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PANDORA

Platelets: at the nexus of brain aneurysm

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Outcomes and results

 PANDORA project word cloud

Explore the words cloud of the PANDORA project. It provides you a very rough idea of what is the project "PANDORA" about.

maintenance    intervene    limited    haemorrhage    clipping    independently    roles    cell    therapeutic    carry    rupture    initially    smooth    microsurgical    ruptured    protection    platelets    brain    thrombo    window    cellular    function    inflammatory    devastating    protective    ia    potentially    despite    barrier    endothelial    form    thrombus    intracranial    unruptured    intervention    prevention    anti    deleterious    occurring    prevent    hypothesize    local    blood    muscle    subarachnoid    disease    situations    cross    procedural    pathogenesis    understand    hemorrhage    altered    options    clinical    interactions    later    events    leukocyte    risk    platelet    playing    talk    sah    mechanisms    treatment    cells    vascular    leukocytes    recruitment    plug    clots    invasive    types    70    therapies    25    linger    insults    integrity    evolution    intrasaccular    seems    pathophysiological    evolve    activated    efficient    inflammation    points    decipher    morbidity    aneurysm    aneurysms    forming    activation    endovascular   

Project "PANDORA" data sheet

The following table provides information about the project.

Coordinator		 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2018-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 173˙076.00

Map

 Project objective

Intracranial aneurysms (IA) with and without subarachnoid haemorrhage (SAH) linger as a potentially devastating clinical problem. Current therapeutic options are limited to invasive therapies, namely microsurgical clipping and endovascular treatment, both of which carry a significant risk of procedural morbidity. Increasing evidence points to inflammation as one of the leading factors in the pathogenesis of IA. Intrasaccular thrombus formation is a common feature of intracranial aneurysm occurring in 25% of unruptured and 70% of ruptured IA. In addition to forming clots, activated platelets support leukocyte recruitment. This cross-talk is a common feature in thrombo-inflammatory vascular disease. Despite these deleterious aspects of platelets, they also prevent local hemorrhage in inflammatory situations independently of their ability to form a platelet plug. The pathophysiological evolution of IA events seems driven by complex cellular interactions between different cell types including platelets, leukocytes and vascular cells (endothelial cells, smooth muscle cells). We hypothesize that the role of platelet roles may evolve throughout the development of IA: initially playing a protective role of in the maintenance of the blood brain barrier in response to inflammation and contributing later to intrasaccular thrombus formation. Therefore, altered platelet function may result in a loss of protection against vascular inflammatory insults. The main objective of this proposal is to better understand and decipher platelet mechanisms during IA formation and rupture. In this current application, we will (i) define platelet activation mechanisms in the development of IA and the impact on the blood-brain barrier integrity, (ii) test efficient anti-platelet therapies in the development and rupture of IA, (iii) define an efficient therapeutic window to intervene on platelet activation (prevention or intervention).

 Publications

year authors and title journal last update
List of publications.
2018 Yacine Boulaftali, Marie-Anne Mawhin, Martine Jandrot-Perrus, Benoît Ho-Tin-Noé
Glycoprotein VI in securing vascular integrity in inflamed vessels
published pages: 228-239, ISSN: 2475-0379, DOI: 10.1002/rth2.12092 		Research and Practice in Thrombosis and Haemostasis 2/2 2019-10-07
2017 Benoit Ho-Tin-Noé, Yacine Boulaftali, Eric Camerer
Platelets and vascular integrity: how platelets prevent bleeding in inflammation
published pages: blood-2017-06-74, ISSN: 0006-4971, DOI: 10.1182/blood-2017-06-742676 		Blood 2019-10-07

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The information about "PANDORA" are provided by the European Opendata Portal: CORDIS opendata.

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