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TIME FOR A CHANGE: An out-of-the-box approach to unravel transitions in depression

Total Cost €


EC-Contrib. €






Project "TRANS-ID" data sheet

The following table provides information about the project.


Organization address
address: HANZEPLEIN 1
postcode: 9713 GZ

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 1˙994˙076 €
 EC max contribution 1˙994˙076 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-08-01   to  2021-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Major Depression (MD) is often chronic and characterized by frequent recurrences of symptoms and burden. The need to better understand how and when relevant transitions in symptoms occur is urgent. A seemingly unsolvable scientific problem is the enormous etiological complexity of mental disorders such as MD, involving continuously ongoing gene-environment interactions that act in highly person-specific ways. This hampers accurate assessment of personalized risk. I will use an out-of-the-box and interdisciplinary approach to tackle this problem. MD is not the only phenomenon that is influenced by many factors, is unpredictable and makes sudden transitions. This is also the case for other so-called complex dynamical systems such as climate or water quality of lakes. For the latter systems generic early warning signals (EWS) have been found that indicate the approach of a transition. I hypothesize that transitions in mood can be anticipated using the same generic EWS as reported for other complex dynamical systems. Finding direct evidence for this hypothesis requires a completely novel approach in the field of psychiatry, which would involve (i) a design that captures data of the complete dynamic process within a single individual in order to detect the timing of EWS and sudden transitions in symptoms, prospectively and intra-individually, and (ii) frequent replications of these individual experiments. With help of recent technology and my acquired expertise I will use precisely this novel approach to search for personalized EWS that anticipate critical transitions in depression. This is the aim of my project. Evidence that transitions in mood behave according to principles of complex dynamical systems would change the field majorly. First, it would lead to a new understanding of mental disorders and the way we study them. Second, it would yield a sophisticated novel way of obtaining personalized and clinically relevant information on risk for transitions.


year authors and title journal last update
List of publications.
2017 Marieke Wichers, Johanna T. W. Wigman, Laura F. Bringmann, Peter de Jonge
Mental disorders as networks: some cautionary reflections on a promising approach
published pages: 143-145, ISSN: 0933-7954, DOI: 10.1007/s00127-016-1335-z
Social Psychiatry and Psychiatric Epidemiology 52/2 2019-06-18
2018 F.M. Bos, F.J. Blaauw, E. Snippe, L. van der Krieke, P. de Jonge, M. Wichers
Exploring the emotional dynamics of subclinically depressed individuals with and without anhedonia: An experience sampling study
published pages: 186-193, ISSN: 0165-0327, DOI: 10.1016/j.jad.2017.12.017
Journal of Affective Disorders 228 2019-06-18
2017 Evelien Snippe, Wolfgang Viechtbauer, Nicole Geschwind, Annelie Klippel, Peter de Jonge, Marieke Wichers
The Impact of Treatments for Depression on the Dynamic Network Structure of Mental States: Two Randomized Controlled Trials
published pages: 46523, ISSN: 2045-2322, DOI: 10.1038/srep46523
Scientific Reports 7 2019-06-18
2018 Sanne H. Booij, Evelien Snippe, Bertus F. Jeronimus, Marieke Wichers, Johanna T.W. Wigman
Affective reactivity to daily life stress: Relationship to positive psychotic and depressive symptoms in a general population sample
published pages: 474-481, ISSN: 0165-0327, DOI: 10.1016/j.jad.2017.08.051
Journal of Affective Disorders 225 2019-06-18
2017 Barnaby Nelson, Patrick D. McGorry, Marieke Wichers, Johanna T. W. Wigman, Jessica A. Hartmann
Moving From Static to Dynamic Models of the Onset of Mental Disorder
published pages: 528, ISSN: 2168-622X, DOI: 10.1001/jamapsychiatry.2017.0001
JAMA Psychiatry 74/5 2019-06-18
2017 Fionneke M. Bos, Evelien Snippe, Stijn de Vos, Jessica A. Hartmann, Claudia J.P. Simons, Lian van der Krieke, Peter de Jonge, Marieke Wichers
Can We Jump from Cross-Sectional to Dynamic Interpretations of Networks? Implications for the Network Perspective in Psychiatry
published pages: 175-177, ISSN: 0033-3190, DOI: 10.1159/000453583
Psychotherapy and Psychosomatics 86/3 2019-06-18
2017 Annelie Klippel, Wolfgang Viechtbauer, Ulrich Reininghaus, Johanna Wigman, Claudia van Borkulo, Inez Myin-Germeys, Marieke Wichers
The Cascade of Stress: A Network Approach to Explore Differential Dynamics in Populations Varying in Risk for Psychosis
published pages: , ISSN: 0586-7614, DOI: 10.1093/schbul/sbx037
Schizophrenia Bulletin 2019-06-18
2019 Robin N. Groen, Evelien Snippe, Laura F. Bringmann, Claudia J.P. Simons, Jessica A. Hartmann, Elisabeth H. Bos, Marieke Wichers
Capturing the risk of persisting depressive symptoms: A dynamic network investigation of patients\' daily symptom experiences
published pages: 640-648, ISSN: 0165-1781, DOI: 10.1016/j.psychres.2018.12.054
Psychiatry Research 271 2019-05-10
2019 Marieke Wichers, Marieke J. Schreuder, Rutger Goekoop, Robin N. Groen
Can we predict the direction of sudden shifts in symptoms? Transdiagnostic implications from a complex systems perspective on psychopathology
published pages: 380-387, ISSN: 0033-2917, DOI: 10.1017/s0033291718002064
Psychological Medicine 49/03 2019-05-10

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