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Third Strategy in Tissue Engineering – Functional microfabricated multicellular spheroid carriers for tissue engineering and regeneration

Total Cost €


EC-Contrib. €






 THIRST project word cloud

Explore the words cloud of the THIRST project. It provides you a very rough idea of what is the project "THIRST" about.

encaged    despite    relies    avascular    latter    enabled    disease    expectations    translation    urgent    organ    successful    area    cartilage    conventional    fundamental    pursues    breakthrough    considerable    nature    scientific    represented    representing    possibilities    inspiring    desperately    basic    interdisciplinary    focussed    biofunctionalisation    bone    extremely    multicellular    printed    combination    fact    substantial    fairly    procedure    hurdles    cutting    sight    microscaffolds    expanded    variety    tissue    vascularized    solution    therapies    restricted    te    bottlenecks    unconventional    overcoming    spheroids    radically    strategies    self    modules    launch    establishing    seem    clinical    community    demonstrating    regulatory    examples    tissues    mostly    applicability    microscaffold    few    engineering    edge    noble    context    strategy    thirst    tool    3d    protocols    repair    box    universal    types    realization    automated    became    adjustments    technological    assembly    holds   

Project "THIRST" data sheet

The following table provides information about the project.


Organization address
address: KARLSPLATZ 13
city: WIEN
postcode: 1040

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙999˙962 €
 EC max contribution 1˙999˙962 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 1˙746˙837.00


 Project objective

The field of tissue engineering (TE) pursues a noble goal, driven by the urgent need for tissue and organ repair. It is represented by a fairly large and extremely interdisciplinary scientific community. However, so far TE was not able to deliver to the expectations, with only a few examples of successful clinical translation mostly restricted to a particular disease or tissue type. Despite the fact that all major fundamental bottlenecks of conventional TE strategies have long been identified, a universal solution does not seem to be in sight. In this project I propose to launch a radically new approach, a third strategy in tissue engineering (THIRST), which holds the potential to produce a desperately needed technological breakthrough. THIRST relies on a tissue self-assembly from multicellular spheroids encaged within robust 3D printed microscaffolds. THIRST is enabled by a number of cutting-edge methods, some of which became relevant in the context of TE only recently. In combination, these methods offer a variety of new technological possibilities for the area of TE. The objectives of this project are focussed on establishing the means for automated large-scale production of tissue modules, protocols for microscaffold biofunctionalisation, and demonstrating THIRST potential with highly relevant clinical examples - cartilage, representing avascular tissue, and vascularized bone tissue. A distinct feature of THIRST is its universal applicability, meaning that such a tool-box can be further expanded to encompass other types of tissues without substantial adjustments to the basic tissue assembly procedure. The latter is particularly inspiring, taking into account the considerable regulatory hurdles associated with the development of new TE therapies. Due to its unconventional nature, realization of THIRST relies on overcoming several considerable technological challenges addressed by this project.

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The information about "THIRST" are provided by the European Opendata Portal: CORDIS opendata.

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