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LEAPS SIGNED

Light effected autonomous molecular pumps: Towards active transporters and actuating materials

Total Cost €

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EC-Contrib. €

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Partnership

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 LEAPS project word cloud

Explore the words cloud of the LEAPS project. It provides you a very rough idea of what is the project "LEAPS" about.

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Project "LEAPS" data sheet

The following table provides information about the project.

Coordinator
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA 

Organization address
address: VIA ZAMBONI 33
city: BOLOGNA
postcode: 40126
website: www.unibo.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://site.unibo.it/leaps/en
 Total cost 2˙362˙950 €
 EC max contribution 2˙362˙950 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA IT (BOLOGNA) coordinator 2˙362˙950.00

Map

 Project objective

The crucial role played by molecular motors in major biological processes gives a clue on the potential of these nanoscale devices for technology. Their exploitation depends on our ability to build working and robust artificial systems, and to interface them with their environment or other molecular constructs for using the motion to carry out tasks.

The goal of this project is to develop the first synthetic photochemical supramolecular pumps and to apply them for performing nanoscale transport functions and macroscopic actuation. The motor modules, which rely on a functioning and affordable minimalist design based on first principles and threaded topologies, operate autonomously away from equilibrium by using light as a clean energy source, can be switched on/off chemically, and are easy to make and functionalize. Appropriately designed motors will be embedded in the bilayer of vesicles to pump molecules across physically separated places, thereby photogenerating concentration gradients. In parallel we plan to arrange the pump modules in oligomeric tracks and investigate the autonomous, directional and processive displacement of a molecule over a few nm. These linear motors will be equipped with a cargo that can be loaded/unloaded with control, yielding the first man-made molecular transporters. Finally, we will integrate the pump components in polymeric scaffolds such that the photoinduced operation of the motors produces a non-equilibrium entanglement of the polymer chains, that can be eventually unravelled by chemical stimulation. Such materials may be used to convert, store, and reuse the energy of (sun)light upon demand.

All the above functionalities are unprecedented for wholly synthetic chemical structures. Their demonstration would be a landmark result in supramolecular chemistry and nanoscience, and open up radically new directions for nanotechnology, nanomedicine, and energy conversion.

 Publications

year authors and title journal last update
List of publications.
2019 Massimo Baroncini, Jessica Groppi, Stefano Corra, Serena Silvi, Alberto Credi
Light‐Responsive (Supra)Molecular Architectures: Recent Advances
published pages: 1900392, ISSN: 2195-1071, DOI: 10.1002/adom.201900392
Advanced Optical Materials 7/16 2020-02-12
2019 Stefano Corra, Christiaan de Vet, Jessica Groppi, Marcello La Rosa, Serena Silvi, Massimo Baroncini, Alberto Credi
Chemical On/Off Switching of Mechanically Planar Chirality and Chiral Anion Recognition in a [2]Rotaxane Molecular Shuttle
published pages: 9129-9133, ISSN: 0002-7863, DOI: 10.1021/jacs.9b00941
Journal of the American Chemical Society 141/23 2020-02-12
2019 Andrea Sabatino, Emanuele Penocchio, Giulio Ragazzon, Alberto Credi, Diego Frezzato
Individual-Molecule Perspective Analysis of Chemical Reaction Networks: The Case of a Light-Driven Supramolecular Pump
published pages: 14341-14348, ISSN: 1433-7851, DOI: 10.1002/anie.201908026
Angewandte Chemie International Edition 58/40 2020-02-12
2019 Alessandro Iagatti, Baihao Shao, Alberto Credi, Barbara Ventura, Ivan Aprahamian, Mariangela Di Donato
Ultrafast processes triggered by one- and two-photon excitation of a photochromic and luminescent hydrazone
published pages: 2438-2446, ISSN: 1860-5397, DOI: 10.3762/bjoc.15.236
Beilstein Journal of Organic Chemistry 15 2020-02-12
2019 Giorgio Baggi, Lorenzo Casimiro, Massimo Baroncini, Serena Silvi, Alberto Credi, Stephen J. Loeb
Threading-gated photochromism in [2]pseudorotaxanes
published pages: 5104-5113, ISSN: 2041-6520, DOI: 10.1039/C9SC00913B
Chemical Science 10/19 2020-02-12
2019 Massimo Baroncini, Serena Silvi, Alberto Credi
Photo- and Redox-Driven Artificial Molecular Motors
published pages: , ISSN: 0009-2665, DOI: 10.1021/acs.chemrev.9b00291
Chemical Reviews 2020-02-12
2018 Giulio Ragazzon, Christian Schäfer, Paola Franchi, Serena Silvi, Benoit Colasson, Marco Lucarini, Alberto Credi
Remote electrochemical modulation of pK a in a rotaxane by co-conformational allostery
published pages: 201712783, ISSN: 0027-8424, DOI: 10.1073/pnas.1712783115
Proceedings of the National Academy of Sciences 115/38 2020-02-12
2017 Guido Orlandini, Giulio Ragazzon, Valeria Zanichelli, Lorenzo Degli Esposti, Massimo Baroncini, Serena Silvi, Margherita Venturi, Alberto Credi, Andrea Secchi, Arturo Arduini
Plugging a Bipyridinium Axle into Multichromophoric Calix[6]arene Wheels Bearing Naphthyl Units at Different Rims
published pages: 64-72, ISSN: 2191-1363, DOI: 10.1002/open.201600128
ChemistryOpen 6/1 2020-02-12
2018 Lorenzo Casimiro, Jessica Groppi, Massimo Baroncini, Marcello La Rosa, Alberto Credi, Serena Silvi
Photochemical investigation of cyanoazobenzene derivatives as components of artificial supramolecular pumps
published pages: 734-740, ISSN: 1474-905X, DOI: 10.1039/c8pp00062j
Photochemical & Photobiological Sciences 17/6 2020-02-12
2018 Massimo Baroncini, Lorenzo Casimiro, Christiaan de Vet, Jessica Groppi, Serena Silvi, Alberto Credi
Making and Operating Molecular Machines: A Multidisciplinary Challenge
published pages: 169-179, ISSN: 2191-1363, DOI: 10.1002/open.201700181
ChemistryOpen 7/2 2020-02-12
2018 Valeria Zanichelli, Luca Dallacasagrande, Arturo Arduini, Andrea Secchi, Giulio Ragazzon, Serena Silvi, Alberto Credi
Electrochemically Triggered Co-Conformational Switching in a [2]catenane Comprising a Non-Symmetric Calix[6]arene Wheel and a Two-Station Oriented Macrocycle
published pages: 1156, ISSN: 1420-3049, DOI: 10.3390/molecules23051156
Molecules 23/5 2020-02-12
2018 Marcello La Rosa, Sergey A. Denisov, Gediminas Jonusauskas, Nathan D. McClenaghan, Alberto Credi
Designed Long-Lived Emission from CdSe Quantum Dots through Reversible Electronic Energy Transfer with a Surface-Bound Chromophore
published pages: 3104-3107, ISSN: 1433-7851, DOI: 10.1002/anie.201712403
Angewandte Chemie International Edition 57/12 2020-02-12
2018 Christophe Nacci, Massimo Baroncini, Alberto Credi, Leonhard Grill
Reversible Photoswitching and Isomer-Dependent Diffusion of Single Azobenzene Tetramers on a Metal Surface
published pages: 15034-15039, ISSN: 1433-7851, DOI: 10.1002/anie.201806536
Angewandte Chemie International Edition 57/46 2020-02-12
2018 Massimo Baroncini, Martina Canton, Lorenzo Casimiro, Stefano Corra, Jessica Groppi, Marcello La Rosa, Serena Silvi, Alberto Credi
Photoactive Molecular-Based Devices, Machines and Materials: Recent Advances
published pages: 4587-4587, ISSN: 1434-1948, DOI: 10.1002/ejic.201801310
European Journal of Inorganic Chemistry 2018/42 2020-02-12
2018 Baihao Shao, Massimo Baroncini, Hai Qian, Laura Bussotti, Mariangela Di Donato, Alberto Credi, Ivan Aprahamian
Solution and Solid-State Emission Toggling of a Photochromic Hydrazone
published pages: 12323-12327, ISSN: 0002-7863, DOI: 10.1021/jacs.8b07108
Journal of the American Chemical Society 140/39 2020-02-12
2019 Margherita Bazzoni, Valeria Zanichelli, Lorenzo Casimiro, Chiara Massera, Alberto Credi, Andrea Secchi, Serena Silvi, Arturo Arduini
New Geometries for Calix[6]arene-Based Rotaxanes
published pages: in press, ISSN: 1434-193X, DOI: 10.1002/ejoc.201900211
European Journal of Organic Chemistry in press 2020-02-12
2019 Alberto Credi
A Molecular Cable Car for Transmembrane Ion Transport
published pages: 4108-4110, ISSN: 1433-7851, DOI: 10.1002/anie.201814333
Angewandte Chemie International Edition 58/13 2020-02-12

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