Opendata, web and dolomites

PrenatStressAging SIGNED

Prenatal Stress and Programming of Newborn and Infant Telomere Biology and Cellular Aging

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PrenatStressAging project word cloud

Explore the words cloud of the PrenatStressAging project. It provides you a very rough idea of what is the project "PrenatStressAging" about.

sampling    telomere    telomerase    augment    length    innovative    till    fetal    dnamage    identification    stress    transmitted    efforts    profile    exposure    infant    ema    cohort    psychological    underlying    prospective    capacity    physiological    350    collected    child    cellular    disorders    age    behavioral    variation    elucidation    candidate    placental    pregnancy    hypotheses    damage    dyads    longitudinal    definition    intense    individuals    prevent    excess    primary    interventions    time    mechanisms    area    intrauterine    exposures    advancing    unborn    mother    protocol    windows    risk    epigenetic    momentary    diseases    maternal    life    dna    originate    generationally    gestation    developmental    serial    integrity    establishment    outcomes    influenced    newborn    ecological    span    expression    utero    ambulatory    methylation    secondary    accumulate    progression    biology    sensitive    aging    delay    occurs    period    birth    inter    strategies    ameliorate    investigation    context    plastic    onset    initiation   

Project "PrenatStressAging" data sheet

The following table provides information about the project.

Coordinator
CHARITE - UNIVERSITAETSMEDIZIN BERLIN 

Organization address
address: Chariteplatz 1
city: BERLIN
postcode: 10117
website: www.charite.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙483˙720 €
 EC max contribution 1˙483˙720 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) coordinator 1˙483˙720.00

Map

 Project objective

The long-term consequences of exposure to excess stress on the initiation and progression of many age-related diseases are well established. The period of intrauterine life represents among the most sensitive developmental windows, at which time the effects of stress may be transmitted inter-generationally from a mother to her as-yet-unborn child. The elucidation of mechanisms underlying such effects is an area of intense interest and investigation. Aging, by definition, occurs with advancing age, and age-related disorders result from exposures over the life span of factors that produce and accumulate damage. The novel concept advanced in this proposal is that the establishment of the integrity of key cellular aging-related processes that determine variation across individuals in the onset and progression of age-related disorders may originate very early in life (in utero) and may be plastic and influenced by developmental conditions. We propose that telomere biology and the epigenetic DNA methylation-based aging profile (DNAmAGE) represent candidate outcomes of particular interest in this context. A prospective, longitudinal cohort study of 350 mother-child dyads will be conducted from early pregnancy through birth till one year of age. Specific hypotheses about the effects of maternal stress and maternal-placental-fetal stress biology on newborn and infant telomere length, telomerase expression capacity, and DNAmAGE will be addressed. Serial measures of maternal psychological, behavioral and physiological characteristics will be collected across gestation using an innovative ecological momentary assessment (EMA) based real-time, ambulatory sampling protocol. The proposed study will help identify new strategies for risk identification and primary and secondary interventions to augment current efforts to prevent, delay and ameliorate age-related disorders.

 Publications

year authors and title journal last update
List of publications.
2018 Sonja Entringer, Karin de Punder, Claudia Buss, Pathik D. Wadhwa
The fetal programming of telomere biology hypothesis: an update
published pages: 20170151, ISSN: 0962-8436, DOI: 10.1098/rstb.2017.0151
Philosophical Transactions of the Royal Society B: Biological Sciences 373/1741 2020-04-08
2019 Karin de Punder, Christine Heim, Pathik D. Wadhwa, Sonja Entringer
Stress and immunosenescence: The role of telomerase
published pages: 87-100, ISSN: 0306-4530, DOI: 10.1016/j.psyneuen.2018.10.019
Psychoneuroendocrinology 101 2020-04-08
2019 Karen L. Lindsay, Claudia Buss, Pathik D. Wadhwa, Sonja Entringer
The Interplay Between Nutrition and Stress in Pregnancy: Implications for Fetal Programming of Brain Development
published pages: 135-149, ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2018.06.021
Biological Psychiatry 85/2 2020-04-08
2018 Christine M. Heim, Sonja Entringer, Claudia Buss
Translating basic research knowledge on the biological embedding of early-life stress into novel approaches for the developmental programming of lifelong health
published pages: , ISSN: 0306-4530, DOI: 10.1016/j.psyneuen.2018.12.011
Psychoneuroendocrinology 2020-04-08
2019 Claudia Lazarides, Elissa S. Epel, Jue Lin, Elizabeth H. Blackburn, Manuel C. Voelkle, Claudia Buss, Hyagriv N. Simhan, Pathik D. Wadhwa, Sonja Entringer
Maternal pro-inflammatory state during pregnancy and newborn leukocyte telomere length: A prospective investigation
published pages: , ISSN: 0889-1591, DOI: 10.1016/j.bbi.2019.04.021
Brain, Behavior, and Immunity 2020-04-08
2018 Karin de Punder, Sonja Entringer, Christine Heim, Christian E. Deuter, Christian Otte, Katja Wingenfeld, Linn K. Kuehl
Inflammatory Measures in Depressed Patients With and Without a History of Adverse Childhood Experiences
published pages: , ISSN: 1664-0640, DOI: 10.3389/fpsyt.2018.00610
Frontiers in Psychiatry 9 2020-04-08

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PRENATSTRESSAGING" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PRENATSTRESSAGING" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

KineTic (2020)

New Reagents for Quantifying the Routing and Kinetics of T-cell Activation

Read More  

INSPIRE (2019)

System-wide discovery and analysis of inositol pyrophosphate signaling networks in plants

Read More  

CARBYNE (2020)

New carbon reactivity rules for molecular editing

Read More