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ELOXY SIGNED

Eliminating Oxygen Requirements in Yeasts

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ELOXY project word cloud

Explore the words cloud of the ELOXY project. It provides you a very rough idea of what is the project "ELOXY" about.

transport    fuels    fermentation    computational    substrate    quantitative    feedstock    fundamental    unidentified    petrochemistry    basis    fatty    exception    efficiencies    nevertheless    notable    sterol    unprecedented    experimental    limitation    micro    theoretical    industrial    conversion    elucidated    performance    cutting    unable    saccharomyces    maxima    chemicals    question    attractive    cerevisiae    techniques    sterols    engineering    unsaturated    accessed    species    integrates    responsible    microbial    depletion    consequently    sugars    huge    biology    ethanol    bulk    ufa    molecular    deteriorates    organisms    grow    share    yeasts    oxygen    unless    replacement    producing    synthetic    synthesis    innovative    thermotolerance    biotechnology    platforms    anaerobically    scientific    yeast    ferment    industry    sustainable    anaerobic    metabolic    physiology    eukaryotes    fuel    genomics    edge    acids    assisted    ufas    biofuels    fungi    microorganisms    advantages    efficient   

Project "ELOXY" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT DELFT 

Organization address
address: STEVINWEG 1
city: DELFT
postcode: 2628 CN
website: www.tudelft.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙498˙150 €
 EC max contribution 2˙498˙150 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT DELFT NL (DELFT) coordinator 2˙498˙150.00

Map

 Project objective

Replacement of petrochemistry-based transport fuels and bulk chemicals by industrial biotechnology requires cost-efficient microbial processes, whose feedstock-to-product conversion efficiencies approach theoretical maxima. For many products, such high efficiencies require anaerobic processes and, consequently, industrial microorganisms capable of robust anaerobic growth. Yeasts are robust micro-organisms but, with the notable exception of Saccharomyces species, they share an important limitation with most other eukaryotes: they cannot grow anaerobically.

Even Saccharomyces cerevisiae, the yeast responsible for industrial fuel ethanol production in large-scale anaerobic processes, requires sterols and unsaturated fatty acids (UFAs) for anaerobic growth. Depletion of these anaerobic growth factors deteriorates its fermentation performance. Several ethanol-producing, non-Saccharomyces species have highly attractive properties for industrial application, including a much higher thermotolerance and broader substrate range than S. cerevisiae. However, in addition to sterol and UFA synthesis, these yeasts have other, unidentified oxygen requirements. Unless the molecular basis for these oxygen requirements is elucidated, their huge potential for sustainable production of biofuels and chemicals cannot be accessed by industry.

This proposal addresses the fundamental scientific question why so many yeasts that can ferment sugars to ethanol are nevertheless unable to grow anaerobically. Moreover, by enabling anaerobic growth of non-Saccharomyces yeasts, it aims to build yeast platforms with unprecedented advantages for industrial biotechnology. The proposed innovative approach to these challenges integrates cutting-edge experimental techniques in quantitative physiology and comparative genomics of yeasts and anaerobic fungi, computational modelling, and synthetic-biology-assisted metabolic engineering of different yeast species.

 Publications

year authors and title journal last update
List of publications.
2018 Robert Mans, Jean-Marc G Daran, Jack T Pronk
Under pressure: evolutionary engineering of yeast strains for improved performance in fuels and chemicals production
published pages: 47-56, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2017.10.011
Current Opinion in Biotechnology 50 2019-05-27
2018 Hannes Juergens, Javier A Varela, Arthur R Gorter de Vries, Thomas Perli, Veronica J M Gast, Nikola Y Gyurchev, Arun S Rajkumar, Robert Mans, Jack T Pronk, John P Morrissey, Jean-Marc G Daran
Genome editing in Kluyveromyces and Ogataea yeasts using a broad-host-range Cas9/gRNA co-expression plasmid
published pages: , ISSN: 1567-1364, DOI: 10.1093/femsyr/foy012
FEMS Yeast Research 18/3 2019-05-27

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