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Platelets: at the nexus of brain aneurysm

Total Cost €


EC-Contrib. €






 PANDORA project word cloud

Explore the words cloud of the PANDORA project. It provides you a very rough idea of what is the project "PANDORA" about.

form    clinical    leukocytes    thrombo    types    muscle    aneurysm    subarachnoid    options    later    efficient    intrasaccular    25    seems    cells    prevention    initially    integrity    microsurgical    prevent    hypothesize    maintenance    inflammatory    vascular    therapies    cell    pathophysiological    intervene    anti    recruitment    talk    function    smooth    aneurysms    thrombus    activation    forming    sah    playing    platelet    cross    local    disease    unruptured    potentially    protection    endovascular    decipher    despite    intracranial    brain    carry    events    procedural    risk    invasive    evolution    treatment    occurring    evolve    roles    insults    blood    devastating    understand    mechanisms    endothelial    platelets    70    clots    independently    barrier    protective    rupture    plug    haemorrhage    pathogenesis    intervention    ia    activated    morbidity    interactions    altered    situations    deleterious    ruptured    therapeutic    limited    points    window    leukocyte    clipping    cellular    linger    inflammation    hemorrhage   

Project "PANDORA" data sheet

The following table provides information about the project.


Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2018-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Intracranial aneurysms (IA) with and without subarachnoid haemorrhage (SAH) linger as a potentially devastating clinical problem. Current therapeutic options are limited to invasive therapies, namely microsurgical clipping and endovascular treatment, both of which carry a significant risk of procedural morbidity. Increasing evidence points to inflammation as one of the leading factors in the pathogenesis of IA. Intrasaccular thrombus formation is a common feature of intracranial aneurysm occurring in 25% of unruptured and 70% of ruptured IA. In addition to forming clots, activated platelets support leukocyte recruitment. This cross-talk is a common feature in thrombo-inflammatory vascular disease. Despite these deleterious aspects of platelets, they also prevent local hemorrhage in inflammatory situations independently of their ability to form a platelet plug. The pathophysiological evolution of IA events seems driven by complex cellular interactions between different cell types including platelets, leukocytes and vascular cells (endothelial cells, smooth muscle cells). We hypothesize that the role of platelet roles may evolve throughout the development of IA: initially playing a protective role of in the maintenance of the blood brain barrier in response to inflammation and contributing later to intrasaccular thrombus formation. Therefore, altered platelet function may result in a loss of protection against vascular inflammatory insults. The main objective of this proposal is to better understand and decipher platelet mechanisms during IA formation and rupture. In this current application, we will (i) define platelet activation mechanisms in the development of IA and the impact on the blood-brain barrier integrity, (ii) test efficient anti-platelet therapies in the development and rupture of IA, (iii) define an efficient therapeutic window to intervene on platelet activation (prevention or intervention).


year authors and title journal last update
List of publications.
2018 Yacine Boulaftali, Marie-Anne Mawhin, Martine Jandrot-Perrus, Benoît Ho-Tin-Noé
Glycoprotein VI in securing vascular integrity in inflamed vessels
published pages: 228-239, ISSN: 2475-0379, DOI: 10.1002/rth2.12092
Research and Practice in Thrombosis and Haemostasis 2/2 2019-10-07
2017 Benoit Ho-Tin-Noé, Yacine Boulaftali, Eric Camerer
Platelets and vascular integrity: how platelets prevent bleeding in inflammation
published pages: blood-2017-06-74, ISSN: 0006-4971, DOI: 10.1182/blood-2017-06-742676
Blood 2019-10-07

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The information about "PANDORA" are provided by the European Opendata Portal: CORDIS opendata.

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