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BRCA-ERC SIGNED

Understanding cancer development in BRCA 1/2 mutation carriers for improved Early detection and Risk Control

Total Cost €

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EC-Contrib. €

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Partnership

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 BRCA-ERC project word cloud

Explore the words cloud of the BRCA-ERC project. It provides you a very rough idea of what is the project "BRCA-ERC" about.

identity    interdisciplinary    germline    newly    reducing    ideally    multicellular    scientific    risk    epigenetic    lack    centered    outcome    uncover    cardiovascular    initiating    breakthrough    normal    chronic    largely    samples    controls    brca    pioneering    origin    organs    medical    mutation    mechanistically    clinician    tissues    assembled    mortality    consequently    biologists    epigenome    demonstrates    powerful    brca1    recent    carriers    preventative    linked    efficacy    core    team    ovarian    principles    trigger    buccal    consequence    effect    computational    blood    net    mutations    cancer    monitor    cell    cohort    fundamental    multifactorial    cancers    cervical    direct    diseases    distant    re    possibly    patient    reset    hypothesis    predictors    medicine    screening    breast    cells    placed    neutralise    surgery    applicable    establishing    functionalists    fatal    autonomous    human    scientists    disease    immunologists    overtaking    advocacy    women    extremely    groups   

Project "BRCA-ERC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙497˙841 €
 EC max contribution 2˙497˙841 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 2˙264˙589.00
2    UNIVERSITY COLLEGE LONDON HOSPITALSNHS FOUNDATION TRUST UK (LONDON) participant 233˙251.00

Map

 Project objective

Recent evidence demonstrates that cancer is overtaking cardiovascular disease as the number one cause of mortality in Europe. This is largely due to the lack of preventative measures for common (e.g. breast) or highly fatal (e.g. ovarian) human cancers. Most cancers are multifactorial in origin. The core hypothesis of this research programme is that the extremely high risk of BRCA1/2 germline mutation carriers to develop breast and ovarian cancer is a net consequence of cell-autonomous (direct effect of BRCA mutation in cells at risk) and cell non-autonomous (produced in distant organs and affecting organs at risk) factors which both trigger epigenetic, cancer-initiating effects. The project’s aims are centered around the principles of systems medicine and built on a large cohort of BRCA mutation carriers and controls who will be offered newly established cancer screening programmes. We will uncover how ‘cell non-autonomous’ factors work, provide detail on the epigenetic changes in at-risk tissues and investigate whether these changes are mechanistically linked to cancer, study whether we can neutralise this process and measure success in the organs at risk, and ideally in easy to access samples such as blood, buccal and cervical cells. In my Department for Women’s Cancer we have assembled a powerful interdisciplinary team including computational biologists, functionalists, immunologists and clinician scientists linked to leading patient advocacy groups which is extremely well placed to lead this pioneering project to develop the fundamental understanding of cancer development in women with BRCA mutations. To reset the epigenome, re-establishing normal cell identity and consequently reducing cancer risk without the need for surgery and being able to monitor the efficacy using multicellular epigenetic outcome predictors will be a major scientific and medical breakthrough and possibly applicable to other chronic diseases.

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The information about "BRCA-ERC" are provided by the European Opendata Portal: CORDIS opendata.

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