Opendata, web and dolomites

IMMUNOALZHEIMER SIGNED

The role of immune cells in Alzheimer's disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 IMMUNOALZHEIMER project word cloud

Explore the words cloud of the IMMUNOALZHEIMER project. It provides you a very rough idea of what is the project "IMMUNOALZHEIMER" about.

deterioration    dependent    cure    unexpected    therapies    blockade    idea    neuropathological    inflammation    35    nervous    generate    leukocytes    interactions    aggregates    prevalence    neurons    patients    projected    photon    modifying    migrating    trafficking    neurocentric    neurodegeneration    determined    innovative    protein    disease    microcirculation    beta    decades    microscopy    resident    experiments    samples    worldwide    central    intravital    double    dementia    social    nearly    ed    strategies    cns    fundamental    inside    models    mechanisms    people    society    circulating    brain    first    leukocyte    form    amyloid    unveil    supporting    efforts    pathogenesis    team    crosstalk    temporarily    neutrophils    tau    therapeutic    effect    immune    cognitive    view    parenchyma    symptoms    hyperphosphorylated    economical    tremendous    functions    endothelial    progressive    drugs    suggests    shown    animal    immunoalzheimer    alzheimer    cells    dynamic    deposition    million   

Project "IMMUNOALZHEIMER" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI VERONA 

Organization address
address: VIA DELL ARTIGLIERE 8
city: VERONA
postcode: 37129
website: www.univr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://dp.univr.it/
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI VERONA IT (VERONA) coordinator 2˙500˙000.00

Map

 Project objective

'Alzheimer’s disease is the most common form of dementia affecting more than 35 million people worldwide and its prevalence is projected to nearly double every 20 years with tremendous social and economical impact on the society. There is no cure for Alzheimer's disease and current drugs only temporarily improve disease symptoms. Alzheimer's disease is characterized by a progressive deterioration of cognitive functions, and the neuropathological features include amyloid beta deposition, aggregates of hyperphosphorylated tau protein, and the loss of neurons in the central nervous system (CNS). Research efforts in the past decades have been focused on neurons and other CNS resident cells, but this 'neurocentric' view has not resulted in disease-modifying therapies. Growing evidence suggests that inflammation mechanisms are involved in Alzheimer's disease and our team has recently shown an unexpected role for neutrophils in Alzheimer's disease, supporting the innovative idea that circulating leukocytes contribute to disease pathogenesis. The main goal of this project is to study the role of immune cells in animal models of Alzheimer's disease focusing on neutrophils and T cells. We will first study leukocyte-endothelial interactions in CNS microcirculation in intravital microscopy experiments. Leukocyte trafficking will be then studied inside the brain parenchyma by using two-photon microscopy, which will allow us to characterize leukocyte dynamic behaviour and the crosstalk between migrating leukocytes and CNS cells. The effect of therapeutic blockade of leukocyte-dependent inflammation mechanisms will be determined in animal models of Alzheimer's disease. Finally, the presence of immune cells will be studied on brain samples from Alzheimer's disease patients. Overall, IMMUNOALZHEIMER will generate fundamental knowledge to the understanding of the role of immune cells in neurodegeneration and will unveil novel therapeutic strategies to address Alzheimer’s disease.'

 Publications

year authors and title journal last update
List of publications.
2016 Rossi, Barbara; Constantin, Gabriela
Live Imaging of Immune Responses in Experimental Models of Multiple Sclerosis
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2016.00506/full
Frontiers in Immunology, Vol 7 (2016) 2 2019-06-13
2017 Elena Zenaro, Gennj Piacentino, Gabriela Constantin
The blood-brain barrier in Alzheimer\'s disease
published pages: 41-56, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2016.07.007
Neurobiology of Disease 107 2019-06-13
2017 Enrica Caterina Pietronigro, Vittorina Della Bianca, Elena Zenaro, Gabriela Constantin
NETosis in Alzheimer’s Disease
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00211
Frontiers in Immunology 8 2019-06-13
2018 Alessia Farinazzo, Stefano Angiari, Ermanna Turano, Edoardo Bistaffa, Silvia Dusi, Serena Ruggieri, Roberta Bonafede, Raffaella Mariotti, Gabriela Constantin, Bruno Bonetti
Nanovesicles from adipose-derived mesenchymal stem cells inhibit T lymphocyte trafficking and ameliorate chronic experimental autoimmune encephalomyelitis
published pages: 1-11, ISSN: 2045-2322, DOI: 10.1038/s41598-018-25676-2
Scientific Reports 8/1 2019-05-27

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IMMUNOALZHEIMER" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IMMUNOALZHEIMER" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

EVOCELFATE (2019)

Evolution of cell fate specification modes in spiral cleavage

Read More  

HydroLieve (2018)

A long-lasting non-migrating hydrogel for relieving chronic pain

Read More  

inSight (2019)

Moving a novel gene therapy paradigm to treat blindness to the market

Read More