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OCLD SIGNED

Tracking the Dynamics of Human Metabolism using Spectroscopy-Integrated Liver-on-Chip Microdevices

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 OCLD project word cloud

Explore the words cloud of the OCLD project. It provides you a very rough idea of what is the project "OCLD" about.

platform    innovative    critical    systemic    optimize    hepatocytes    models    fatty    limited    elucidate    diabetes    continuous    responsible    liver    mechanisms    engineered    chronic    human    stems    tracking    hormonal    pharmaceutical    nutritional    designing    limits    characterization    metabolic    homeostasis    oxygen    relevance    edge    enzymatic    regulation    toxicity    accurate    rationally    deconstruction    stimulation    dynamics    chemical    time    transcriptional    endeavour    regulatory    monitor    drug    assays    intermittent    point    cutting    uniquely    responding    create    infrared    disease    ms    metabolism    organ    reliance    steatosis    tissue    nanosensors    efficient    fast    pharmacokinetics    suited    slow    integrate    replace    preferably    animal    interventions    complexity    rhythms    cells    nanotechnology    diseases    circadian    capitalizes    dosage    dose    minute    pharmacodynamics    resolution    chip    livers    properly    events    microspectroscopy    repeated    invasively   

Project "OCLD" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙118˙175 €
 EC max contribution 2˙118˙175 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 2˙118˙175.00

Map

 Project objective

The liver is the main organ responsible for the systemic regulation of human metabolism, responding to hormonal stimulation, nutritional challenges, and circadian rhythms using fast enzymatic processes and slow transcriptional mechanisms. This regulatory complexity limits our ability to create efficient pharmaceutical interventions for metabolic diseases such as fatty liver disease and diabetes. In addition, circadian changes in drug metabolism can impact pharmacokinetics and pharmacodynamics affecting our ability to optimize drug dosage or properly assess chronic liver toxicity. The challenge in rationally designing efficient drug interventions stems from current reliance on end-point assays and animal models that provide intermittent information with limited human relevance. Therefore, there is a need to develop systems capable of tracking transcriptional and metabolic dynamics of human tissue with high-resolution preferably in real time. Over the past 5 years, we established state-of-the-art models of human hepatocytes; oxygen nanosensors; and cutting-edge liver-on-chip devices, making us uniquely suited to address this challenge. We aim to develop a platform capable of tracking the metabolism of tissue engineered livers in real time, enabling an accurate assessment of chronic liver toxicity (e.g. repeated dose response) and the deconstruction of complex metabolic regulation during nutritional events. Our approach is to integrate liver-on-chip devices, with real time measurements of oxygen uptake, infrared microspectroscopy, and continuous MS/MS analysis. This innovative endeavour capitalizes on advances in nanotechnology and chemical characterization offering the ability to non-invasively monitor the metabolic state of the cells (e.g. steatosis) while tracking minute changes in metabolic pathways. This project has the short-term potential to replace animal models in toxicity studies and long-term potential to elucidate critical aspects in metabolic homeostasis.

 Publications

year authors and title journal last update
List of publications.
2019 Avner Ehrlich, Daniel Duche, Gladys Ouedraogo, Yaakov Nahmias
Challenges and Opportunities in the Design of Liver-on-Chip Microdevices
published pages: 219-239, ISSN: 1523-9829, DOI: 10.1146/annurev-bioeng-060418-052305
Annual Review of Biomedical Engineering 21/1 2020-02-05
2016 Gahl Levy, Naomi Habib, Maria Angela Guzzardi, Daniel Kitsberg, David Bomze, Elishai Ezra, Basak E Uygun, Korkut Uygun, Martin Trippler, Joerg F Schlaak, Oren Shibolet, Ella H Sklan, Merav Cohen, Joerg Timm, Nir Friedman, Yaakov Nahmias
Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection
published pages: 1037-1045, ISSN: 1552-4450, DOI: 10.1038/nchembio.2193
Nature Chemical Biology 12/12 2019-09-04
2018 Avner Ehrlich, Sabina Tsytkin-Kirschenzweig, Konstantinos Ioannidis, Muneef Ayyash, Anne Riu, Reine Note, Gladys Ouedraogo, Jan Vanfleteren, Merav Cohen, Yaakov Nahmias
Microphysiological flux balance platform unravels the dynamics of drug induced steatosis
published pages: 2510-2522, ISSN: 1473-0197, DOI: 10.1039/c8lc00357b
Lab on a Chip 18/17 2019-09-04
2018 Eliezer Keinan, Ayelet Chen Abraham, Aaron Cohen, Alexander I. Alexandrov, Reshef Mintz, Merav Cohen, Dana Reichmann, Daniel Kaganovich, Yaakov Nahmias
High-Reynolds Microfluidic Sorting of Large Yeast Populations
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-31726-6
Scientific Reports 8/1 2019-09-04
2017 Elishai Ezra Tsur, Michal Zimerman, Idan Maor, Avner Elrich, Yaakov Nahmias
Microfluidic Concentric Gradient Generator Design for High-Throughput Cell-Based Studies
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2017.00021
Frontiers in Bioengineering and Biotechnology 5 2019-09-04

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