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CD4DNASP SIGNED

Cell intrinsic control of CD4 T cell differentiation by cytosolic DNA sensing pathways

Total Cost €

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EC-Contrib. €

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Partnership

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Project "CD4DNASP" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙500˙000.00

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 Project objective

This proposal aims to investigate the role of cytosolic DNA sensing pathways in CD4 T cell differentiation. Cellular host defense to pathogens relies on the detection of pathogen-associated molecular patterns including deoxyribonucleic acid (DNA), which can be recognized by host myeloid cells through Toll-like receptor (TLR) 9 binding. Recent evidence however suggests that innate immune cells can also perceive cytoplasmic DNA from infectious or autologous origin through cytosolic DNA sensors triggering TLR9-independent signaling. Activation of cytosolic DNA sensor-dependent signaling pathways has been clearly shown to trigger innate immune responses to microbial and host DNA, but the contribution of cytosolic DNA sensors to the differentiation of CD4 T cells, an essential event for shaping adaptive immune responses, has not been documented. This proposal aims to fill this current knowledge gap. We aim to decipher the molecular series of transcriptional events triggered by DNA in CD4 T cells that ultimately result in altered T cell differentiation. This aim will be addressed by combining in vitro and in vivo approaches such as advanced gene expression analysis of CD4 T cells and use of transgenic and gene-deficient mice. Structure activity relationship and biophysical studies will also be performed to unravel novel immunomodulators able to affect CD4 T cell differentiation.

 Publications

year authors and title journal last update
List of publications.
2019 Thaiz Rivera Vargas, Lionel Apetoh
Can Immunogenic Chemotherapies Relieve Cancer Cell Resistance to Immune Checkpoint Inhibitors?
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01181
Frontiers in Immunology 10 2019-10-03
2017 Thaiz Rivera Vargas, Zhijian Cai, Yingying Shen, Magalie Dosset, Isis Benoit-Lizon, Tiffany Martin, Aurélie Roussey, Richard A. Flavell, François Ghiringhelli, Lionel Apetoh
Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00468-w
Nature Communications 8/1 2019-07-08
2017 Muhammet F. Gulen, Ute Koch, Simone M. Haag, Fabian Schuler, Lionel Apetoh, Andreas Villunger, Freddy Radtke, Andrea Ablasser
Signalling strength determines proapoptotic functions of STING
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00573-w
Nature Communications 8/1 2019-07-08
2017 Thaiz Rivera Vargas, Etienne Humblin, Frédérique Végran, François Ghiringhelli, Lionel Apetoh
TH9 cells in anti-tumor immunity
published pages: 39-46, ISSN: 1863-2297, DOI: 10.1007/s00281-016-0599-4
Seminars in Immunopathology 39/1 2019-07-08
2017 Carole Fournier, Thaiz Rivera Vargas, Tiffany Martin, Andréa Melis, Lionel Apetoh
Immunotherapeutic properties of chemotherapy
published pages: 83-88, ISSN: 1471-4892, DOI: 10.1016/j.coph.2017.05.003
Current Opinion in Pharmacology 35 2019-05-22
2019 Peng Liu, Liwei Zhao, Jonathan Pol, Sarah Levesque, Adriana Petrazzuolo, Christina Pfirschke, Camilla Engblom, Steffen Rickelt, Takahiro Yamazaki, Kristina Iribarren, Laura Senovilla, Lucillia Bezu, Erika Vacchelli, Valentina Sica, Andréa Melis, Tiffany Martin, Xia Lin, Heng Yang, Qingqing Li, Jinfeng Chen, Sylvère Durand, Fanny Aprahamian, Deborah Lefevre, Sophie Broutin, Angelo Paci, Amaury Bongers, Veronique Minard-Colin, Eric Tartour, Laurence Zitvogel, Lionel Apetoh, Yuting Ma, Mikael J. Pittet, Oliver Kepp, Guido Kroemer
Crizotinib-induced immunogenic cell death in non-small cell lung cancer
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09415-3
Nature Communications 10/1 2019-05-22
2017 Thaiz Rivera Vargas, Lionel Apetoh
Danger signals: Chemotherapy enhancers?
published pages: 175-193, ISSN: 0105-2896, DOI: 10.1111/imr.12581
Immunological Reviews 280/1 2019-05-22
2017 Thaiz Rivera Vargas, François Martin, Lionel Apetoh
Role of interleukin-1-family cytokines on effector CD4 T cell differentiation
published pages: 24, ISSN: 2219-2824, DOI: 10.5411/wji.v7.i2.24
World Journal of Immunology 7/2 2019-05-22
2017 Thaiz Rivera Vargas, Isis Benoit-Lizon, Lionel Apetoh
Rationale for stimulator of interferon genes–targeted cancer immunotherapy
published pages: 86-97, ISSN: 0959-8049, DOI: 10.1016/j.ejca.2016.12.028
European Journal of Cancer 75 2019-04-14
2018 Elise Jacquin, Lionel Apetoh
Cell-Intrinsic Roles for Autophagy in Modulating CD4 T Cell Functions
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01023
Frontiers in Immunology 9 2019-04-14
2018 Magalie Dosset, Thaiz Rivera Vargas, Anaïs Lagrange, Romain Boidot, Frédérique Végran, Aurélie Roussey, Fanny Chalmin, Lucile Dondaine, Catherine Paul, Elodie Lauret Marie-Joseph, François Martin, Bernhard Ryffel, Christophe Borg, Olivier Adotévi, François Ghiringhelli, Lionel Apetoh
PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer
published pages: e1433981, ISSN: 2162-402X, DOI: 10.1080/2162402X.2018.1433981
OncoImmunology 7/6 2019-04-14

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