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Virocellsphere SIGNED

Host-virus chemical arms race during algal bloom in the ocean at a single cell resolution

Total Cost €

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EC-Contrib. €

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Partnership

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 Virocellsphere project word cloud

Explore the words cloud of the Virocellsphere project. It provides you a very rough idea of what is the project "Virocellsphere" about.

thousands    decode    markers    productivity    shunt    exceptionally    cell    wealth    blooms    diversity    viral    translate    phenotypic    footprints    host    limited    infochemical    marine    microenvironment    natural    discern    fluxes    unprecedented    webs    levels    map    algal    single    quantification    examine    alga    infection    unravelling    intend    carbon    eukaryotic    mechanisms    events    huge    dynamics    pave    functional    molecular    despite    mediate    cellular    infected    frequently    ehv    nutrient    terminated    kilometers    environment    resistance    active    square    plasticity    mapping    data    heterogeneity    basis    flux    transcriptomics    transcriptomic    dsdna    ecosystem    population    ephemeral    metabolic    tool    mainly    ecological    regulate    primary    cosmopolitan    haptophyta    modes    shape    unicellular    subpopulations    huxleyi    phytoplankton    abundance    emiliania    food    omics    oceanic    drives    annual    coccolithophore    virus    insights    metabolomic    interactions    physiological    populations    responsible    susceptibility   

Project "Virocellsphere" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Israel [IL]
 Project website http://www.weizmann.ac.il/plants/vardi/
 Total cost 2˙749˙901 €
 EC max contribution 2˙749˙901 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙749˙901.00

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 Project objective

Phytoplankton blooms are ephemeral events of exceptionally high primary productivity that regulate the flux of carbon across marine food webs. The cosmopolitan coccolithophore Emiliania huxleyi (Haptophyta) is a unicellular eukaryotic alga responsible for the largest oceanic algal blooms covering thousands of square kilometers. These annual blooms are frequently terminated by a specific large dsDNA E. huxleyi virus (EhV). Despite the huge ecological importance of host-virus interactions, the ability to assess their ecological impact is limited to current approaches, which focus mainly on quantification of viral abundance and diversity. On the molecular basis, a major challenge in the current understanding of host-virus interactions in the marine environment is the ability to decode the wealth of “omics” data and translate it into cellular mechanisms that mediate host susceptibility and resistance to viral infection. In the current proposal we intend to provide novel functional insights into molecular mechanisms that regulate host-virus interactions at the single-cell level by unravelling phenotypic heterogeneity within infected populations. By using physiological markers and single-cell transcriptomics, we propose to discern between host subpopulations and define their different “metabolic states”, in order to map them into different modes of susceptibility and resistance. By using advanced metabolomic approaches, we also aim to define the infochemical microenvironment generated during viral infection and examine how it can shape host phenotypic plasticity. Mapping the transcriptomic and metabolic footprints of viral infection will provide a meaningful tool to assess the dynamics of active viral infection during natural E. huxleyi blooms. Our novel approaches will pave the way for unprecedented quantification of the “viral shunt” that drives nutrient fluxes in marine food webs, from a single-cell level to a population and eventually ecosystem levels.

 Publications

year authors and title journal last update
List of publications.
2019 Shilo Rosenwasser, Uri Sheyn, Miguel J. Frada, David Pilzer, Ron Rotkopf, Assaf Vardi
Unmasking cellular response of a bloom-forming alga to viral infection by resolving expression profiles at a single-cell level
published pages: e1007708, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007708
PLOS Pathogens 15/4 2019-08-05
2019 Guy Schleyer, Nir Shahaf, Carmit Ziv, Yonghui Dong, Roy A. Meoded, Eric J. N. Helfrich, Daniella Schatz, Shilo Rosenwasser, Ilana Rogachev, Asaph Aharoni, Jörn Piel, Assaf Vardi
In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids
published pages: 527-538, ISSN: 2058-5276, DOI: 10.1038/s41564-018-0336-y
Nature Microbiology 4/3 2019-08-05
2018 Noa Barak-Gavish, Miguel José Frada, Chuan Ku, Peter A. Lee, Giacomo R. DiTullio, Sergey Malitsky, Asaph Aharoni, Stefan J. Green, Ron Rotkopf, Elena Kartvelishvily, Uri Sheyn, Daniella Schatz, Assaf Vardi
Bacterial virulence against an oceanic bloom-forming phytoplankter is mediated by algal DMSP
published pages: eaau5716, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau5716
Science Advances 4/10 2019-08-05
2018 Uri Sheyn, Shilo Rosenwasser, Yoav Lehahn, Noa Barak-Gavish, Ron Rotkopf, Kay D. Bidle, Ilan Koren, Daniella Schatz, Assaf Vardi
Expression profiling of host and virus during a coccolithophore bloom provides insights into the role of viral infection in promoting carbon export
published pages: 704-713, ISSN: 1751-7362, DOI: 10.1038/s41396-017-0004-x
The ISME Journal 12/3 2019-06-18
2018 Daniella Schatz, Assaf Vardi
Extracellular vesicles — new players in cell–cell communication in aquatic environments
published pages: 148-154, ISSN: 1369-5274, DOI: 10.1016/j.mib.2018.01.014
Current Opinion in Microbiology 43 2019-06-18
2017 Daniella Schatz, Shilo Rosenwasser, Sergey Malitsky, Sharon G. Wolf, Ester Feldmesser, Assaf Vardi
Communication via extracellular vesicles enhances viral infection of a cosmopolitan alga
published pages: 1485-1492, ISSN: 2058-5276, DOI: 10.1038/s41564-017-0024-3
Nature Microbiology 2/11 2019-06-18
2017 Miguel José Frada, Shilo Rosenwasser, Shifra Ben-Dor, Adva Shemi, Helena Sabanay, Assaf Vardi
Morphological switch to a resistant subpopulation in response to viral infection in the bloom-forming coccolithophore Emiliania huxleyi
published pages: e1006775, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1006775
PLOS Pathogens 13/12 2019-06-18

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