Explore the words cloud of the FIBROCAN project. It provides you a very rough idea of what is the project "FIBROCAN" about.
The following table provides information about the project.
THE UNIVERSITY OF BIRMINGHAM
|Coordinator Country||United Kingdom [UK]|
|Total cost||195˙454 €|
|EC max contribution||195˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-07-01 to 2018-06-30|
Take a look of project's partnership.
|1||THE UNIVERSITY OF BIRMINGHAM||UK (BIRMINGHAM)||coordinator||195˙454.00|
Lymph nodes are sites where immune responses are robustly initiated. Paradoxically, they are also very common metastatic sites, where tumour progression is well-tolerated. Robust evidence defines a role for fibroblastic reticular cells (FRCs) in preventing T cells from acquiring effector functions within lymph nodes, and deleting T cells that show self-reactivity. FIBROCAN will test the hypothesis that FRCs systematically shut down anti-tumour T cell responses, testing mechanisms of suppression in vitro and in vivo, and charting tumour antigen presentation by FRCs to T cells for the first time.
At the frontier of stromal immunology and cancer biology, FIBROCAN was been designed to inform our fundamental understanding of metastatic cancer progression, particularly relevant to the implementation and design of T cell immunotherapies. This project provides the opportunity for a lasting and multi-disciplinary contribution in the high impact fields of stromal and cancer immunology.
|year||authors and title||journal||last update|
K Knoblich, SM-L Siew, B Parekkadan, S Turley, A Fletcher
Abstracts of ICI 2016 International Congress of Immunology, 21-26 August 2016, Melbourne, Australia
published pages: 1-1274, ISSN: 0014-2980, DOI: 10.1002/eji.201670200
|European Journal of Immunology 46||2019-06-13|
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The information about "FIBROCAN" are provided by the European Opendata Portal: CORDIS opendata.