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MicroNICHE SIGNED

Microfluidic-assisted fabrication of artifical microniches for bone marrow stem cells

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MicroNICHE" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website https://www.researchgate.net/project/MICRONICHE
 Total cost 239˙191 €
 EC max contribution 239˙191 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2020-02-26

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 199˙235.00
2    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) participant 39˙955.00
3    TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK US (NEW YORK) partner 0.00

Map

 Project objective

There is a growing interest in adult stem cells, especially from bone marrow, for regenerative medicine. Hematopoietic stem cells, a type of bone marrow stem cells, alone cannot be expanded in vitro; in vivo, they reside in a microenvironment known as a niche that maintains them in a quiescent state until prompted to differentiate. The stem cell niche provides structural and trophic support and the appropriate homeostasis to regulate stem cell function. Additionally to regulatory factors in these stem cell niches, a number of environmental and mechanical signals arising from the extracellular matrix are crucial regulators of stem cell fate. In order to expedite for basic studies of bone marrow stem cells, and further translational implementation, any realistic approach to the native stem cell niche requires: to engineer a biomimetic 3D-microenvironment, and then to develop artificial microniches with the key functional features reconstructed. High-throughput microfluidic technology offers high promise, however, adaptation to accommodate adult stem cells in artificially fabricated niches remains still a challenge. Microfluidic-assisted culture systems should not only allow maintaining cell homeostasis through biochemical and mechanical stimulation, but also modulating adult stem cell renewal and differentiation through microscale patterning of cells and extracellular materials in biomimetic microniches. This project aims at the microfluidic reconstruction of an artificial stem cell niches. In this proof-of-concept, a bone marrow stem cell microniche with tunable size, material and topography will be developed by integrating novel fabrication microfluidics with material engineering.

 Publications

year authors and title journal last update
List of publications.
2020 P. Carreras, M. Gallardo, A.ortiz, M.L.Morales, T. Cedena, I. Gonzalez and J. Martienz lopez
Hematopoietic stem cell niche generation through droplet microfluidics
published pages: , ISSN: , DOI:
SLAS 2020-04-01
2020 Pilar Carreras, Iciar Gonzalez, Miguel Gallardo, Alejandra Ortiz-Ruiz, Joaquin Martinez-Lopez
Droplet Microfluidics for the ex Vivo Expansion of Human Primary Multiple Myeloma Cells
published pages: 261, ISSN: 2072-666X, DOI: 10.3390/mi11030261
Micromachines 11/3 2020-04-01
2017 P.Carreras, R. Cotrim, F. Monroy, S.K. Sia
Micro-engineering the hematopoietic stem cell niche for regenerative medicine
published pages: , ISSN: , DOI:
2019-09-09
2018 P. Carreras, R. Cotrim, M. Gallardo, A. Ortiz, J. Martinez, S.K. Sia
Microfluidic generation of double layer hydrogel structures for the recapitulation of the hematopoietic stem cell niche
published pages: , ISSN: , DOI:
2019-09-09
2018 Pilar Carreras, Rodrigo Cortrim Chaves, Miguel Gallardo, Alejandra Ortiz, Joaquin Martinez Lopez, Samuel K. Sia
Microengineering double layer hydrogel structures towards the recapitulation of the hematopoietic stem cell niche
published pages: , ISSN: 2095-9273, DOI: 10.1016/j.scib.2018.09.003
Science Bulletin 2019-09-09

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The information about "MICRONICHE" are provided by the European Opendata Portal: CORDIS opendata.

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