EURO-MOTOR

European multidisciplinary ALS network identification to cure motor neuron degeneration

 Coordinatore UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

 Organization address address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX

contact info
Titolo: Prof.
Nome: Leonard
Cognome: Van Den Berg
Email: send email
Telefono: +31 88 7557939
Fax: +31 88 7557939

 Nazionalità Coordinatore Netherlands [NL]
 Sito del progetto http://www.euromotorproject.eu/
 Totale costo 11˙939˙816 €
 EC contributo 8˙994˙361 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2010-two-stage
 Funding Scheme CP-IP
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-02-01   -   2016-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT

 Organization address address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX

contact info
Titolo: Prof.
Nome: Leonard
Cognome: Van Den Berg
Email: send email
Telefono: +31 88 7557939
Fax: +31 88 7557939

NL (UTRECHT) coordinator 2˙008˙334.00
2    IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

 Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ

contact info
Titolo: Ms.
Nome: Tatjana
Cognome: Palalic
Email: send email
Telefono: 442076000000
Fax: +44 2075943868

UK (LONDON) participant 825˙291.60
3    KING'S COLLEGE LONDON

 Organization address address: Strand
city: LONDON
postcode: WC2R 2LS

contact info
Titolo: Prof.
Nome: Ammar
Cognome: Al-Chalabi
Email: send email
Telefono: +44 20 7848 5187
Fax: +44 20 7848 5187

UK (LONDON) participant 785˙457.60
4    VIB

 Organization address address: Rijvisschestraat 120
city: ZWIJNAARDE - GENT
postcode: 9052

contact info
Titolo: Dr.
Nome: Rik
Cognome: Audenaert
Email: send email
Telefono: +32 9 2446611
Fax: +32 9 2446610

BE (ZWIJNAARDE - GENT) participant 753˙000.00
5    THE UNIVERSITY OF SHEFFIELD

 Organization address address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN

contact info
Titolo: Prof.
Nome: Pamela
Cognome: Shaw
Email: send email
Telefono: +44 0 114 271 3017

UK (SHEFFIELD) participant 698˙906.40
6    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Matthias
Cognome: Mann
Email: send email
Telefono: +49 89 8578 2558

DE (MUENCHEN) participant 668˙253.75
7    UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT

 Organization address address: JOSEF-SCHNEIDER-STRASSE 2
city: WUERZBURG
postcode: 97080

contact info
Titolo: Prof.
Nome: Michael
Cognome: Sendtner
Email: send email
Telefono: +49 0931 20144000

DE (WUERZBURG) participant 602˙190.00
8    UNIVERSITY COLLEGE LONDON

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Ms.
Nome: Greta
Cognome: Borg-Carbott
Email: send email
Telefono: 442030000000
Fax: 442078000000

UK (LONDON) participant 507˙386.40
9    UNIVERSITE DE STRASBOURG

 Organization address address: rue Blaise Pascal 4
city: Strasbourg
postcode: 67070

contact info
Titolo: Dr.
Nome: Jean-Philippe
Cognome: Loeffler
Email: send email
Telefono: +33 368 853081

FR (Strasbourg) participant 470˙064.00
10    ACADEMISCH ZIEKENHUIS GRONINGEN

 Organization address address: Hanzeplein 1
city: GRONINGEN
postcode: 9713 GZ

contact info
Titolo: Dr.
Nome: Lude H.
Cognome: Franke
Email: send email
Telefono: +31 50 3617130
Fax: +31 503614351

NL (GRONINGEN) participant 452˙160.00
11    ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI

 Organization address address: Via Giuseppe La Masa 19
city: MILANO
postcode: 20156

contact info
Titolo: Dr.
Nome: Ettore
Cognome: Beghi
Email: send email
Telefono: 390239000000

IT (MILANO) participant 372˙720.00
12    UNIVERSITA DEGLI STUDI DI TORINO

 Organization address address: Via Giuseppe Verdi 8
city: TORINO
postcode: 10124

contact info
Titolo: Dr.
Nome: Adriano
Cognome: Chiò
Email: send email
Telefono: 390116000000

IT (TORINO) participant 316˙632.00
13    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

 Organization address address: College Green -
city: DUBLIN
postcode: 2

contact info
Titolo: Ms.
Nome: Deirdre
Cognome: Savage
Email: send email
Telefono: 35318961942
Fax: 35317071633

IE (DUBLIN) participant 201˙804.00
14    UNIVERSITAET ULM

 Organization address address: HELMHOLTZSTRASSE 16
city: ULM
postcode: 89081

contact info
Titolo: Mr.
Nome: Frank
Cognome: Gleixner
Email: send email
Telefono: +49 73150066397
Fax: +49 73150066392

DE (ULM) participant 193˙200.00
15    ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

 Organization address address: 3 Avenue Victoria
city: PARIS
postcode: 75004

contact info
Titolo: Prof.
Nome: Vincent
Cognome: Meininger
Email: send email
Telefono: +33 680451730
Fax: +33 680451730

FR (PARIS) participant 138˙962.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

models    functional    omics    time    motor    prospective    disease    als    patients    data    patient   

 Obiettivo del progetto (Objective)

'Amyotrophic Lateral Sclerosis is one of the most devastating diseases in neurology affecting in Europe 50,000 individuals at any time, and causing around 10,000 deaths each year. ALS is characterized by progressive degeneration of motor neurons in brain and spinal cord leading to muscle weakness. ALS affects otherwise healthy people at any time in adulthood. The patient becomes paralyzed and dies as the result of respiratory failure on average 3 years after onset of symptoms. There is no cure for ALS. The only available drug (Riluzole) is marginally effective in extending the lifespan of ALS patients with 3 to 6 months. Despite recent scientific breakthroughs in the discovery of (1) multiple ALS associated genes, (2) evidence for metabolic dysregulation, (3) environmental risk factors, and (4) the protein TDP43 in aggregates of 95% of ALS patients, mechanistic models applicable to patients are still unknown. This shows that ALS can best be tackled through a systems biology approach which can only be achieved in a large integrative effort at the European level. Euro-MOTOR unites a multidisciplinary partnership of world-leading experts of clinicians, basic scientists and bioinformaticians, and is able to exploit excellent infrastructures for patient sampling, -omics platforms, disease modelling and bioinformatics. Euro-MOTOR will integrate large quantitative -omics data sets from new functional models and from patients in two prospective European, population-based inception cohorts. By leveraging on the variation in the multilevel -omics data, Euro-MOTOR aims to detect key genetic drivers of disease susceptibility/progression, while parametric modelling of the causal connections in identified molecular networks will generate a model of disease. Major findings will be validated in a second prospective patient cohort and adequate functional models, resulting in robust targets that pave the way for novel therapeutic interventions for this disabling and fatal disease.'

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