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IMMUNOALZHEIMER SIGNED

The role of immune cells in Alzheimer's disease

Total Cost €

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EC-Contrib. €

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Partnership

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 IMMUNOALZHEIMER project word cloud

Explore the words cloud of the IMMUNOALZHEIMER project. It provides you a very rough idea of what is the project "IMMUNOALZHEIMER" about.

amyloid    strategies    resident    symptoms    samples    immunoalzheimer    determined    effect    leukocyte    microcirculation    prevalence    aggregates    disease    neurocentric    patients    social    fundamental    protein    tau    circulating    view    pathogenesis    cns    leukocytes    therapeutic    nervous    neurons    immune    cure    form    inflammation    first    functions    economical    modifying    models    society    photon    unexpected    temporarily    cognitive    innovative    interactions    neuropathological    inside    double    tremendous    trafficking    suggests    35    alzheimer    crosstalk    shown    blockade    nearly    beta    mechanisms    neurodegeneration    dynamic    projected    worldwide    intravital    million    generate    progressive    central    team    microscopy    drugs    hyperphosphorylated    experiments    idea    migrating    parenchyma    ed    endothelial    dependent    therapies    supporting    deterioration    dementia    cells    efforts    decades    people    neutrophils    deposition    unveil    brain    animal   

Project "IMMUNOALZHEIMER" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI VERONA 

Organization address
address: VIA DELL ARTIGLIERE 8
city: VERONA
postcode: 37129
website: www.univr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://dp.univr.it/
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI VERONA IT (VERONA) coordinator 2˙500˙000.00

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 Project objective

'Alzheimer’s disease is the most common form of dementia affecting more than 35 million people worldwide and its prevalence is projected to nearly double every 20 years with tremendous social and economical impact on the society. There is no cure for Alzheimer's disease and current drugs only temporarily improve disease symptoms. Alzheimer's disease is characterized by a progressive deterioration of cognitive functions, and the neuropathological features include amyloid beta deposition, aggregates of hyperphosphorylated tau protein, and the loss of neurons in the central nervous system (CNS). Research efforts in the past decades have been focused on neurons and other CNS resident cells, but this 'neurocentric' view has not resulted in disease-modifying therapies. Growing evidence suggests that inflammation mechanisms are involved in Alzheimer's disease and our team has recently shown an unexpected role for neutrophils in Alzheimer's disease, supporting the innovative idea that circulating leukocytes contribute to disease pathogenesis. The main goal of this project is to study the role of immune cells in animal models of Alzheimer's disease focusing on neutrophils and T cells. We will first study leukocyte-endothelial interactions in CNS microcirculation in intravital microscopy experiments. Leukocyte trafficking will be then studied inside the brain parenchyma by using two-photon microscopy, which will allow us to characterize leukocyte dynamic behaviour and the crosstalk between migrating leukocytes and CNS cells. The effect of therapeutic blockade of leukocyte-dependent inflammation mechanisms will be determined in animal models of Alzheimer's disease. Finally, the presence of immune cells will be studied on brain samples from Alzheimer's disease patients. Overall, IMMUNOALZHEIMER will generate fundamental knowledge to the understanding of the role of immune cells in neurodegeneration and will unveil novel therapeutic strategies to address Alzheimer’s disease.'

 Publications

year authors and title journal last update
List of publications.
2016 Rossi, Barbara; Constantin, Gabriela
Live Imaging of Immune Responses in Experimental Models of Multiple Sclerosis
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2016.00506/full
Frontiers in Immunology, Vol 7 (2016) 2 2019-06-13
2017 Elena Zenaro, Gennj Piacentino, Gabriela Constantin
The blood-brain barrier in Alzheimer\'s disease
published pages: 41-56, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2016.07.007
Neurobiology of Disease 107 2019-06-13
2017 Enrica Caterina Pietronigro, Vittorina Della Bianca, Elena Zenaro, Gabriela Constantin
NETosis in Alzheimer’s Disease
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00211
Frontiers in Immunology 8 2019-06-13
2018 Alessia Farinazzo, Stefano Angiari, Ermanna Turano, Edoardo Bistaffa, Silvia Dusi, Serena Ruggieri, Roberta Bonafede, Raffaella Mariotti, Gabriela Constantin, Bruno Bonetti
Nanovesicles from adipose-derived mesenchymal stem cells inhibit T lymphocyte trafficking and ameliorate chronic experimental autoimmune encephalomyelitis
published pages: 1-11, ISSN: 2045-2322, DOI: 10.1038/s41598-018-25676-2
Scientific Reports 8/1 2019-05-27

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The information about "IMMUNOALZHEIMER" are provided by the European Opendata Portal: CORDIS opendata.

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