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noMAGIC SIGNED

Noninvasive Manipulation of Gating in Ion Channels

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EC-Contrib. €

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Project "noMAGIC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI MILANO 

Organization address
address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122
website: www.unimi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://nomagicproject.eu/
 Total cost 2˙409˙209 €
 EC max contribution 2˙409˙209 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) coordinator 1˙825˙344.00
2    TECHNISCHE UNIVERSITAT DARMSTADT DE (DARMSTADT) participant 583˙865.00

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 Project objective

noMAGIC has the visionary goal of engineering genetically encoded ion channels, which can be remotely controlled (gated) by stimuli that penetrate deep into human tissue without negative side effects. The control over ion channel activity by deep penetrating stimuli will revolutionize research in neurobiology and physiology as it paves the way for remote and genuine non-invasive control of cell activity in vivo. Synthetic channels, which can be gated by magnetic fields (MF), near infrared (NIR) radiation or ultrasound (US) will be engineered in the frame of noMAGIC by three complementary work packages (WP1-3). Design and engineering of the channels will be performed in WP1 by reiterated steps of rational and irrational design, high throughput screening and in vitro and in vivo functional testing. We have identified two sensor modules for MF and NIR radiation, respectively, which will be functionally connected to a channel pore for a remote control of gating. For the US-gated channel we will engineer a channel pore that is maximally responding to local changes in the lipid environment induced by US. Design and engineering of channels will be complemented by a computational approach (WP2), which analyses, from elastic network models, the mechanical connections in the channel pore and which extracts information on the forces, which are required to gate a channel by the three stimuli. The outcome of WP2 will provide general design rules for synthetic channels with implications much beyond the present project. WP3 also contributes to the engineering effort in WP1 by a spectrum of avant-garde spectroscopic methods, which resolve structural changes of the channel proteins under the influence of remote stimuli. These structural insights will greatly advance our understanding of structure/function correlates in composite ion channels and it will inspire the design and engineering of channels, which respond to remote stimuli.

 Publications

year authors and title journal last update
List of publications.
2017 Oliver Rauh, Ulf-Peter Hansen, Sebastian Mach, Andreas J.W. Hartel, Kenneth L. Shepard, Gerhard Thiel, Indra Schroeder
Extended beta distributions open the access to fast gating in bilayer experiments-assigning the voltage-dependent gating to the selectivity filter
published pages: 3850-3860, ISSN: 0014-5793, DOI: 10.1002/1873-3468.12898
FEBS Letters 591/23 2019-08-08
2017 Stephanie Weißgraeber, Andrea Saponaro, Gerhard Thiel, Kay Hamacher
A reduced mechanical model for cAMP-modulated gating in HCN channels
published pages: 40168, ISSN: 2045-2322, DOI: 10.1038/srep40168
Scientific Reports 7 2019-08-08
2017 Andrea saponaro, Alessandro Porro, Antonio Chaves-Sanjuan, Marco Nardini, Oliver Rauh, Gerhard Thiel, Anna Moroni
Fusicoccin Activates KAT1 Channels by Stabilizing their Interaction with 14-3-3- Proteins
published pages: tpc.00375.2017, ISSN: 1040-4651, DOI: 10.1105/tpc.17.00375
The Plant Cell 2019-08-08
2017 Oliver Rauh, Martin Urban, Leonhard M. Henkes, Tobias Winterstein, Timo Greiner, James L. Van Etten, Anna Moroni, Stefan M. Kast, Gerhard Thiel, Indra Schroeder
Identification of Intrahelical Bifurcated H-Bonds as a New Type of Gate in K + Channels
published pages: 7494-7503, ISSN: 0002-7863, DOI: 10.1021/jacs.7b01158
Journal of the American Chemical Society 139/22 2019-08-08
2018 Laura-Marie Winterstein, Kerri Kukovetz, Oliver Rauh, Daniel L. Turman, Christian Braun, Anna Moroni, Indra Schroeder, Gerhard Thiel
Reconstitution and functional characterization of ion channels from nanodiscs in lipid bilayers
published pages: jgp.201711904, ISSN: 0022-1295, DOI: 10.1085/jgp.201711904
The Journal of General Physiology 2019-08-08
2018 Andreas J. W. Hartel, Peijie Ong, Indra Schroeder, M. Hunter Giese, Siddharth Shekar, Oliver B. Clarke, Ran Zalk, Andrew R. Marks, Wayne A. Hendrickson, Kenneth L. Shepard
Single-channel recordings of RyR1 at microsecond resolution in CMOS-suspended membranes
published pages: E1789-E1798, ISSN: 0027-8424, DOI: 10.1073/pnas.1712313115
Proceedings of the National Academy of Sciences 115/8 2019-08-08
2018 Timo Greiner, Anna Moroni, James Van Etten, Gerhard Thiel
Genes for Membrane Transport Proteins: Not So Rare in Viruses
published pages: 456, ISSN: 1999-4915, DOI: 10.3390/v10090456
Viruses 10/9 2019-08-08
2018 Laura Alberio, Andrea Locarno, Andrea Saponaro, Edoardo Romano, Valérie Bercier, Shahad Albadri, Federica Simeoni, Silvia Moleri, Silvia Pelucchi, Alessandro Porro, Elena Marcello, Noemi Barsotti, Kerri Kukovetz, Arjen J. Boender, Andrea Contestabile, Shizhen Luo, Aubin Moutal, Yingshi Ji, Giulia Romani, Monica Beltrame, Filippo Del Bene, Monica Di Luca, Rajesh Khanna, Henry M. Colecraft, Massimo Pasqualetti, Gerhard Thiel, Raffaella Tonini, Anna Moroni
A light-gated potassium channel for sustained neuronal inhibition
published pages: 969-976, ISSN: 1548-7091, DOI: 10.1038/s41592-018-0186-9
Nature Methods 15/11 2019-08-08
2018 Andrea Saponaro, Francesca Cantini, Alessandro Porro, Annalisa Bucchi, Dario DiFrancesco, Vincenzo Maione, Chiara Donadoni, Bianca Introini, Pietro Mesirca, Matteo E Mangoni, Gerhard Thiel, Lucia Banci, Bina Santoro, Anna Moroni
A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.35753
eLife 7 2019-08-08
2018 V. Rondelli, E. Del Favero, P. Brocca, G. Fragneto, M. Trapp, L. Mauri, M.G. Ciampa, G. Romani, C.J. Braun, L. Winterstein, I. Schroeder, G. Thiel, A. Moroni, L. Cantu\'
Directional K + channel insertion in a single phospholipid bilayer: Neutron reflectometry and electrophysiology in the joint exploration of a model membrane functional platform
published pages: 1742-1750, ISSN: 0304-4165, DOI: 10.1016/j.bbagen.2018.05.007
Biochimica et Biophysica Acta (BBA) - General Subjects 1862/8 2019-08-08
2018 Christine Gross, Andrea Saponaro, Bina Santoro, Anna Moroni, Gerhard Thiel, Kay Hamacher
Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide–gated cation channel
published pages: 12908-12918, ISSN: 0021-9258, DOI: 10.1074/jbc.RA118.002139
Journal of Biological Chemistry 293/33 2019-08-08
2018 O. Rauh, U. P. Hansen, D. D. Scheub, G. Thiel, I. Schroeder
Site-specific ion occupation in the selectivity filter causes voltage-dependent gating in a viral K+ channel
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28751-w
Scientific Reports 8/1 2019-08-08

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