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Opto-Sleep SIGNED

All-optical deconstruction of thalamic control of sleep-wake states.

Total Cost €


EC-Contrib. €






 Opto-Sleep project word cloud

Explore the words cloud of the Opto-Sleep project. It provides you a very rough idea of what is the project "Opto-Sleep" about.

stable    movement    thalamo    paradoxical    hypothesizes    subcortical    sleep    behaving    anterior    substrates    bridging    divided    origin    perspective    cmt    posterior    combination    topographically    cycles    while    subject    electrophysiology    sub    functional    precise    balance    nuclei    clearance    appropriate    hub    temporally    experimental    inputs    cellular    mammalian    cells    mechanism    pattern    mice    spiking    functions    perturbational    successive    brain    mechanistic    hypothalamic    completion    laboratory    dissected    eye    intense    thalamus    integrates    optogenetics    brainstem    observational    unclear    hypothalamus    homeostasis    density    simultaneous    networks    network    circuits    dynamics    arousal    consciousness    rapid    rely    thalamic    wakefulness    controls    located    modulation    cortical    connections    coherence    memory    circuit    anabolism    trn    neural    structures    hypothesis    plasticity    consolidation    wake   

Project "Opto-Sleep" data sheet

The following table provides information about the project.


Organization address
city: BERN
postcode: 3012

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙915˙000 €
 EC max contribution 1˙915˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 1˙915˙000.00


 Project objective

While the functions of sleep are still a matter of debate and may include memory consolidation, brain clearance, anabolism and plasticity, the neural substrates of sleep and wake states are the subject of intense study. Successive sleep-wake cycles rely on an appropriate balance between sleep-promoting nuclei of the brain located in the anterior hypothalamus and, arousal-promoting nuclei from the posterior hypothalamus and the brainstem. My laboratory identified different subsets of hypothalamic cells that controls wakefulness and rapid-eye movement (also called paradoxical) sleep using optogenetics in combination with high-density electrophysiology in freely-behaving mice. We further identified their connections with (and functional modulation of) other sleep-wake circuits throughout the brain. Although we and others have dissected important subcortical and cortical sleep-wake circuits in the brain, the precise mechanism bridging sub-cortical circuits to thalamic and cortical networks remains unclear.

I hypothesizes that the thalamus represents a hub that integrates sleep-wake inputs of both subcortical and cortical origin into stable sleep-wake states, through topographically distinct sub-cortical inputs and temporally precise circuit dynamics (spiking pattern, coherence).

To test this hypothesis, my experimental objectives are divided into three specific aims: 1) Identify the simultaneous cellular dynamics of thalamo-cortical network activity across sleep-wake states (Observational approach; Year 1-3) 2) Characterize the subcortical modulation of thalamic structures across sleep-wake states (Perturbational approach; Year 2-4) 3) Study the role of TRN/CMT circuits in sleep homeostasis and consciousness (Functional approach; Year 4-5)

Completion of this project will provide a mechanistic perspective on sub-cortical, thalamo-cortical and cortical control of sleep-wake states, sleep homeostasis and consciousness in the mammalian brain.


year authors and title journal last update
List of publications.
2019 Mojtaba Bandarabadi, Heidemarie Gast, Christian Rummel, Claudio Bassetti, Antoine Adamantidis, Kaspar Schindler, Frederic Zubler
Assessing Epileptogenicity Using Phase-Locked High Frequency Oscillations: A Systematic Comparison of Methods
published pages: , ISSN: 1664-2295, DOI: 10.3389/fneur.2019.01132
Frontiers in Neurology 10 2020-02-06
2017 Richard Boyce, Sylvain Williams, Antoine Adamantidis
REM sleep and memory
published pages: 167-177, ISSN: 0959-4388, DOI: 10.1016/j.conb.2017.05.001
Current Opinion in Neurobiology 44 2020-02-06
2019 Claudio L. A. Bassetti, Antoine Adamantidis, Denis Burdakov, Fang Han, Steffen Gay, Ulf Kallweit, Ramin Khatami, Frits Koning, Brigitte R. Kornum, Gert Jan Lammers, Roland S. Liblau, Pierre H. Luppi, Geert Mayer, Thomas Pollmächer, Takeshi Sakurai, Federica Sallusto, Thomas E. Scammell, Mehdi Tafti, Yves Dauvilliers
Narcolepsy — clinical spectrum, aetiopathophysiology, diagnosis and treatment
published pages: 519-539, ISSN: 1759-4758, DOI: 10.1038/s41582-019-0226-9
Nature Reviews Neurology 15/9 2020-02-06
2019 Antoine R. Adamantidis, Carolina Gutierrez Herrera, Thomas C. Gent
Oscillating circuitries in the sleeping brain
published pages: 746-762, ISSN: 1471-003X, DOI: 10.1038/s41583-019-0223-4
Nature Reviews Neuroscience 20/12 2020-02-06
2020 A R Adamantidis, M H Schmidt, M E Carter, D Burdakov, C Peyron, Thomas E Scammell
A circuit perspective on narcolepsy
published pages: , ISSN: 0161-8105, DOI: 10.1093/sleep/zsz296
Sleep 2020-02-06
2018 Blerina Latifi, Antoine Adamantidis, Claudio Bassetti, Markus H. Schmidt
Sleep-Wake Cycling and Energy Conservation: Role of Hypocretin and the Lateral Hypothalamus in Dynamic State-Dependent Resource Optimization
published pages: , ISSN: 1664-2295, DOI: 10.3389/fneur.2018.00790
Frontiers in Neurology 9 2020-02-06
2019 Đorđe Miladinović, Christine Muheim, Stefan Bauer, Andrea Spinnler, Daniela Noain, Mojtaba Bandarabadi, Benjamin Gallusser, Gabriel Krummenacher, Christian Baumann, Antoine Adamantidis, Steven A. Brown, Joachim M. Buhmann
SPINDLE: End-to-end learning from EEG/EMG to extrapolate animal sleep scoring across experimental settings, labs and species
published pages: e1006968, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1006968
PLOS Computational Biology 15/4 2020-02-06
2017 Richard Boyce, Antoine Adamantidis
REM Sleep on It!
published pages: 375-375, ISSN: 0893-133X, DOI: 10.1038/npp.2016.227
Neuropsychopharmacology 42/1 2020-02-06
2019 Armand Mensen, Andrea Pigorini, Laura Facchin, Cornelia Schöne, Sasha D\'Ambrosio, Jasmine Jendoubi, Valeria Jaramillo, Kathrin Chiffi, Aleksandra K. Eberhard-Moscicka, Simone Sarasso, Antoine Adamantidis, René M. Müri, Reto Huber, Marcello Massimini, Claudio Bassetti
Sleep as a model to understand neuroplasticity and recovery after stroke: Observational, perturbational and interventional approaches
published pages: 37-43, ISSN: 0165-0270, DOI: 10.1016/j.jneumeth.2018.12.011
Journal of Neuroscience Methods 313 2020-02-06
2018 Thomas C. Gent, Mojtaba Bandarabadi, Carolina Gutierrez Herrera, Antoine R. Adamantidis
Thalamic dual control of sleep and wakefulness
published pages: 974-984, ISSN: 1097-6256, DOI: 10.1038/s41593-018-0164-7
Nature Neuroscience 21/7 2019-04-26

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