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The role of immune cells in Alzheimer's disease

Total Cost €


EC-Contrib. €






 IMMUNOALZHEIMER project word cloud

Explore the words cloud of the IMMUNOALZHEIMER project. It provides you a very rough idea of what is the project "IMMUNOALZHEIMER" about.

disease    progressive    photon    alzheimer    amyloid    migrating    blockade    society    inside    decades    strategies    protein    unexpected    supporting    projected    worldwide    hyperphosphorylated    nearly    form    prevalence    generate    neurons    therapeutic    neuropathological    35    social    temporarily    resident    endothelial    mechanisms    neurocentric    dementia    million    neutrophils    suggests    interactions    symptoms    cure    innovative    aggregates    animal    leukocytes    ed    double    modifying    people    economical    nervous    patients    therapies    immunoalzheimer    pathogenesis    crosstalk    leukocyte    central    unveil    dependent    immune    deposition    brain    fundamental    dynamic    cognitive    deterioration    efforts    models    neurodegeneration    experiments    effect    trafficking    determined    team    functions    tau    shown    cns    intravital    inflammation    microscopy    cells    first    tremendous    parenchyma    beta    microcirculation    idea    samples    drugs    view    circulating   

Project "IMMUNOALZHEIMER" data sheet

The following table provides information about the project.


Organization address
city: VERONA
postcode: 37129

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI VERONA IT (VERONA) coordinator 2˙500˙000.00


 Project objective

'Alzheimer’s disease is the most common form of dementia affecting more than 35 million people worldwide and its prevalence is projected to nearly double every 20 years with tremendous social and economical impact on the society. There is no cure for Alzheimer's disease and current drugs only temporarily improve disease symptoms. Alzheimer's disease is characterized by a progressive deterioration of cognitive functions, and the neuropathological features include amyloid beta deposition, aggregates of hyperphosphorylated tau protein, and the loss of neurons in the central nervous system (CNS). Research efforts in the past decades have been focused on neurons and other CNS resident cells, but this 'neurocentric' view has not resulted in disease-modifying therapies. Growing evidence suggests that inflammation mechanisms are involved in Alzheimer's disease and our team has recently shown an unexpected role for neutrophils in Alzheimer's disease, supporting the innovative idea that circulating leukocytes contribute to disease pathogenesis. The main goal of this project is to study the role of immune cells in animal models of Alzheimer's disease focusing on neutrophils and T cells. We will first study leukocyte-endothelial interactions in CNS microcirculation in intravital microscopy experiments. Leukocyte trafficking will be then studied inside the brain parenchyma by using two-photon microscopy, which will allow us to characterize leukocyte dynamic behaviour and the crosstalk between migrating leukocytes and CNS cells. The effect of therapeutic blockade of leukocyte-dependent inflammation mechanisms will be determined in animal models of Alzheimer's disease. Finally, the presence of immune cells will be studied on brain samples from Alzheimer's disease patients. Overall, IMMUNOALZHEIMER will generate fundamental knowledge to the understanding of the role of immune cells in neurodegeneration and will unveil novel therapeutic strategies to address Alzheimer’s disease.'


year authors and title journal last update
List of publications.
2016 Rossi, Barbara; Constantin, Gabriela
Live Imaging of Immune Responses in Experimental Models of Multiple Sclerosis
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2016.00506/full
Frontiers in Immunology, Vol 7 (2016) 2 2019-06-13
2017 Elena Zenaro, Gennj Piacentino, Gabriela Constantin
The blood-brain barrier in Alzheimer\'s disease
published pages: 41-56, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2016.07.007
Neurobiology of Disease 107 2019-06-13
2017 Enrica Caterina Pietronigro, Vittorina Della Bianca, Elena Zenaro, Gabriela Constantin
NETosis in Alzheimer’s Disease
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00211
Frontiers in Immunology 8 2019-06-13
2018 Alessia Farinazzo, Stefano Angiari, Ermanna Turano, Edoardo Bistaffa, Silvia Dusi, Serena Ruggieri, Roberta Bonafede, Raffaella Mariotti, Gabriela Constantin, Bruno Bonetti
Nanovesicles from adipose-derived mesenchymal stem cells inhibit T lymphocyte trafficking and ameliorate chronic experimental autoimmune encephalomyelitis
published pages: 1-11, ISSN: 2045-2322, DOI: 10.1038/s41598-018-25676-2
Scientific Reports 8/1 2019-05-27

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