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ELOXY SIGNED

Eliminating Oxygen Requirements in Yeasts

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ELOXY project word cloud

Explore the words cloud of the ELOXY project. It provides you a very rough idea of what is the project "ELOXY" about.

microorganisms    platforms    notable    cutting    bulk    computational    depletion    ufa    species    ferment    elucidated    basis    performance    fatty    molecular    genomics    yeast    limitation    unsaturated    conversion    chemicals    accessed    biology    sterol    consequently    synthetic    physiology    question    anaerobic    exception    share    fundamental    micro    yeasts    advantages    ufas    attractive    grow    techniques    edge    fungi    innovative    eukaryotes    industrial    substrate    industry    quantitative    fuel    replacement    feedstock    unable    efficiencies    sterols    fuels    deteriorates    anaerobically    producing    huge    biotechnology    engineering    acids    biofuels    sustainable    oxygen    integrates    thermotolerance    ethanol    efficient    maxima    unidentified    metabolic    synthesis    sugars    saccharomyces    organisms    transport    assisted    unprecedented    cerevisiae    petrochemistry    theoretical    unless    experimental    responsible    nevertheless    microbial    fermentation    scientific   

Project "ELOXY" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT DELFT 

Organization address
address: STEVINWEG 1
city: DELFT
postcode: 2628 CN
website: www.tudelft.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙498˙150 €
 EC max contribution 2˙498˙150 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT DELFT NL (DELFT) coordinator 2˙498˙150.00

Map

 Project objective

Replacement of petrochemistry-based transport fuels and bulk chemicals by industrial biotechnology requires cost-efficient microbial processes, whose feedstock-to-product conversion efficiencies approach theoretical maxima. For many products, such high efficiencies require anaerobic processes and, consequently, industrial microorganisms capable of robust anaerobic growth. Yeasts are robust micro-organisms but, with the notable exception of Saccharomyces species, they share an important limitation with most other eukaryotes: they cannot grow anaerobically.

Even Saccharomyces cerevisiae, the yeast responsible for industrial fuel ethanol production in large-scale anaerobic processes, requires sterols and unsaturated fatty acids (UFAs) for anaerobic growth. Depletion of these anaerobic growth factors deteriorates its fermentation performance. Several ethanol-producing, non-Saccharomyces species have highly attractive properties for industrial application, including a much higher thermotolerance and broader substrate range than S. cerevisiae. However, in addition to sterol and UFA synthesis, these yeasts have other, unidentified oxygen requirements. Unless the molecular basis for these oxygen requirements is elucidated, their huge potential for sustainable production of biofuels and chemicals cannot be accessed by industry.

This proposal addresses the fundamental scientific question why so many yeasts that can ferment sugars to ethanol are nevertheless unable to grow anaerobically. Moreover, by enabling anaerobic growth of non-Saccharomyces yeasts, it aims to build yeast platforms with unprecedented advantages for industrial biotechnology. The proposed innovative approach to these challenges integrates cutting-edge experimental techniques in quantitative physiology and comparative genomics of yeasts and anaerobic fungi, computational modelling, and synthetic-biology-assisted metabolic engineering of different yeast species.

 Publications

year authors and title journal last update
List of publications.
2018 Robert Mans, Jean-Marc G Daran, Jack T Pronk
Under pressure: evolutionary engineering of yeast strains for improved performance in fuels and chemicals production
published pages: 47-56, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2017.10.011
Current Opinion in Biotechnology 50 2019-05-27
2018 Hannes Juergens, Javier A Varela, Arthur R Gorter de Vries, Thomas Perli, Veronica J M Gast, Nikola Y Gyurchev, Arun S Rajkumar, Robert Mans, Jack T Pronk, John P Morrissey, Jean-Marc G Daran
Genome editing in Kluyveromyces and Ogataea yeasts using a broad-host-range Cas9/gRNA co-expression plasmid
published pages: , ISSN: 1567-1364, DOI: 10.1093/femsyr/foy012
FEMS Yeast Research 18/3 2019-05-27

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