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PrenatStressAging SIGNED

Prenatal Stress and Programming of Newborn and Infant Telomere Biology and Cellular Aging

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 PrenatStressAging project word cloud

Explore the words cloud of the PrenatStressAging project. It provides you a very rough idea of what is the project "PrenatStressAging" about.

telomere    area    disorders    telomerase    birth    collected    integrity    occurs    variation    transmitted    utero    definition    prevent    dnamage    exposures    behavioral    hypotheses    methylation    identification    span    plastic    biology    placental    accumulate    advancing    sensitive    initiation    protocol    generationally    elucidation    period    dna    fetal    ecological    developmental    prospective    cellular    primary    psychological    candidate    outcomes    underlying    longitudinal    individuals    pregnancy    age    augment    mechanisms    physiological    intense    till    originate    profile    time    newborn    maternal    child    investigation    diseases    context    dyads    windows    life    influenced    sampling    unborn    delay    gestation    intrauterine    inter    momentary    onset    efforts    ambulatory    cohort    interventions    length    strategies    exposure    350    ema    secondary    capacity    risk    innovative    epigenetic    progression    mother    serial    expression    excess    establishment    aging    stress    ameliorate    damage    infant   

Project "PrenatStressAging" data sheet

The following table provides information about the project.

Coordinator
CHARITE - UNIVERSITAETSMEDIZIN BERLIN 

Organization address
address: Chariteplatz 1
city: BERLIN
postcode: 10117
website: www.charite.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙483˙720 €
 EC max contribution 1˙483˙720 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) coordinator 1˙483˙720.00

Map

 Project objective

The long-term consequences of exposure to excess stress on the initiation and progression of many age-related diseases are well established. The period of intrauterine life represents among the most sensitive developmental windows, at which time the effects of stress may be transmitted inter-generationally from a mother to her as-yet-unborn child. The elucidation of mechanisms underlying such effects is an area of intense interest and investigation. Aging, by definition, occurs with advancing age, and age-related disorders result from exposures over the life span of factors that produce and accumulate damage. The novel concept advanced in this proposal is that the establishment of the integrity of key cellular aging-related processes that determine variation across individuals in the onset and progression of age-related disorders may originate very early in life (in utero) and may be plastic and influenced by developmental conditions. We propose that telomere biology and the epigenetic DNA methylation-based aging profile (DNAmAGE) represent candidate outcomes of particular interest in this context. A prospective, longitudinal cohort study of 350 mother-child dyads will be conducted from early pregnancy through birth till one year of age. Specific hypotheses about the effects of maternal stress and maternal-placental-fetal stress biology on newborn and infant telomere length, telomerase expression capacity, and DNAmAGE will be addressed. Serial measures of maternal psychological, behavioral and physiological characteristics will be collected across gestation using an innovative ecological momentary assessment (EMA) based real-time, ambulatory sampling protocol. The proposed study will help identify new strategies for risk identification and primary and secondary interventions to augment current efforts to prevent, delay and ameliorate age-related disorders.

 Publications

year authors and title journal last update
List of publications.
2018 Sonja Entringer, Karin de Punder, Claudia Buss, Pathik D. Wadhwa
The fetal programming of telomere biology hypothesis: an update
published pages: 20170151, ISSN: 0962-8436, DOI: 10.1098/rstb.2017.0151
Philosophical Transactions of the Royal Society B: Biological Sciences 373/1741 2020-04-08
2019 Karin de Punder, Christine Heim, Pathik D. Wadhwa, Sonja Entringer
Stress and immunosenescence: The role of telomerase
published pages: 87-100, ISSN: 0306-4530, DOI: 10.1016/j.psyneuen.2018.10.019
Psychoneuroendocrinology 101 2020-04-08
2019 Karen L. Lindsay, Claudia Buss, Pathik D. Wadhwa, Sonja Entringer
The Interplay Between Nutrition and Stress in Pregnancy: Implications for Fetal Programming of Brain Development
published pages: 135-149, ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2018.06.021
Biological Psychiatry 85/2 2020-04-08
2018 Christine M. Heim, Sonja Entringer, Claudia Buss
Translating basic research knowledge on the biological embedding of early-life stress into novel approaches for the developmental programming of lifelong health
published pages: , ISSN: 0306-4530, DOI: 10.1016/j.psyneuen.2018.12.011
Psychoneuroendocrinology 2020-04-08
2019 Claudia Lazarides, Elissa S. Epel, Jue Lin, Elizabeth H. Blackburn, Manuel C. Voelkle, Claudia Buss, Hyagriv N. Simhan, Pathik D. Wadhwa, Sonja Entringer
Maternal pro-inflammatory state during pregnancy and newborn leukocyte telomere length: A prospective investigation
published pages: , ISSN: 0889-1591, DOI: 10.1016/j.bbi.2019.04.021
Brain, Behavior, and Immunity 2020-04-08
2018 Karin de Punder, Sonja Entringer, Christine Heim, Christian E. Deuter, Christian Otte, Katja Wingenfeld, Linn K. Kuehl
Inflammatory Measures in Depressed Patients With and Without a History of Adverse Childhood Experiences
published pages: , ISSN: 1664-0640, DOI: 10.3389/fpsyt.2018.00610
Frontiers in Psychiatry 9 2020-04-08

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