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ELOXY SIGNED

Eliminating Oxygen Requirements in Yeasts

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ELOXY project word cloud

Explore the words cloud of the ELOXY project. It provides you a very rough idea of what is the project "ELOXY" about.

anaerobic    sugars    ufa    conversion    notable    synthetic    oxygen    depletion    performance    yeast    huge    transport    ferment    feedstock    unless    producing    industry    theoretical    yeasts    micro    engineering    bulk    experimental    cutting    maxima    organisms    thermotolerance    sterols    fuel    efficiencies    nevertheless    accessed    microbial    genomics    efficient    unsaturated    anaerobically    edge    replacement    eukaryotes    attractive    techniques    acids    saccharomyces    metabolic    consequently    sustainable    question    grow    fermentation    molecular    synthesis    cerevisiae    ufas    fundamental    exception    scientific    share    unidentified    biotechnology    responsible    substrate    fatty    biology    unable    elucidated    ethanol    industrial    quantitative    chemicals    computational    microorganisms    assisted    unprecedented    innovative    limitation    deteriorates    fuels    petrochemistry    integrates    basis    advantages    physiology    species    sterol    platforms    biofuels    fungi   

Project "ELOXY" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT DELFT 

Organization address
address: STEVINWEG 1
city: DELFT
postcode: 2628 CN
website: www.tudelft.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙498˙150 €
 EC max contribution 2˙498˙150 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT DELFT NL (DELFT) coordinator 2˙498˙150.00

Map

 Project objective

Replacement of petrochemistry-based transport fuels and bulk chemicals by industrial biotechnology requires cost-efficient microbial processes, whose feedstock-to-product conversion efficiencies approach theoretical maxima. For many products, such high efficiencies require anaerobic processes and, consequently, industrial microorganisms capable of robust anaerobic growth. Yeasts are robust micro-organisms but, with the notable exception of Saccharomyces species, they share an important limitation with most other eukaryotes: they cannot grow anaerobically.

Even Saccharomyces cerevisiae, the yeast responsible for industrial fuel ethanol production in large-scale anaerobic processes, requires sterols and unsaturated fatty acids (UFAs) for anaerobic growth. Depletion of these anaerobic growth factors deteriorates its fermentation performance. Several ethanol-producing, non-Saccharomyces species have highly attractive properties for industrial application, including a much higher thermotolerance and broader substrate range than S. cerevisiae. However, in addition to sterol and UFA synthesis, these yeasts have other, unidentified oxygen requirements. Unless the molecular basis for these oxygen requirements is elucidated, their huge potential for sustainable production of biofuels and chemicals cannot be accessed by industry.

This proposal addresses the fundamental scientific question why so many yeasts that can ferment sugars to ethanol are nevertheless unable to grow anaerobically. Moreover, by enabling anaerobic growth of non-Saccharomyces yeasts, it aims to build yeast platforms with unprecedented advantages for industrial biotechnology. The proposed innovative approach to these challenges integrates cutting-edge experimental techniques in quantitative physiology and comparative genomics of yeasts and anaerobic fungi, computational modelling, and synthetic-biology-assisted metabolic engineering of different yeast species.

 Publications

year authors and title journal last update
List of publications.
2018 Robert Mans, Jean-Marc G Daran, Jack T Pronk
Under pressure: evolutionary engineering of yeast strains for improved performance in fuels and chemicals production
published pages: 47-56, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2017.10.011
Current Opinion in Biotechnology 50 2019-05-27
2018 Hannes Juergens, Javier A Varela, Arthur R Gorter de Vries, Thomas Perli, Veronica J M Gast, Nikola Y Gyurchev, Arun S Rajkumar, Robert Mans, Jack T Pronk, John P Morrissey, Jean-Marc G Daran
Genome editing in Kluyveromyces and Ogataea yeasts using a broad-host-range Cas9/gRNA co-expression plasmid
published pages: , ISSN: 1567-1364, DOI: 10.1093/femsyr/foy012
FEMS Yeast Research 18/3 2019-05-27

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