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3DPLASTICITY

Plasticity of dendritic computations during active network states

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 3DPLASTICITY project word cloud

Explore the words cloud of the 3DPLASTICITY project. It provides you a very rough idea of what is the project "3DPLASTICITY" about.

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Project "3DPLASTICITY" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://silverlab.org/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2019-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

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 Project objective

Neurons in the cortex generate sensory perceptions by extracting certain features from the environment and combining them with internally generated information. A better understanding of how neurons perform these computations will deepen our understanding of normal brain function and potentially identify novel therapies for mental conditions that perturb sensory perception such as autism, schizophrenia, and epilepsy. Neuronal computations occur at thousands of synapses across three dimensionally complex dendritic trees. In the cortex, dendritic integration takes place in the context of ongoing network activity, and recent work indicates that network activity profoundly alters how neurons compute sensory information. Yet, most of our current knowledge of how dendrites process synaptic inputs has been derived under non-physiological conditions, resulting in a poor understanding of network behavior in the living brain. An equally important property of cortical microcircuits is that they are endowed with a plethora of plasticity mechanisms that enable flexible adaptions to the environment. The role of synaptic plasticity at excitatory synapses is established for such adaptations. How inhibitory plasticity shapes dendritic integration and sensory processing remains largely unexplored. The purpose of my Marie Skłodowska-Curie Individual Fellowship is to elucidate how synaptic plasticity operates within active neuronal networks and how plasticity influences cortical computations within morphologically complex dendritic trees. To address these knowledge gaps, I will combine my expertise in synaptic plasticity, electrophysiology, and pharmacology with cutting-edge techniques I will learn under the mentorship of Professor Angus Silver including 3D imaging, optogenetic applications, and biologically detailed computer modelling. This cutting-edge training-through-research program is expected to transform our understanding of how single neurons compute sensory information.

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The information about "3DPLASTICITY" are provided by the European Opendata Portal: CORDIS opendata.

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