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Virocellsphere SIGNED

Host-virus chemical arms race during algal bloom in the ocean at a single cell resolution

Total Cost €

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EC-Contrib. €

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Partnership

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 Virocellsphere project word cloud

Explore the words cloud of the Virocellsphere project. It provides you a very rough idea of what is the project "Virocellsphere" about.

haptophyta    nutrient    infection    molecular    phytoplankton    functional    despite    cell    thousands    limited    intend    resistance    metabolic    frequently    environment    examine    ecosystem    subpopulations    basis    huxleyi    viral    dsdna    wealth    susceptibility    data    footprints    mapping    infected    eukaryotic    terminated    diversity    omics    unprecedented    drives    productivity    alga    metabolomic    unicellular    oceanic    fluxes    ecological    infochemical    mediate    translate    events    mechanisms    natural    cellular    quantification    mainly    huge    plasticity    discern    primary    modes    dynamics    food    exceptionally    marine    cosmopolitan    tool    populations    decode    host    flux    microenvironment    markers    ehv    annual    shunt    physiological    square    shape    abundance    interactions    coccolithophore    transcriptomic    virus    transcriptomics    carbon    algal    unravelling    map    phenotypic    responsible    active    blooms    single    ephemeral    population    insights    webs    heterogeneity    levels    regulate    kilometers    pave    emiliania   

Project "Virocellsphere" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website http://www.weizmann.ac.il/plants/vardi/
 Total cost 2˙749˙901 €
 EC max contribution 2˙749˙901 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙749˙901.00

Map

 Project objective

Phytoplankton blooms are ephemeral events of exceptionally high primary productivity that regulate the flux of carbon across marine food webs. The cosmopolitan coccolithophore Emiliania huxleyi (Haptophyta) is a unicellular eukaryotic alga responsible for the largest oceanic algal blooms covering thousands of square kilometers. These annual blooms are frequently terminated by a specific large dsDNA E. huxleyi virus (EhV). Despite the huge ecological importance of host-virus interactions, the ability to assess their ecological impact is limited to current approaches, which focus mainly on quantification of viral abundance and diversity. On the molecular basis, a major challenge in the current understanding of host-virus interactions in the marine environment is the ability to decode the wealth of “omics” data and translate it into cellular mechanisms that mediate host susceptibility and resistance to viral infection. In the current proposal we intend to provide novel functional insights into molecular mechanisms that regulate host-virus interactions at the single-cell level by unravelling phenotypic heterogeneity within infected populations. By using physiological markers and single-cell transcriptomics, we propose to discern between host subpopulations and define their different “metabolic states”, in order to map them into different modes of susceptibility and resistance. By using advanced metabolomic approaches, we also aim to define the infochemical microenvironment generated during viral infection and examine how it can shape host phenotypic plasticity. Mapping the transcriptomic and metabolic footprints of viral infection will provide a meaningful tool to assess the dynamics of active viral infection during natural E. huxleyi blooms. Our novel approaches will pave the way for unprecedented quantification of the “viral shunt” that drives nutrient fluxes in marine food webs, from a single-cell level to a population and eventually ecosystem levels.

 Publications

year authors and title journal last update
List of publications.
2019 Shilo Rosenwasser, Uri Sheyn, Miguel J. Frada, David Pilzer, Ron Rotkopf, Assaf Vardi
Unmasking cellular response of a bloom-forming alga to viral infection by resolving expression profiles at a single-cell level
published pages: e1007708, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007708
PLOS Pathogens 15/4 2019-08-05
2019 Guy Schleyer, Nir Shahaf, Carmit Ziv, Yonghui Dong, Roy A. Meoded, Eric J. N. Helfrich, Daniella Schatz, Shilo Rosenwasser, Ilana Rogachev, Asaph Aharoni, Jörn Piel, Assaf Vardi
In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids
published pages: 527-538, ISSN: 2058-5276, DOI: 10.1038/s41564-018-0336-y
Nature Microbiology 4/3 2019-08-05
2018 Noa Barak-Gavish, Miguel José Frada, Chuan Ku, Peter A. Lee, Giacomo R. DiTullio, Sergey Malitsky, Asaph Aharoni, Stefan J. Green, Ron Rotkopf, Elena Kartvelishvily, Uri Sheyn, Daniella Schatz, Assaf Vardi
Bacterial virulence against an oceanic bloom-forming phytoplankter is mediated by algal DMSP
published pages: eaau5716, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau5716
Science Advances 4/10 2019-08-05
2018 Uri Sheyn, Shilo Rosenwasser, Yoav Lehahn, Noa Barak-Gavish, Ron Rotkopf, Kay D. Bidle, Ilan Koren, Daniella Schatz, Assaf Vardi
Expression profiling of host and virus during a coccolithophore bloom provides insights into the role of viral infection in promoting carbon export
published pages: 704-713, ISSN: 1751-7362, DOI: 10.1038/s41396-017-0004-x
The ISME Journal 12/3 2019-06-18
2018 Daniella Schatz, Assaf Vardi
Extracellular vesicles — new players in cell–cell communication in aquatic environments
published pages: 148-154, ISSN: 1369-5274, DOI: 10.1016/j.mib.2018.01.014
Current Opinion in Microbiology 43 2019-06-18
2017 Daniella Schatz, Shilo Rosenwasser, Sergey Malitsky, Sharon G. Wolf, Ester Feldmesser, Assaf Vardi
Communication via extracellular vesicles enhances viral infection of a cosmopolitan alga
published pages: 1485-1492, ISSN: 2058-5276, DOI: 10.1038/s41564-017-0024-3
Nature Microbiology 2/11 2019-06-18
2017 Miguel José Frada, Shilo Rosenwasser, Shifra Ben-Dor, Adva Shemi, Helena Sabanay, Assaf Vardi
Morphological switch to a resistant subpopulation in response to viral infection in the bloom-forming coccolithophore Emiliania huxleyi
published pages: e1006775, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1006775
PLOS Pathogens 13/12 2019-06-18

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