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SYNDEGEN SIGNED

Synaptic dysfunction in Neurodegenerative Diseases

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SYNDEGEN project word cloud

Explore the words cloud of the SYNDEGEN project. It provides you a very rough idea of what is the project "SYNDEGEN" about.

gap    pathologically    societies    misfolding    pd    tau    train    dysfunctional    diseases    burden    hd    aging    beta    disorders    interdisciplinary    aggregation    spread    molecular    cell    roles    broad    biology    normal    strategies    proteins    huntingtin    precursor    dysfunction    students    alzheimer    questions    smes    syndegen    collaborative    edge    huntington    young    academic    site    representing    stem    purpose    talented    company    experts    ndds    degeneration    sufficiently    asked    aberrant    sites    mechanisms    cutting    neurodegenerative    whereby    therapies    ad    disease    training    cellular    university    synapses    alpha    imaging    partnership    treatment    technologies    synaptic    interactive    protein    scientists    amyloid    expertise    synapse    locations    innovative    multidisciplinary    isolated    physiological    parkinson    centres    neurons    genetically    linked    points    prone    synuclein    localized    begin    groups   

Project "SYNDEGEN" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website http://syndegen.eu
 Total cost 3˙129˙428 €
 EC max contribution 3˙129˙428 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 790˙977.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 788˙626.00
3    DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV DE (BONN) participant 498˙432.00
4    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 273˙287.00
5    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) participant 265˙226.00
6    UMECRINE AB SE (UMEA) participant 263˙659.00
7    UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS DE (GOETTINGEN) participant 249˙216.00
8    EXPLORA NOVA SARL FR (LA ROCHELLE) participant 0.00
9    H. LUNDBECK AS DK (VALBY) partner 0.00
10    NEUROPROOF GMBH DE (ROSTOCK) partner 0.00
11    SKANE LANS LANDSTING SE (KRISTIANSTAD) partner 0.00
12    SWEDISH PARKINSON FOUNDATION SE (Stockholm) partner 0.00
13    UMEA UNIVERSITET SE (UMEA) partner 0.00
14    UNIVERSITAET ULM DE (ULM) partner 0.00

Map

 Project objective

Neurodegenerative diseases (NDDs) of aging are a growing burden on societies. Although studies on the degeneration of neurons have been a main focus of research, increasing evidence points to synapses as the site where Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD) begin. There is growing evidence that synapses are sites of early and aberrant protein misfolding, aggregation and spread in NDDs. A key problem in research on NDDs has been that the normal physiological roles at synapses of the aggregation-prone proteins (β- amyloid/amyloid precursor protein, tau, α-synuclein and huntingtin), which are linked pathologically and genetically to these diseases, are not known. Using cutting-edge technologies and multidisciplinary approaches the SYNDEGEN consortium aims to bring together leading experts in cell biology, synapse biology and imaging, stem cell biology and NDDs in Europe to determine the molecular and cellular mechanisms whereby synapses become dysfunctional in AD, PD and HD for the purpose of developing novel therapies. The goal of the consortium is to train talented young scientists in interdisciplinary, innovative and collaborative research aimed at the development of novel molecular based treatment strategies for these major diseases of aging. A gap in the training of students in these important diseases is that disease expertise and novel methods to study synapses are localized in isolated groups in different locations in the EU. Similar questions are being asked about the mechanisms of synaptic dysfunction in AD, PD and HD, but no one university or company has sufficiently broad knowledge and technical expertise required to study and develop therapies for synaptic dysfunction in these disorders. This training programme will be implemented in 6 academic centres and 2 SMEs representing a comprehensive, highly interactive and multidisciplinary partnership.

 Publications

year authors and title journal last update
List of publications.
2018 Inês Caldeira Brás, Luísa V. Lopes, Tiago Fleming Outeiro
Sensing α-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration
published pages: 1675-1684, ISSN: 0885-3185, DOI: 10.1002/mds.27478
Movement Disorders 33/11 2019-07-09
2018 Inês Caldeira Brás, Sandra Tenreiro, Andreia M Silva, Tiago F Outeiro
Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast
published pages: , ISSN: 1567-1364, DOI: 10.1093/femsyr/foy108
FEMS Yeast Research 18/8 2019-07-09

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The information about "SYNDEGEN" are provided by the European Opendata Portal: CORDIS opendata.

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