NKT IN HERPES

The role of natural killer T cells in the early stages of the herpes simplex virus infection in skin

 Coordinatore KAROLINSKA INSTITUTET 

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Mr.
Nome: Klas
Cognome: Karlsson
Email: send email
Telefono: +46 8 585 824 34
Fax: +46 8 711 76 84

 Nazionalità Coordinatore Sweden [SE]
 Totale costo 179˙588 €
 EC contributo 179˙588 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2007-4-2-IIF
 Funding Scheme MC-IIF
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-01-01   -   2011-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Mr.
Nome: Klas
Cognome: Karlsson
Email: send email
Telefono: +46 8 585 824 34
Fax: +46 8 711 76 84

SE (STOCKHOLM) coordinator 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cellular    ability    microenvironment    infection    simplex    utilised    genital    immune    herpes    responses    skin    hiv    hsv    virus    modulate    examine    vaccine    acquisition    risk    cells    nkt    local   

 Obiettivo del progetto (Objective)

'The aim of this project is to examine how the local skin microenvironment influences the generation of antiviral immune responses following herpes simplex virus type 2 (HSV-2) infection. Genital herpes, caused primarily by HSV-2, has a worldwide prevalence and is the leading cause of genital ulcers. An increasing number of clinical and epidemiological studies indicate that a recent genital HSV-2 infection increases the risk of HIV acquisition and transmission by up to 3-fold. Therefore, further studies that examine the local immune responses to HSV-2 infection are necessary to elucidate the mechanisms of enhanced risk of HIV-1 acquisition and reveal possible strategies for the development of an effective HSV vaccine. Our project will focus in particular on the responses of human natural killer T (NKT) cells, which are poised to respond within hours of activation and can rapidly modulate cellular immune responses. We will examine the ability of NKT cells to respond directly to virus infection and how the virus can affect their function. In addition, we will investigate how cutaneous immune cell types influence NKT cells and their ability to modulate appropriate cellular responses against HSV-2 infection. A three-dimensional organotypic culture model of skin will be utilised to examine these interactions in a physiologically relevant setting, obviating the need for the use of animal models. This study will provide critical information on how the immunomodulatory activities of NKT cells could be utilised as a viable strategy for the enhancement of local virus-specific immunity and thereby develop better genital herpes vaccines.'

Introduzione (Teaser)

European scientists examined the immune responses against herpes simplex virus 2 in the skin microenvironment. Study findings are expected to contribute towards the development of an effective vaccine.

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