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BRCA-ERC SIGNED

Understanding cancer development in BRCA 1/2 mutation carriers for improved Early detection and Risk Control

Total Cost €

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EC-Contrib. €

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Partnership

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 BRCA-ERC project word cloud

Explore the words cloud of the BRCA-ERC project. It provides you a very rough idea of what is the project "BRCA-ERC" about.

organs    chronic    establishing    tissues    reset    trigger    medical    fundamental    epigenome    risk    demonstrates    mutations    preventative    human    recent    mechanistically    reducing    direct    breast    women    computational    blood    medicine    extremely    neutralise    disease    cervical    scientists    initiating    mortality    lack    interdisciplinary    functionalists    buccal    immunologists    team    ideally    largely    multicellular    net    scientific    consequence    patient    normal    placed    re    hypothesis    distant    clinician    principles    consequently    centered    multifactorial    pioneering    carriers    overtaking    breakthrough    ovarian    powerful    cancers    brca    fatal    origin    identity    assembled    surgery    applicable    diseases    cancer    uncover    cell    germline    mutation    cells    core    autonomous    groups    outcome    newly    samples    controls    possibly    brca1    effect    screening    epigenetic    efficacy    biologists    cohort    monitor    cardiovascular    linked    advocacy    predictors   

Project "BRCA-ERC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙497˙841 €
 EC max contribution 2˙497˙841 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 2˙264˙589.00
2    UNIVERSITY COLLEGE LONDON HOSPITALSNHS FOUNDATION TRUST UK (LONDON) participant 233˙251.00

Map

 Project objective

Recent evidence demonstrates that cancer is overtaking cardiovascular disease as the number one cause of mortality in Europe. This is largely due to the lack of preventative measures for common (e.g. breast) or highly fatal (e.g. ovarian) human cancers. Most cancers are multifactorial in origin. The core hypothesis of this research programme is that the extremely high risk of BRCA1/2 germline mutation carriers to develop breast and ovarian cancer is a net consequence of cell-autonomous (direct effect of BRCA mutation in cells at risk) and cell non-autonomous (produced in distant organs and affecting organs at risk) factors which both trigger epigenetic, cancer-initiating effects. The project’s aims are centered around the principles of systems medicine and built on a large cohort of BRCA mutation carriers and controls who will be offered newly established cancer screening programmes. We will uncover how ‘cell non-autonomous’ factors work, provide detail on the epigenetic changes in at-risk tissues and investigate whether these changes are mechanistically linked to cancer, study whether we can neutralise this process and measure success in the organs at risk, and ideally in easy to access samples such as blood, buccal and cervical cells. In my Department for Women’s Cancer we have assembled a powerful interdisciplinary team including computational biologists, functionalists, immunologists and clinician scientists linked to leading patient advocacy groups which is extremely well placed to lead this pioneering project to develop the fundamental understanding of cancer development in women with BRCA mutations. To reset the epigenome, re-establishing normal cell identity and consequently reducing cancer risk without the need for surgery and being able to monitor the efficacy using multicellular epigenetic outcome predictors will be a major scientific and medical breakthrough and possibly applicable to other chronic diseases.

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