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PANDORA

Platelets: at the nexus of brain aneurysm

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Outcomes and results

 PANDORA project word cloud

Explore the words cloud of the PANDORA project. It provides you a very rough idea of what is the project "PANDORA" about.

function    aneurysm    anti    procedural    muscle    seems    sah    microsurgical    mechanisms    brain    devastating    limited    playing    hypothesize    cell    hemorrhage    vascular    inflammatory    haemorrhage    thrombus    prevent    interactions    unruptured    occurring    linger    smooth    points    leukocytes    evolution    potentially    intervene    rupture    roles    deleterious    activated    clots    cellular    platelets    intervention    70    altered    initially    activation    pathophysiological    risk    decipher    prevention    disease    treatment    intracranial    25    integrity    recruitment    morbidity    evolve    maintenance    blood    form    cross    protection    talk    types    clipping    invasive    options    plug    subarachnoid    understand    leukocyte    despite    aneurysms    clinical    endovascular    local    platelet    pathogenesis    thrombo    events    endothelial    insults    cells    independently    therapeutic    ia    inflammation    barrier    ruptured    efficient    forming    situations    therapies    protective    carry    intrasaccular    later    window   

Project "PANDORA" data sheet

The following table provides information about the project.

Coordinator		 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2018-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 173˙076.00

Map

 Project objective

Intracranial aneurysms (IA) with and without subarachnoid haemorrhage (SAH) linger as a potentially devastating clinical problem. Current therapeutic options are limited to invasive therapies, namely microsurgical clipping and endovascular treatment, both of which carry a significant risk of procedural morbidity. Increasing evidence points to inflammation as one of the leading factors in the pathogenesis of IA. Intrasaccular thrombus formation is a common feature of intracranial aneurysm occurring in 25% of unruptured and 70% of ruptured IA. In addition to forming clots, activated platelets support leukocyte recruitment. This cross-talk is a common feature in thrombo-inflammatory vascular disease. Despite these deleterious aspects of platelets, they also prevent local hemorrhage in inflammatory situations independently of their ability to form a platelet plug. The pathophysiological evolution of IA events seems driven by complex cellular interactions between different cell types including platelets, leukocytes and vascular cells (endothelial cells, smooth muscle cells). We hypothesize that the role of platelet roles may evolve throughout the development of IA: initially playing a protective role of in the maintenance of the blood brain barrier in response to inflammation and contributing later to intrasaccular thrombus formation. Therefore, altered platelet function may result in a loss of protection against vascular inflammatory insults. The main objective of this proposal is to better understand and decipher platelet mechanisms during IA formation and rupture. In this current application, we will (i) define platelet activation mechanisms in the development of IA and the impact on the blood-brain barrier integrity, (ii) test efficient anti-platelet therapies in the development and rupture of IA, (iii) define an efficient therapeutic window to intervene on platelet activation (prevention or intervention).

 Publications

year authors and title journal last update
List of publications.
2018 Yacine Boulaftali, Marie-Anne Mawhin, Martine Jandrot-Perrus, Benoît Ho-Tin-Noé
Glycoprotein VI in securing vascular integrity in inflamed vessels
published pages: 228-239, ISSN: 2475-0379, DOI: 10.1002/rth2.12092 		Research and Practice in Thrombosis and Haemostasis 2/2 2019-10-07
2017 Benoit Ho-Tin-Noé, Yacine Boulaftali, Eric Camerer
Platelets and vascular integrity: how platelets prevent bleeding in inflammation
published pages: blood-2017-06-74, ISSN: 0006-4971, DOI: 10.1182/blood-2017-06-742676 		Blood 2019-10-07

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