Opendata, web and dolomites


Genetic Determinants of the Epigenome

Total Cost €


EC-Contrib. €






Project "Gen-Epix" data sheet

The following table provides information about the project.


Organization address
postcode: EH8 9YL

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙499˙717 €
 EC max contribution 2˙499˙717 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 2˙499˙717.00


 Project objective

Decoding of the genome during development and differentiation depends on sequence-specific DNA binding proteins that regulate transcription. The activity of transcription factors is constrained, however, by chromatin structure and by modification of histones and DNA, known collectively as the “epigenome”. Diseased states, particularly cancers, are often accompanied by epigenomic disturbances that contribute to aetiology, but despite much research the molecular determinants of chromatin and DNA marking remain poorly understood. A widespread view is that the epigenome responds to developmental decisions or environmental impacts that are memorised by the epigenetic machinery. Complementary to this “memory” hypothesis, there is evidence that the epigenome can directly reflect the underlying DNA sequence. We aim to explore genetic determinants of the epigenome based on our over-arching hypothesis that chromatin structure is influenced by the interaction of DNA binding proteins with short, frequent base sequence motifs. Prototypes for this scenario are proteins that bind to the two base pair sequence CpG. These proteins accumulate at CpG islands (CGIs), which are platforms for gene regulation, where they recruit multi-protein complexes that lay down epigenetic marks. By identifying and characterising novel DNA-binding proteins that sense global properties of the DNA sequence (e.g. base composition), we will address several major unanswered questions about genome regulation, including the origin of global DNA methylation patterns and the causal basis of higher order chromosome structures. Our research programme will advance genome biology and shed light on the role of epigenetic signalling in development. In particular it will explore the extent to which the epigenome is “hard-wired” by genes, with important implications for health.


year authors and title journal last update
List of publications.
2017 Bird, Adrian
Genetic determinants of the epigenome in development and cancer
published pages: 1-6, ISSN: 1424-7860, DOI: 10.4414/smw.2017.14523
Swiss Medical Weekly 147/4142 2020-01-28

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GEN-EPIX" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GEN-EPIX" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

MOCHA (2019)

Understanding and leveraging ‘moments of change’ for pro-environmental behaviour shifts

Read More  

AllergenDetect (2019)

Comprehensive allergen detection using synthetic DNA libraries

Read More  

CerQuS (2019)

Certified Quantum Security

Read More