Opendata, web and dolomites

TransPhorm SIGNED

Single molecule imaging of transmembrane protein structure and function in their native state

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TransPhorm project word cloud

Explore the words cloud of the TransPhorm project. It provides you a very rough idea of what is the project "TransPhorm" about.

molecule    transformative    total    native    nuclear    reside    interaction    situ    ion    function    sensitivity    breaking    techniques    tremendous    reflection    characterised    outstanding    magnetic    nv    demanding    mapping    gains    sodium    tmps    resonance    implementations    membrane    fluorine    widefield    multitude    despite    underpin    cells    pioneer    critical    technologies    surpass    specificity    scientific    vacancy    imaging    39    single    strategy    reporters    transphorm    platform    pave    weak    microscopy    environment    19    untravelled    dependent    suitable    originating    illumination    ground    speed    biological    structured    communication    extreme    tmp    understand    potassium    spatial    functional    spins    dynamic    nmr    spectroscopy    selectivity    millisecond    nitrogen    internal    local    nanoscale    magnetometry    breakthrough    structural    23    realisation    resolution    solution    transmembrane    unprecedented    molecular    characterisation    cellular    attempts    structure    technically    totally    detection    complementary    proteins    external   

Project "TransPhorm" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF KEELE 

Organization address
address: KEELE UNIVERSITY FINANCE DPT
city: KEELE
postcode: ST5 5BG
website: www.keele.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙434˙650 €
 EC max contribution 2˙434˙650 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF KEELE UK (KEELE) coordinator 2˙434˙650.00

Map

 Project objective

TransPhorm will pioneer a transformative technology platform based on Nitrogen Vacancy (NV) magnetometry to enable the structure and function of transmembrane proteins (TMPs) to be studied in their native state with unprecedented sensitivity and resolution. TMPs reside in the membrane of biological cells and are critical to cellular function and communication. It is essential that TMPs are characterised in their native state as their structure and function is dependent on their interaction with the local environment. This is technically demanding and despite previous attempts using a multitude of complementary techniques no single method has provided a suitable solution. Here a breakthrough approach will be taken to demonstrate in situ TMP characterisation with single molecule sensitivity, nanoscale spatial resolution and millisecond measurement speed.

The concepts proposed in TransPhorm are distinct from current implementations of NV magnetometry for detection and mapping of weak magnetic fields originating from external nuclear spins. Here magnetic field mapping will be achieved using a totally new approach based on widefield, high speed structured illumination total internal reflection microscopy. The concepts TransPhorm are built on will also enable structural and functional single molecular characterisation with high specificity by exploiting the outstanding sensitivity to the local environment of fluorine-19 Nuclear Magnetic Resonance (NMR) reporters and the ion selectivity of sodium-23 and potassium-39 NMR spectroscopy.

In short, TransPhorm will deliver a ground-breaking technology to far surpass current state-of-the-art techniques and provide the extreme sensitivity needed to understand the molecular scale dynamic changes that underpin TMP function. Overall the strategy and technologies proposed here will pave an untravelled path to the realisation of nanoscale NMR imaging and deliver tremendous scientific gains.

 Publications

year authors and title journal last update
List of publications.
2019 Valentin Radu, Joshua Colm Price, Simon James Levett, Kaarjel K. Narayanasamy, Thomas David Bateman-Price, Philippe Barrie Wilson, Melissa Louise Mather
Dynamic quantum sensing of paramagnetic species using nitrogen-vacancy centers in diamond
published pages: , ISSN: , DOI:
2019-08-29
2019 Benita C. Percival, Martin Grootveld, Miles Gibson, Yasan Osman, Marco Molinari, Fereshteh Jafari, Tarsem Sahota, Mark Martin, Federico Casanova, Melissa L. Mather, Mark Edgar, Jinit Masania, Philippe B. Wilson
Low-Field, Benchtop NMR Spectroscopy as a Potential Tool for Point-of-Care Diagnostics of Metabolic Conditions: Validation, Protocols and Computational Models
published pages: 2, ISSN: 2571-5135, DOI: 10.3390/ht8010002
High-Throughput 8/1 2019-07-09
2019 Joshua C. Price, Simon J. Levett, Valentin Radu, David A. Simpson, Aina Mogas Barcons, Christopher F. Adams, Melissa L. Mather
Quantum Sensing in a Physiological‐Like Cell Niche Using Fluorescent Nanodiamonds Embedded in Electrospun Polymer Nanofibers
published pages: 1900455, ISSN: 1613-6810, DOI: 10.1002/smll.201900455
Small 15/22 2019-09-04
2019 Grootveld, Martin; Percival, Benita; Gibson, Miles; Osman, Yasan; Edgar, Mark; Molinari, Marco; Mather, Melissa L.; Casanova, Federico; Wilson, Philippe B.
Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis
published pages: , ISSN: 0003-2670, DOI: 10.1016/j.aca.2019.02.026
Analytica Chimica Acta 2019-07-09

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TRANSPHORM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TRANSPHORM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ENUF (2019)

Evaluation of Novel Ultra-Fast selective III-V Epitaxy

Read More  

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More  

REAL (2019)

Rights and Egalitarianism

Read More