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TransPhorm SIGNED

Single molecule imaging of transmembrane protein structure and function in their native state

Total Cost €

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EC-Contrib. €

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Partnership

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 TransPhorm project word cloud

Explore the words cloud of the TransPhorm project. It provides you a very rough idea of what is the project "TransPhorm" about.

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Project "TransPhorm" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF KEELE 

Organization address
address: KEELE UNIVERSITY FINANCE DPT
city: KEELE
postcode: ST5 5BG
website: www.keele.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 2˙434˙650 €
 EC max contribution 2˙434˙650 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF KEELE UK (KEELE) coordinator 2˙434˙650.00

Map

 Project objective

TransPhorm will pioneer a transformative technology platform based on Nitrogen Vacancy (NV) magnetometry to enable the structure and function of transmembrane proteins (TMPs) to be studied in their native state with unprecedented sensitivity and resolution. TMPs reside in the membrane of biological cells and are critical to cellular function and communication. It is essential that TMPs are characterised in their native state as their structure and function is dependent on their interaction with the local environment. This is technically demanding and despite previous attempts using a multitude of complementary techniques no single method has provided a suitable solution. Here a breakthrough approach will be taken to demonstrate in situ TMP characterisation with single molecule sensitivity, nanoscale spatial resolution and millisecond measurement speed.

The concepts proposed in TransPhorm are distinct from current implementations of NV magnetometry for detection and mapping of weak magnetic fields originating from external nuclear spins. Here magnetic field mapping will be achieved using a totally new approach based on widefield, high speed structured illumination total internal reflection microscopy. The concepts TransPhorm are built on will also enable structural and functional single molecular characterisation with high specificity by exploiting the outstanding sensitivity to the local environment of fluorine-19 Nuclear Magnetic Resonance (NMR) reporters and the ion selectivity of sodium-23 and potassium-39 NMR spectroscopy.

In short, TransPhorm will deliver a ground-breaking technology to far surpass current state-of-the-art techniques and provide the extreme sensitivity needed to understand the molecular scale dynamic changes that underpin TMP function. Overall the strategy and technologies proposed here will pave an untravelled path to the realisation of nanoscale NMR imaging and deliver tremendous scientific gains.

 Publications

year authors and title journal last update
List of publications.
2019 Valentin Radu, Joshua Colm Price, Simon James Levett, Kaarjel K. Narayanasamy, Thomas David Bateman-Price, Philippe Barrie Wilson, Melissa Louise Mather
Dynamic quantum sensing of paramagnetic species using nitrogen-vacancy centers in diamond
published pages: , ISSN: , DOI:
2019-08-29
2019 Benita C. Percival, Martin Grootveld, Miles Gibson, Yasan Osman, Marco Molinari, Fereshteh Jafari, Tarsem Sahota, Mark Martin, Federico Casanova, Melissa L. Mather, Mark Edgar, Jinit Masania, Philippe B. Wilson
Low-Field, Benchtop NMR Spectroscopy as a Potential Tool for Point-of-Care Diagnostics of Metabolic Conditions: Validation, Protocols and Computational Models
published pages: 2, ISSN: 2571-5135, DOI: 10.3390/ht8010002
High-Throughput 8/1 2019-07-09
2019 Joshua C. Price, Simon J. Levett, Valentin Radu, David A. Simpson, Aina Mogas Barcons, Christopher F. Adams, Melissa L. Mather
Quantum Sensing in a Physiological‐Like Cell Niche Using Fluorescent Nanodiamonds Embedded in Electrospun Polymer Nanofibers
published pages: 1900455, ISSN: 1613-6810, DOI: 10.1002/smll.201900455
Small 15/22 2019-09-04
2019 Grootveld, Martin; Percival, Benita; Gibson, Miles; Osman, Yasan; Edgar, Mark; Molinari, Marco; Mather, Melissa L.; Casanova, Federico; Wilson, Philippe B.
Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis
published pages: , ISSN: 0003-2670, DOI: 10.1016/j.aca.2019.02.026
Analytica Chimica Acta 2019-07-09

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