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THIRST SIGNED

Third Strategy in Tissue Engineering – Functional microfabricated multicellular spheroid carriers for tissue engineering and regeneration

Total Cost €

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EC-Contrib. €

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Partnership

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 THIRST project word cloud

Explore the words cloud of the THIRST project. It provides you a very rough idea of what is the project "THIRST" about.

applicability    successful    regulatory    enabled    realization    radically    mostly    expanded    desperately    combination    clinical    variety    fairly    despite    bone    box    spheroids    pursues    tissue    thirst    disease    considerable    tissues    sight    protocols    holds    microscaffolds    establishing    fact    strategies    technological    latter    strategy    basic    repair    substantial    engineering    te    universal    restricted    translation    vascularized    overcoming    urgent    cutting    possibilities    few    context    multicellular    automated    edge    nature    launch    hurdles    extremely    demonstrating    fundamental    therapies    interdisciplinary    biofunctionalisation    procedure    microscaffold    breakthrough    cartilage    assembly    scientific    became    printed    organ    seem    relies    types    avascular    noble    modules    focussed    3d    community    expectations    representing    encaged    conventional    solution    inspiring    examples    bottlenecks    tool    area    adjustments    represented    unconventional    self   

Project "THIRST" data sheet

The following table provides information about the project.

Coordinator		 TECHNISCHE UNIVERSITAET WIEN 

Organization address
address: KARLSPLATZ 13
city: WIEN
postcode: 1040
website: www.tuwien.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Austria [AT]
 Total cost 1˙999˙962 €
 EC max contribution 1˙999˙962 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 1˙746˙837.00
2    LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG AT (WIEN) participant 253˙125.00

Map

 Project objective

The field of tissue engineering (TE) pursues a noble goal, driven by the urgent need for tissue and organ repair. It is represented by a fairly large and extremely interdisciplinary scientific community. However, so far TE was not able to deliver to the expectations, with only a few examples of successful clinical translation mostly restricted to a particular disease or tissue type. Despite the fact that all major fundamental bottlenecks of conventional TE strategies have long been identified, a universal solution does not seem to be in sight. In this project I propose to launch a radically new approach, a third strategy in tissue engineering (THIRST), which holds the potential to produce a desperately needed technological breakthrough. THIRST relies on a tissue self-assembly from multicellular spheroids encaged within robust 3D printed microscaffolds. THIRST is enabled by a number of cutting-edge methods, some of which became relevant in the context of TE only recently. In combination, these methods offer a variety of new technological possibilities for the area of TE. The objectives of this project are focussed on establishing the means for automated large-scale production of tissue modules, protocols for microscaffold biofunctionalisation, and demonstrating THIRST potential with highly relevant clinical examples - cartilage, representing avascular tissue, and vascularized bone tissue. A distinct feature of THIRST is its universal applicability, meaning that such a tool-box can be further expanded to encompass other types of tissues without substantial adjustments to the basic tissue assembly procedure. The latter is particularly inspiring, taking into account the considerable regulatory hurdles associated with the development of new TE therapies. Due to its unconventional nature, realization of THIRST relies on overcoming several considerable technological challenges addressed by this project.

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The information about "THIRST" are provided by the European Opendata Portal: CORDIS opendata.

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