo Rosenwasser, Uri Sheyn, Miguel J. Frada, David Pilzer, Ron Rotkopf, Assaf Vardi
Unmasking cellular response of a bloom-forming alga to viral infection by resolving expression profiles at a single-cell level
published pages: e1007708, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007708
PLOS Pathogens 15/4 2019-08-05
2019 Guy Schleyer, Nir Shahaf, Carmit Ziv, Yonghui Dong, Roy A. Meoded, Eric J. N. Helfrich, Daniella Schatz, Shilo Rosenwasser, Ilana Rogachev, Asaph Aharoni, Jörn Piel, Assaf Vardi
In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids
published pages: 527-538, ISSN: 2058-5276, DOI: 10.1038/s41564-018-0336-y
Nature Microbiology 4/3 2019-08-05
2018 Noa Barak-Gavish, Miguel José Frada, Chuan Ku, Peter A. Lee, Giacomo R. DiTullio, Sergey Malitsky, Asaph Aharoni, Stefan J. Green, Ron Rotkopf, Elena Kartvelishvily, Uri Sheyn, Daniella Schatz, Assaf Vardi
Bacterial virulence against an oceanic bloom-forming phytoplankter is mediated by algal DMSP
published pages: eaau5716, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau5716
Science Advances 4/10 2019-08-05
2018 Uri Sheyn, Shilo Rosenwasser, Yoav Lehahn, Noa Barak-Gavish, Ron Rotkopf, Kay D. Bidle, Ilan Koren, Daniella Schatz, Assaf Vardi
Expression profiling of host and virus during a coccolithophore bloom provides insights into the role of viral infection in promoting carbon export
published pages: 704-713, ISSN: 1751-7362, DOI: 10.1038/s41396-017-0004-x
The ISME Journal 12/3 2019-06-18
2018 Daniella Schatz, Assaf Vardi
Extracellular vesicles — new players in cell–cell communication in aquatic environments
published pages: 148-154, ISSN: 1369-5274, DOI: 10.1016/j.mib.2018.01.014
Current Opinion in Microbiology 43 2019-06-18
2017 Daniella Schatz, Shilo Rosenwasser, Sergey Malitsky, Sharon G. Wolf, Ester Feldmesser, Assaf Vardi
Communication via extracellular vesicles enhances viral infection of a cosmopolitan alga
published pages: 1485-1492, ISSN: 2058-5276, DOI: 10.1038/s41564-017-0024-3
Nature Microbiology 2/11 2019-06-18
2017 Miguel José Frada, Shilo Rosenwasser, Shifra Ben-Dor, Adva Shemi, Helena Sabanay, Assaf Vardi
Morphological switch to a resistant subpopulation in response to viral infection in the bloom-forming coccolithophore Emiliania huxleyi
published pages: e1006775, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1006775
PLOS Pathogens 13/12 2019-06-18

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "VIROCELLSPHERE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "VIROCELLSPHERE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

E-DIRECT (2020)

Evolution of Direct Reciprocity in Complex Environments

Read More  

AllergenDetect (2019)

Comprehensive allergen detection using synthetic DNA libraries

Read More  

inhibiTOR (2020)

Novel selective mTORC1 inhibitors

Read More