Explore the words cloud of the MERC project. It provides you a very rough idea of what is the project "MERC" about.
The following table provides information about the project.
CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.)
|Coordinator Country||Spain [ES]|
|Total cost||170˙121 €|
|EC max contribution||170˙121 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-06-01 to 2019-11-15|
Take a look of project's partnership.
|1||CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.)||ES (MADRID)||coordinator||170˙121.00|
Professor Redondo’s group has recently identified Adamts1 as one of the major mediators in vascular wall remodeling. They showed that Adamts1/-, Adamts1-/- and KD-Adamts1 mice present aortic dilation, aneurysms, medial degeneration and hypotension, leading to the hypothesis that Adamts1 deficiency results in a new familial form of thoracic aortic aneurysm (FTAAD) potentially relevant in human aortic disease. They have also found that nitric oxide synthase (NOS) inhibitors reverse aortic dilation and medial degeneration in Marfan mice and Adamts1-deficient mice. The objective of my project is to study the molecular mechanisms mediating these aortic diseases in mice, and to specifically assess the role of nitric oxide (NO) and related signaling pathways, including those of Adamts1 and its substrates, in the medial degeneration and aortic dilation in both mouse models. I plan to identify potential targets common to both aortopathies and analyze them in patients with syndromic and non-syndromic aortic diseases. I think this project has a strong potential to identify therapeutic targets and prognostic or diagnostic markers for human cardiovascular diseases that constitute one of the major causes of mortality worldwide.
|year||authors and title||journal||last update|
Jorge Oller, Nerea MÃ©ndez-Barbero, E Josue Ruiz, Silvia Villahoz, Marjolijn Renard, Lizet I Canelas, Ana M Briones, Rut Alberca, Noelia Lozano-Vidal, MarÃa A HurlÃ©, Dianna Milewicz, Arturo Evangelista, Mercedes Salaices, J Francisco Nistal, Luis JesÃºs JimÃ©nez-Borreguero, Julie De Backer, Miguel R Campanero, Juan Miguel Redondo
Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome
published pages: 200-212, ISSN: 1078-8956, DOI: 10.1038/nm.4266
|Nature Medicine 23/2||2019-05-27|
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The information about "MERC" are provided by the European Opendata Portal: CORDIS opendata.
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