Explore the words cloud of the Descent project. It provides you a very rough idea of what is the project "Descent" about.
The following table provides information about the project.
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
|Coordinator Country||Switzerland [CH]|
|Total cost||2˙500˙000 €|
|EC max contribution||2˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-09-01 to 2021-08-31|
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|1||FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION||CH (BASEL)||coordinator||2˙500˙000.00|
Movement is the behavioral output of the nervous system. Animals carry out an enormous repertoire of distinct actions, spanning from seemingly simple repetitive tasks like walking to much more complex movements such as forelimb manipulation tasks. An important question is how neuronal circuits are organized and function to choose, maintain, adjust and terminate these many distinct motor behaviors. Recent technological advances in neuroscience have made it possible to begin to unravel the links between the organization of specific neuronal circuit elements in the CNS and the control of movement, a topic that will be central to this research program.
While past work proposes that supraspinal centers in the brainstem are instrumental to the control of action diversification, little is known about how brainstem circuits translate movement intention to body control, how competing motor programs are selected, and how behavioral state influences movement control. The goal of this research project is to unravel the circuit blueprint of mouse descending motor pathways at a fine-scale level and to probe the intersection between revealed circuit organization and their behavioral function at many levels. The focus will be on studies on the interactions between brainstem neurons and spinal circuits to determine how initiation, duration, termination and selection of motor programs are implemented through specific neuronal subpopulations. Mapping descending connectivity matrices of motor circuits will serve as entry point and we will make use of state-of-the art intersectional technology including mouse genetics, viral approaches, in vivo neuronal recordings and activity manipulations of specific neuronal populations during behavior. Together, our project will elucidate the circuit organization and function of the descending motor output system and thereby uncover principles of how the nervous system generates diverse actions.
|year||authors and title||journal||last update|
Aya Takeoka, Silvia Arber
Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury
published pages: 71-85.e3, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.03.010
|Cell Reports 27/1||2019-10-29|
Ludwig Ruder, Silvia Arber
Brainstem Circuits Controlling Action Diversification
published pages: 485-504, ISSN: 0147-006X, DOI: 10.1146/annurev-neuro-070918-050201
|Annual Review of Neuroscience 42/1||2019-10-29|
Organization and function of neuronal circuits controlling movement
published pages: 281-284, ISSN: 1757-4676, DOI: 10.15252/emmm.201607226
|EMBO Molecular Medicine 9/3||2019-06-13|
Jinjin Wu, Paolo Capelli, Julien Bouvier, Martyn Goulding, Silvia Arber, Gilles Fortin
A V0 core neuronal circuit for inspiration
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00589-2
|Nature Communications 8/1||2019-06-13|
Ludwig Ruder, Aya Takeoka, Silvia Arber
Long-Distance Descending Spinal Neurons Ensure Quadrupedal Locomotor Stability
published pages: 1063-1078, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.10.032
Paolo Capelli, Chiara Pivetta, Maria Soledad Esposito, Silvia Arber
Locomotor speed control circuits in the caudal brainstem
published pages: , ISSN: 0028-0836, DOI: 10.1038/nature24064
Manuel J. Ferreira-Pinto, Ludwig Ruder, Paolo Capelli, Silvia Arber
Connecting Circuits for Supraspinal Control of Locomotion
published pages: 361-374, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.09.015
Myungin Baek, Chiara Pivetta, Jeh-Ping Liu, Silvia Arber, Jeremy S. Dasen
Columnar-Intrinsic Cues Shape Premotor Input Specificity in Locomotor Circuits
published pages: 867-877, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.10.004
|Cell Reports 21/4||2019-04-16|
Matthias Heindorf, Silvia Arber, Georg B. Keller
Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback
published pages: 1040-1054.e5, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.07.046
Silvia Arber, Rui M. Costa
Connecting neuronal circuits for movement
published pages: 1403-1404, ISSN: 0036-8075, DOI: 10.1126/science.aat5994
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