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Novel multimodal approach to atrial fibrillation risk assessment and identification of targets for prevention by interdisciplinary exploitation of omics, advanced electrocardiography, and imaging

Total Cost €


EC-Contrib. €






 MMAF project word cloud

Explore the words cloud of the MMAF project. It provides you a very rough idea of what is the project "MMAF" about.

insights    edge    atrial    accumulated    discrimination    potentially    af    urgently    remodelling    integration    schemes    electrical    translation    gender    omics    fibrillation    metabolomics    explains    efforts       permit    structural    tissue    subclinical    clinical    validated    60    strategies    blood    biobank    individualized    discover    tone    ground    epidemic    prospective    innovative    epidemiologic    cutting    international    risk    lay    ideally    phenotypes    mri    public    enhanced    team    rapid    groups    intermediate    interdisciplinary    contemporary    autonomous    imaging    inflammation    systematically    proteomics    attributable    despite    multimodal    informed    cardiac    choose    disease    suited    imminent    oxidative    pathophysiological    biological    there    electrocardiography    algorithm    highlight    reversible    first    cohorts    stress    scant    manifest    chronic    intervention    population    scheme    pathophysiology    genomics    prevention    treatment    representative    independent    stages    expression    health    echocardiography    tools    collected    markers    incident    complementary    gt    prediction    biology    primary   

Project "MMAF" data sheet

The following table provides information about the project.


Organization address
address: Martinistrasse 52
postcode: 20251

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 1˙999˙305 €
 EC max contribution 1˙999˙305 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

There is a growing need for novel risk schemes in atrial fibrillation (AF) to permit prevention, contribute to a better understanding of the pathophysiology, and discover targets for individualized treatment. Primary prevention efforts are scant despite the imminent AF epidemic. In international cohorts I have developed and validated the first risk prediction algorithm. However, it explains only 60% of the attributable risk and efforts at improving discrimination are urgently required. Therefore, my overall goal is to develop an enhanced risk prediction algorithm based on cutting-edge technology. The specific focus will be on parameters representative of early stages of the disease process and intermediate phenotypes such as atrial electrical and structural remodelling, chronic subclinical inflammation, oxidative stress, and autonomous tone in manifest and incident AF. Subclinical, potentially reversible changes are ideally suited to provide independent information complementary to known risk markers. My ambitious concept is to choose a multimodal approach in an interdisciplinary team to systematically assess: 1) Blood and tissue omics (genomics, expression, proteomics, metabolomics), 2) Advanced electrocardiography, 3) Imaging (echocardiography, cardiac MRI), and 4) Gender applying innovative tools and analyses strategies aimed at a systems biology integration of the accumulated information. I have collected comprehensive biological and epidemiologic information on distinct AF phenotypes in unique prospective population (N>60,000) and clinical cohorts (N>1,000). We are not aware of other groups with access to such a well-established prospective AF biobank. Informed by omics, electrocardiography and imaging we will provide pathophysiological insights into the disease process, highlight targets for intervention, and develop a contemporary risk scheme. Our results will lay the ground for rapid translation into clinical practice with significant public health impact.


year authors and title journal last update
List of publications.
2018 Nils Arne Sörensen, Johannes Tobias Neumann, Francisco Ojeda, Sarina Schäfer, Christina Magnussen, Till Keller, Karl J. Lackner, Tanja Zeller, Mahir Karakas, Thomas Münzel, Stefan Blankenberg, Dirk Westermann, Renate B. Schnabel
Relations of Sex to Diagnosis and Outcomes in Acute Coronary Syndrome
published pages: e007297, ISSN: 2047-9980, DOI: 10.1161/JAHA.117.007297
Journal of the American Heart Association 7/6 2019-06-06
2018 Renate B. Schnabel, Ladislav Pecen, Nargiz Rzayeva, Markus Lucerna, Yanish Purmah, Francisco M. Ojeda, Raffaele De Caterina, Paulus Kirchhof
Symptom Burden of Atrial Fibrillation and Its Relation to Interventions and Outcome in Europe
published pages: e007559, ISSN: 2047-9980, DOI: 10.1161/JAHA.117.007559
Journal of the American Heart Association 7/11 2019-06-06
2016 Renate B. Schnabel, Renke Maas, Na Wang, Xiaoyan Yin, Martin G. Larson, Daniel Levy, Patrick T. Ellinor, Steven A. Lubitz, David D. McManus, Jared W. Magnani, Dorothee Atzler, Rainer H. Böger, Edzard Schwedhelm, Ramachandran S. Vasan, Emelia J. Benjamin
Asymmetric dimethylarginine, related arginine derivatives, and incident atrial fibrillation
published pages: 100-106, ISSN: 0002-8703, DOI: 10.1016/j.ahj.2016.03.007
American Heart Journal 176 2019-06-06
2018 Christoph Niekamp, Dorothee Atzler, Francisco Ojeda, Christoph Sinning, Karl Lackner, Rainer Böger, Thomas Munzel, Manfred Beutel, Irene Schmidtmann, Norbert Pfeiffer, Anja Leuschner, Stefan Blankenberg, Philipp Wild, Tanja Zeller, Edzard Schwedhelm, Renate Schnabel
Cross-Sectional Associations between Homoarginine, Intermediate Phenotypes, and Atrial Fibrillation in the Community—The Gutenberg Health Study
published pages: 86, ISSN: 2218-273X, DOI: 10.3390/biom8030086
Biomolecules 8/3 2019-06-06
2018 Christina Magnussen, Alexander M. Bernhardt, Francisco M. Ojeda, Florian M. Wagner, Jan Gummert, Theo M.M.H. de By, Thomas Krabatsch, Paul Mohacsi, Meike Rybczynski, Dorit Knappe, Bjoern Sill, Tobias Deuse, Stefan Blankenberg, Renate B. Schnabel, Hermann Reichenspurner
Gender differences and outcomes in left ventricular assist device support: The European Registry for Patients with Mechanical Circulatory Support
published pages: 61-70, ISSN: 1053-2498, DOI: 10.1016/j.healun.2017.06.016
The Journal of Heart and Lung Transplantation 37/1 2019-06-06
2018 Christina Magnussen, Francisco M. Ojeda, Renate B. Schnabel
Response by Magnussen et al to Letter Regarding Article, “Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe)”
published pages: 2087-2088, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.118.033968
Circulation 137/19 2019-06-06
2018 Christina Magnussen, Francisco M. Ojeda, Philipp S. Wild, Nils Sörensen, Thomas Rostock, Boris A. Hoffmann, Jürgen Prochaska, Karl J. Lackner, Manfred E. Beutel, Maria Blettner, Norbert Pfeiffer, Nargiz Rzayeva, Christoph R. Sinning, Stefan Blankenberg, Thomas Münzel, Tanja Zeller, Renate B. Schnabel
Atrial Fibrillation Manifestations Risk Factors and Sex Differences in a Population-Based Cohort (From the Gutenberg Health Study)
published pages: 76-82, ISSN: 0002-9149, DOI: 10.1016/j.amjcard.2018.03.028
The American Journal of Cardiology 122/1 2019-06-06
2017 Darae Ko, Renate B. Schnabel, Ludovic Trinquart, Emelia J. Benjamin
The Changing Landscape of Atrial Fibrillation
published pages: 561-564, ISSN: 2213-1779, DOI: 10.1016/j.jchf.2017.05.002
JACC: Heart Failure 5/8 2019-06-06
2016 Darae Ko, Faisal Rahman, Renate B. Schnabel, Xiaoyan Yin, Emelia J. Benjamin, Ingrid E. Christophersen
Atrial fibrillation in women: epidemiology, pathophysiology, presentation and prognosis
published pages: 321-332, ISSN: 1759-5002, DOI: 10.1038/nrcardio.2016.45
Nature Reviews Cardiology 13/6 2019-06-06
2017 Darae Ko, Faisal Rahman, Maria A. P. Martins, Elaine M. Hylek, Patrick T. Ellinor, Renate B. Schnabel, Emelia J. Benjamin, Ingrid E. Christophersen
Atrial fibrillation in women: treatment
published pages: 113-124, ISSN: 1759-5002, DOI: 10.1038/nrcardio.2016.171
Nature Reviews Cardiology 14/2 2019-06-06
2016 Paulus Kirchhof, Günter Breithardt, Jeroen Bax, Gerlinde Benninger, Carina Blomstrom-Lundqvist, Giuseppe Boriani, Axel Brandes, Helen Brown, Martina Brueckmann, Hugh Calkins, Melanie Calvert, Vincent Christoffels, Harry Crijns, Dobromir Dobrev, Patrick Ellinor, Larissa Fabritz, Thomas Fetsch, S. Ben Freedman, Andrea Gerth, Andreas Goette, Eduard Guasch, Guido Hack, Laurent Haegeli, Stephane Hatem, Karl Georg Haeusler, Hein Heidbüchel, Jutta Heinrich-Nols, Francoise Hidden-Lucet, Gerd Hindricks, Steen Juul-Möller, Stefan Kääb, Lukas Kappenberger, Stefanie Kespohl, Dipak Kotecha, Deirdre A. Lane, Angelika Leute, Thorsten Lewalter, Ralf Meyer, Lluis Mont, Felix Münzel, Michael Nabauer, Jens C. Nielsen, Michael Oeff, Jonas Oldgren, Ali Oto, Jonathan P. Piccini, Art Pilmeyer, Tatjana Potpara, Ursula Ravens, Holger Reinecke, Thomas Rostock, Joerg Rustige, Irene Savelieva, Renate Schnabel, Ulrich Schotten, Lars Schwichtenberg, Moritz F. Sinner, Gerhard Steinbeck, Monika Stoll, Luigi Tavazzi, Sakis Themistoclakis, Hung Fat Tse, Isabelle C. Van Gelder, Panagiotis E. Vardas, Timo Varpula, Alphons Vincent, David Werring, Stephan Willems, André Ziegler, Gregory Y.H. Lip, A. John Camm
A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference
published pages: 37-50, ISSN: 1099-5129, DOI: 10.1093/europace/euv304
Europace 18/1 2019-06-06
2017 Christina Magnussen, Teemu J. Niiranen, Francisco M. Ojeda, Francesco Gianfagna, Stefan Blankenberg, Inger Njølstad, Erkki Vartiainen, Susana Sans, Gerard Pasterkamp, Maria Hughes, Simona Costanzo, Maria Benedetta Donati, Pekka Jousilahti, Allan Linneberg, Tarja Palosaari, Giovanni de Gaetano, Martin Bobak, Hester M. den Ruijter, Ellisiv Mathiesen, Torben Jørgensen, Stefan Söderberg, Kari Kuulasmaa, Tanja Zeller, Licia Iacoviello, Veikko Salomaa, Renate B. Schnabel
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts
published pages: 1588-1597, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.117.028981
Circulation 136/17 2019-06-06
2016 Darae Ko, Eric M. Riles, Ernaldo G. Marcos, Jared W. Magnani, Steven A. Lubitz, Honghuang Lin, Michelle T. Long, Renate B. Schnabel, David D. McManus, Patrick T. Ellinor, Vasan S. Ramachandran, Thomas J. Wang, Robert E. Gerszten, Emelia J. Benjamin, Xiaoyan Yin, Michiel Rienstra
Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study)
published pages: 1493-1496, ISSN: 0002-9149, DOI: 10.1016/j.amjcard.2016.08.010
The American Journal of Cardiology 118/10 2019-06-06
2016 Meike Ramuschkat, Sebastian Appelbaum, Dorothee Atzler, Tanja Zeller, Christoph Bauer, Francisco M. Ojeda, Christoph R. Sinning, Boris Hoffmann, Karl J. Lackner, Rainer H. Böger, Philipp S. Wild, Thomas Münzel, Stefan Blankenberg, Edzard Schwedhelm, Renate B. Schnabel
ADMA, subclinical changes and atrial fibrillation in the general population
published pages: 640-646, ISSN: 0167-5273, DOI: 10.1016/j.ijcard.2015.05.102
International Journal of Cardiology 203 2019-06-06
2016 Aisha Gohar, Renate B. Schnabel, Maria Hughes, Tanja Zeller, Stefan Blankenberg, Gerard Pasterkamp, Hester den Ruijter
Underrepresentation of sex in reporting traditional and emerging biomarkers for primary prevention of cardiovascular disease: a systematic review
published pages: 99-107, ISSN: 2058-5225, DOI: 10.1093/ehjqcco/qcv028
European Heart Journal - Quality of Care and Clinical Outcomes 2/2 2019-06-06
2018 Jolanta M. Siller-Matula, Ladislav Pecen, Giuseppe Patti, Markus Lucerna, Paulus Kirchhof, Maciej Lesiak, Kurt Huber, Freek W.A. Verheugt, Irene M. Lang, Giulia Renda, Renate B. Schnabel, Rolf Wachter, Dipak Kotecha, Jean-Marc Sellal, Miklos Rohla, Fabrizio Ricci, Raffaele De Caterina
Heart failure subtypes and thromboembolic risk in patients with atrial fibrillation: The PREFER in AF - HF substudy
published pages: 141-147, ISSN: 0167-5273, DOI: 10.1016/j.ijcard.2018.04.093
International Journal of Cardiology 265 2019-06-06
2017 Renate B Schnabel, Ladislav Pecen, Francisco M Ojeda, Markus Lucerna, Nargiz Rzayeva, Stefan Blankenberg, Harald Darius, Dipak Kotecha, Raffaele De Caterina, Paulus Kirchhof
Gender differences in clinical presentation and 1-year outcomes in atrial fibrillation
published pages: 1024-1030, ISSN: 1355-6037, DOI: 10.1136/heartjnl-2016-310406
Heart 103/13 2019-06-06
2018 Carolina Roselli, Mark D. Chaffin, Lu-Chen Weng, Stefanie Aeschbacher, Gustav Ahlberg, Christine M. Albert, Peter Almgren, Alvaro Alonso, Christopher D. Anderson, Krishna G. Aragam, Dan E. Arking, John Barnard, Traci M. Bartz, Emelia J. Benjamin, Nathan A. Bihlmeyer, Joshua C. Bis, Heather L. Bloom, Eric Boerwinkle, Erwin B. Bottinger, Jennifer A. Brody, Hugh Calkins, Archie Campbell, Thomas P. Cappola, John Carlquist, Daniel I. Chasman, Lin Y. Chen, Yii-Der Ida Chen, Eue-Keun Choi, Seung Hoan Choi, Ingrid E. Christophersen, Mina K. Chung, John W. Cole, David Conen, James Cook, Harry J. Crijns, Michael J. Cutler, Scott M. Damrauer, Brian R. Daniels, Dawood Darbar, Graciela Delgado, Joshua C. Denny, Martin Dichgans, Marcus Dörr, Elton A. Dudink, Samuel C. Dudley, Nada Esa, Tonu Esko, Markku Eskola, Diane Fatkin, Stephan B. Felix, Ian Ford, Oscar H. Franco, Bastiaan Geelhoed, Raji P. Grewal, Vilmundur Gudnason, Xiuqing Guo, Namrata Gupta, Stefan Gustafsson, Rebecca Gutmann, Anders Hamsten, Tamara B. Harris, Caroline Hayward, Susan R. Heckbert, Jussi Hernesniemi, Lynne J. Hocking, Albert Hofman, Andrea R. V. R. Horimoto, Jie Huang, Paul L. Huang, Jennifer Huffman, Erik Ingelsson, Esra Gucuk Ipek, Kaoru Ito, Jordi Jimenez-Conde, Renee Johnson, J. Wouter Jukema, Stefan Kääb, Mika Kähönen, Yoichiro Kamatani, John P. Kane, Adnan Kastrati, Sekar Kathiresan, Petra Katschnig-Winter, Maryam Kavousi, Thorsten Kessler, Bas L. Kietselaer, Paulus Kirchhof, Marcus E. Kleber, Stacey Knight, Jose E. Krieger, Michiaki Kubo, Lenore J. Launer, Jari Laurikka, Terho Lehtimäki, Kirsten Leineweber, Rozenn N. Lemaitre, Man Li, Hong Euy Lim, Henry J. Lin, Honghuang Lin, Lars Lind, Cecilia M. Lindgren, Marja-Liisa Lokki, Barry London, Ruth J. F. Loos, Siew-Kee Low, Yingchang Lu, Leo-Pekka Lyytikäinen, Peter W. Macfarlane, Patrik K. Magnusson, Anubha Mahajan, Rainer Malik, Alfredo J. Mansur, Gregory M. Marcus, Lauren Margolin, Kenneth B. Margulies, Winfried März, David D. McManus, Olle Melander, Sanghamitra Mohanty, Jay A. Montgomery, Michael P. Morley, Andrew P. Morris, Martina Müller-Nurasyid, Andrea Natale, Saman Nazarian, Benjamin Neumann, Christopher Newton-Cheh, Maartje N. Niemeijer, Kjell Nikus, Peter Nilsson, Raymond Noordam, Heidi Oellers, Morten S. Olesen, Marju Orho-Melander, Sandosh Padmanabhan, Hui-Nam Pak, Guillaume Paré, Nancy L. Pedersen, Joanna Pera, Alexandre Pereira, David Porteous, Bruce M. Psaty, Sara L. Pulit, Clive R. Pullinger, Daniel J. Rader, Lena Refsgaard, Marta Ribasés, Paul M. Ridker, Michiel Rienstra, Lorenz Risch, Dan M. Roden, Jonathan Rosand, Michael A. Rosenberg, Natalia Rost, Jerome I. Rotter, Samir Saba, Roopinder K. Sandhu, Renate B. Schnabel, Katharina Schramm, Heribert Schunkert, Claudia Schurman, Stuart A. Scott, Ilkka Seppälä, Christian Shaffer, Svati Shah, Alaa A. Shalaby, Jaemin Shim, M. Benjamin Shoemaker, Joylene E. Siland, Juha Sinisalo, Moritz F. Sinner, Agnieszka Slowik, Albert V. Smith, Blair H. Smith, J. Gustav Smith, Jonathan D. Smith, Nicholas L. Smith, Elsayed Z. Soliman, Nona Sotoodehnia, Bruno H. Stricker, Albert Sun, Han Sun, Jesper H. Svendsen, Toshihiro Tanaka, Kahraman Tanriverdi, Kent D. Taylor, Maris Teder-Laving, Alexander Teumer, Sébastien Thériault, Stella Trompet, Nathan R. Tucker, Arnljot Tveit, Andre G. Uitterlinden, Pim Van Der Harst, Isabelle C. Van Gelder, David R. Van Wagoner, Niek Verweij, Efthymia Vlachopoulou, Uwe Völker, Biqi Wang, Peter E. Weeke, Bob Weijs, Raul Weiss, Stefan Weiss, Quinn S. Wells, Kerri L. Wiggins, Jorge A. Wong, Daniel Woo, Bradford B. Worrall, Pil-Sung Yang, Jie Yao, Zachary T. Yoneda, Tanja Zeller, Lingyao Zeng, Steven A. Lubitz, Kathryn L. Lunetta, Patrick T. Ellinor
Multi-ethnic genome-wide association study for atrial fibrillation
published pages: , ISSN: 1061-4036, DOI: 10.1038/s41588-018-0133-9
Nature Genetics 2019-06-06
2018 Tanja Zeller, Renate B Schnabel, Sebastian Appelbaum, Francisco Ojeda, Filip Berisha, Benedict Schulte-Steinberg, Burkhard-Ekkehart Brueckmann, Kari Kuulasmaa, Pekka Jousilahti, Stefan Blankenberg, Tarja Palosaari, Veikko Salomaa, Mahir Karakas
Low testosterone levels are predictive for incident atrial fibrillation and ischaemic stroke in men, but protective in women – results from the FINRISK study
published pages: 1133-1139, ISSN: 2047-4873, DOI: 10.1177/2047487318778346
European Journal of Preventive Cardiology 25/11 2019-06-06
2017 Renate B Schnabel, Ladislav Pecen, Daniel Engler, Markus Lucerna, Jean Marc Sellal, Francisco M Ojeda, Raffaele De Caterina, Paulus Kirchhof
Atrial fibrillation patterns are associated with arrhythmia progression and clinical outcomes
published pages: heartjnl-2017-31, ISSN: 1355-6037, DOI: 10.1136/heartjnl-2017-312569
Heart 2019-06-06
2018 Renate B. Schnabel, Emelia J. Benjamin
Sex and Stroke Risk in Atrial Fibrillation
published pages: 615-617, ISSN: 2405-500X, DOI: 10.1016/j.jacep.2018.03.002
JACC: Clinical Electrophysiology 4/5 2019-06-06
2017 Ben Freedman, John Camm, Hugh Calkins, Jeffrey S. Healey, MÃ¥rten Rosenqvist, Jiguang Wang, Christine M. Albert, Craig S. Anderson, Sotiris Antoniou, Emelia J. Benjamin, Giuseppe Boriani, Johannes Brachmann, Axel Brandes, Tze-Fan Chao, David Conen, Johan Engdahl, Laurent Fauchier, David A. Fitzmaurice, Leif Friberg, Bernard J. Gersh, David J. Gladstone, Taya V. Glotzer, Kylie Gwynne, Graeme J. Hankey, Joseph Harbison, Graham S. Hillis, Mellanie T. Hills, Hooman Kamel, Paulus Kirchhof, Peter R. Kowey, Derk Krieger, Vivian W. Y. Lee, Lars-Ã…ke Levin, Gregory Y. H. Lip, Trudie Lobban, Nicole Lowres, Georges H. Mairesse, Carlos Martinez, Lis Neubeck, Jessica Orchard, Jonathan P. Piccini, Katrina Poppe, Tatjana S. Potpara, Helmut Puererfellner, Michiel Rienstra, Roopinder K. Sandhu, Renate B. Schnabel, Chung-Wah Siu, Steven Steinhubl, Jesper H. Svendsen, Emma Svennberg, Sakis Themistoclakis, Robert G. Tieleman, Mintu P. Turakhia, Arnljot Tveit, Steven B. Uittenbogaart, Isabelle C. Van Gelder, Atul Verma, Rolf Wachter, Bryan P. Yan
Screening for Atrial Fibrillation
published pages: 1851-1867, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.116.026693
Circulation 135/19 2019-06-06
2016 Francisco M. Ojeda, Christian Müller, Daniela Börnigen, David-Alexandre Trégouët, Arne Schillert, Matthias Heinig, Tanja Zeller, Renate B. Schnabel
Comparison of Cox Model Methods in A Low-dimensional Setting with Few Events
published pages: 235-243, ISSN: 1672-0229, DOI: 10.1016/j.gpb.2016.03.006
Genomics, Proteomics & Bioinformatics 14/4 2019-06-06

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