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Antibodyomics SIGNED

Vaccine profiling and immunodiagnostic discovery by high-throughput antibody repertoire analysis

Total Cost €

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EC-Contrib. €

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Partnership

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Project "Antibodyomics" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙492˙586 €
 EC max contribution 1˙492˙586 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 1˙492˙586.00

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 Project objective

Vaccines and immunodiagnostics have been vital for public health and medicine, however a quantitative molecular understanding of vaccine-induced antibody responses is lacking. Antibody research is currently going through a big-data driven revolution, largely due to progress in next-generation sequencing (NGS) and bioinformatic analysis of antibody repertoires. A main advantage of high-throughput antibody repertoire analysis is that it provides a wealth of quantitative information not possible with other classical methods of antibody analysis (i.e., serum titers); this information includes: clonal distribution and diversity, somatic hypermutation patterns, and lineage tracing. In preliminary work my group has established standardized methods for antibody repertoire NGS, including an experimental-bioinformatic pipeline for error and bias correction that enables highly accurate repertoire sequencing and analysis. The overall goal of this proposal will be to apply high-throughput antibody repertoire analysis for quantitative vaccine profiling and discovery of next-generation immunodiagnostics. Using mouse subunit vaccination as our model system, we will answer for the first time, a fundamental biological question within the context of antibody responses - what is the link between genotype (antibody repertoire) and phenotype (serum antibodies)? We will expand upon this approach for improved rational vaccine design by quantitatively determining the impact of a comprehensive set of subunit vaccination parameters on complete antibody landscapes. Finally, we will develop advanced bioinformatic methods to discover immunodiagnostics based on antibody repertoire sequences. In summary, this proposal lays the foundation for fundamentally new approaches in the quantitative analysis of antibody responses, which long-term will promote the development of next-generation vaccines and immunodiagnostics.

 Publications

year authors and title journal last update
List of publications.
2018 Enkelejda Miho, Alexander Yermanos, Cédric R. Weber, Christoph T. Berger, Sai T. Reddy, Victor Greiff
Computational Strategies for Dissecting the High-Dimensional Complexity of Adaptive Immune Repertoires
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00224
Frontiers in Immunology 9 2019-04-20
2017 Victor Greiff, Cédric R. Weber, Johannes Palme, Ulrich Bodenhofer, Enkelejda Miho, Ulrike Menzel, Sai T. Reddy
Learning the High-Dimensional Immunogenomic Features That Predict Public and Private Antibody Repertoires
published pages: 2985-2997, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1700594
The Journal of Immunology 199/8 2019-04-20
2018 Alexander Dimitri Yermanos, Andreas Kevin Dounas, Tanja Stadler, Annette Oxenius, Sai T. Reddy
Tracing Antibody Repertoire Evolution by Systems Phylogeny
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02149
Frontiers in Immunology 9 2019-04-20
2018 Derek M Mason, Cédric R Weber, Cristina Parola, Simon M Meng, Victor Greiff, William J Kelton, Sai T Reddy
High-throughput antibody engineering in mammalian cells by CRISPR/Cas9-mediated homology-directed mutagenesis
published pages: 7436-7449, ISSN: 0305-1048, DOI: 10.1093/nar/gky550
Nucleic Acids Research 46/14 2019-04-20
2018 Cristina Parola, Daniel Neumeier, Sai T. Reddy
Integrating high-throughput screening and sequencing for monoclonal antibody discovery and engineering
published pages: 31-41, ISSN: 0019-2805, DOI: 10.1111/imm.12838
Immunology 153/1 2019-04-20

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