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TransPhorm SIGNED

Single molecule imaging of transmembrane protein structure and function in their native state

Total Cost €


EC-Contrib. €






 TransPhorm project word cloud

Explore the words cloud of the TransPhorm project. It provides you a very rough idea of what is the project "TransPhorm" about.

spatial    selectivity    ion    sensitivity    critical    communication    understand    magnetometry    spins    native    39    technologies    outstanding    techniques    weak    transmembrane    suitable    realisation    cells    resolution    illumination    reside    19    biological    dynamic    nmr    complementary    external    nuclear    characterised    single    resonance    implementations    nanoscale    vacancy    situ    pave    structure    environment    widefield    scientific    nitrogen    23    potassium    molecular    transphorm    extreme    fluorine    internal    functional    unprecedented    reporters    platform    characterisation    attempts    tmp    tremendous    ground    speed    nv    totally    dependent    proteins    membrane    interaction    function    molecule    total    spectroscopy    reflection    imaging    multitude    transformative    breaking    pioneer    magnetic    surpass    despite    mapping    microscopy    cellular    tmps    underpin    demanding    strategy    millisecond    technically    specificity    detection    solution    local    gains    structural    originating    sodium    breakthrough    structured    untravelled   

Project "TransPhorm" data sheet

The following table provides information about the project.


Organization address
city: KEELE
postcode: ST5 5BG

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙434˙650 €
 EC max contribution 2˙434˙650 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF KEELE UK (KEELE) coordinator 2˙434˙650.00


 Project objective

TransPhorm will pioneer a transformative technology platform based on Nitrogen Vacancy (NV) magnetometry to enable the structure and function of transmembrane proteins (TMPs) to be studied in their native state with unprecedented sensitivity and resolution. TMPs reside in the membrane of biological cells and are critical to cellular function and communication. It is essential that TMPs are characterised in their native state as their structure and function is dependent on their interaction with the local environment. This is technically demanding and despite previous attempts using a multitude of complementary techniques no single method has provided a suitable solution. Here a breakthrough approach will be taken to demonstrate in situ TMP characterisation with single molecule sensitivity, nanoscale spatial resolution and millisecond measurement speed.

The concepts proposed in TransPhorm are distinct from current implementations of NV magnetometry for detection and mapping of weak magnetic fields originating from external nuclear spins. Here magnetic field mapping will be achieved using a totally new approach based on widefield, high speed structured illumination total internal reflection microscopy. The concepts TransPhorm are built on will also enable structural and functional single molecular characterisation with high specificity by exploiting the outstanding sensitivity to the local environment of fluorine-19 Nuclear Magnetic Resonance (NMR) reporters and the ion selectivity of sodium-23 and potassium-39 NMR spectroscopy.

In short, TransPhorm will deliver a ground-breaking technology to far surpass current state-of-the-art techniques and provide the extreme sensitivity needed to understand the molecular scale dynamic changes that underpin TMP function. Overall the strategy and technologies proposed here will pave an untravelled path to the realisation of nanoscale NMR imaging and deliver tremendous scientific gains.


year authors and title journal last update
List of publications.
2019 Valentin Radu, Joshua Colm Price, Simon James Levett, Kaarjel K. Narayanasamy, Thomas David Bateman-Price, Philippe Barrie Wilson, Melissa Louise Mather
Dynamic quantum sensing of paramagnetic species using nitrogen-vacancy centers in diamond
published pages: , ISSN: , DOI:
2019 Benita C. Percival, Martin Grootveld, Miles Gibson, Yasan Osman, Marco Molinari, Fereshteh Jafari, Tarsem Sahota, Mark Martin, Federico Casanova, Melissa L. Mather, Mark Edgar, Jinit Masania, Philippe B. Wilson
Low-Field, Benchtop NMR Spectroscopy as a Potential Tool for Point-of-Care Diagnostics of Metabolic Conditions: Validation, Protocols and Computational Models
published pages: 2, ISSN: 2571-5135, DOI: 10.3390/ht8010002
High-Throughput 8/1 2019-07-09
2019 Joshua C. Price, Simon J. Levett, Valentin Radu, David A. Simpson, Aina Mogas Barcons, Christopher F. Adams, Melissa L. Mather
Quantum Sensing in a Physiological‐Like Cell Niche Using Fluorescent Nanodiamonds Embedded in Electrospun Polymer Nanofibers
published pages: 1900455, ISSN: 1613-6810, DOI: 10.1002/smll.201900455
Small 15/22 2019-09-04
2019 Grootveld, Martin; Percival, Benita; Gibson, Miles; Osman, Yasan; Edgar, Mark; Molinari, Marco; Mather, Melissa L.; Casanova, Federico; Wilson, Philippe B.
Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis
published pages: , ISSN: 0003-2670, DOI: 10.1016/j.aca.2019.02.026
Analytica Chimica Acta 2019-07-09

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The information about "TRANSPHORM" are provided by the European Opendata Portal: CORDIS opendata.

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