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TransPhorm SIGNED

Single molecule imaging of transmembrane protein structure and function in their native state

Total Cost €


EC-Contrib. €






 TransPhorm project word cloud

Explore the words cloud of the TransPhorm project. It provides you a very rough idea of what is the project "TransPhorm" about.

implementations    structural    outstanding    breaking    totally    scientific    reside    techniques    nitrogen    biological    selectivity    local    function    mapping    internal    platform    imaging    extreme    19    detection    nuclear    proteins    39    potassium    untravelled    reporters    vacancy    external    total    dynamic    structured    structure    demanding    situ    unprecedented    originating    understand    breakthrough    magnetic    pave    suitable    ground    23    characterised    complementary    functional    resonance    technologies    spins    weak    nv    reflection    ion    membrane    single    specificity    spatial    transphorm    tremendous    resolution    multitude    cells    attempts    microscopy    fluorine    sensitivity    solution    underpin    transformative    molecule    native    magnetometry    sodium    millisecond    interaction    dependent    tmps    communication    transmembrane    illumination    characterisation    gains    molecular    environment    realisation    speed    strategy    critical    pioneer    technically    widefield    surpass    spectroscopy    despite    tmp    nanoscale    nmr    cellular   

Project "TransPhorm" data sheet

The following table provides information about the project.


Organization address
city: KEELE
postcode: ST5 5BG

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙434˙650 €
 EC max contribution 2˙434˙650 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF KEELE UK (KEELE) coordinator 2˙434˙650.00


 Project objective

TransPhorm will pioneer a transformative technology platform based on Nitrogen Vacancy (NV) magnetometry to enable the structure and function of transmembrane proteins (TMPs) to be studied in their native state with unprecedented sensitivity and resolution. TMPs reside in the membrane of biological cells and are critical to cellular function and communication. It is essential that TMPs are characterised in their native state as their structure and function is dependent on their interaction with the local environment. This is technically demanding and despite previous attempts using a multitude of complementary techniques no single method has provided a suitable solution. Here a breakthrough approach will be taken to demonstrate in situ TMP characterisation with single molecule sensitivity, nanoscale spatial resolution and millisecond measurement speed.

The concepts proposed in TransPhorm are distinct from current implementations of NV magnetometry for detection and mapping of weak magnetic fields originating from external nuclear spins. Here magnetic field mapping will be achieved using a totally new approach based on widefield, high speed structured illumination total internal reflection microscopy. The concepts TransPhorm are built on will also enable structural and functional single molecular characterisation with high specificity by exploiting the outstanding sensitivity to the local environment of fluorine-19 Nuclear Magnetic Resonance (NMR) reporters and the ion selectivity of sodium-23 and potassium-39 NMR spectroscopy.

In short, TransPhorm will deliver a ground-breaking technology to far surpass current state-of-the-art techniques and provide the extreme sensitivity needed to understand the molecular scale dynamic changes that underpin TMP function. Overall the strategy and technologies proposed here will pave an untravelled path to the realisation of nanoscale NMR imaging and deliver tremendous scientific gains.


year authors and title journal last update
List of publications.
2019 Valentin Radu, Joshua Colm Price, Simon James Levett, Kaarjel K. Narayanasamy, Thomas David Bateman-Price, Philippe Barrie Wilson, Melissa Louise Mather
Dynamic quantum sensing of paramagnetic species using nitrogen-vacancy centers in diamond
published pages: , ISSN: , DOI:
2019 Benita C. Percival, Martin Grootveld, Miles Gibson, Yasan Osman, Marco Molinari, Fereshteh Jafari, Tarsem Sahota, Mark Martin, Federico Casanova, Melissa L. Mather, Mark Edgar, Jinit Masania, Philippe B. Wilson
Low-Field, Benchtop NMR Spectroscopy as a Potential Tool for Point-of-Care Diagnostics of Metabolic Conditions: Validation, Protocols and Computational Models
published pages: 2, ISSN: 2571-5135, DOI: 10.3390/ht8010002
High-Throughput 8/1 2019-07-09
2019 Joshua C. Price, Simon J. Levett, Valentin Radu, David A. Simpson, Aina Mogas Barcons, Christopher F. Adams, Melissa L. Mather
Quantum Sensing in a Physiological‐Like Cell Niche Using Fluorescent Nanodiamonds Embedded in Electrospun Polymer Nanofibers
published pages: 1900455, ISSN: 1613-6810, DOI: 10.1002/smll.201900455
Small 15/22 2019-09-04
2019 Grootveld, Martin; Percival, Benita; Gibson, Miles; Osman, Yasan; Edgar, Mark; Molinari, Marco; Mather, Melissa L.; Casanova, Federico; Wilson, Philippe B.
Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis
published pages: , ISSN: 0003-2670, DOI: 10.1016/j.aca.2019.02.026
Analytica Chimica Acta 2019-07-09

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